A general and practical oxidation of alcohols to primary amides under metal-free conditions

Xiao Feng Wu, Muhammad Sharif, Jian Bo Feng, Helfried Neumann, Anahit Pews-Davtyan, Peter Langer, Matthias Beller

Research output: Contribution to journalArticlepeer-review

38 Scopus citations

Abstract

A general procedure for oxidation of both benzyl alcohols and alkyl alcohols to primary amides under catalyst free conditions has been developed. 34 examples of primary amides were produced from their corresponding alcohols in moderate to excellent yields. This is a practical procedure for primary amides synthesis; water and tert-butanol are the only by-products. A commercial drug, Piracetam, was prepared in one step with 73% yield as well.

Original languageEnglish
Pages (from-to)1956-1961
Number of pages6
JournalGreen Chemistry
Volume15
Issue number7
DOIs
StatePublished - Jul 2013
Externally publishedYes

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