A General and Highly Selective Cobalt-Catalyzed Hydrogenation of N-Heteroarenes under Mild Reaction Conditions

Rosa Adam, Jose R. Cabrero-Antonino, Anke Spannenberg, Kathrin Junge, Ralf Jackstell, Matthias Beller

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133 Scopus citations

Abstract

Herein, a general and efficient method for the homogeneous cobalt-catalyzed hydrogenation of N-heterocycles, under mild reaction conditions, is reported. Key to success is the use of the tetradentate ligand tris(2-(diphenylphosphino)phenyl)phosphine). This non-noble metal catalyst system allows the selective hydrogenation of heteroarenes in the presence of a broad range of other sensitive reducible groups.

Original languageEnglish
Pages (from-to)3216-3220
Number of pages5
JournalAngewandte Chemie International Edition in English
Volume56
Issue number12
DOIs
StatePublished - 13 Mar 2017
Externally publishedYes

Keywords

  • cobalt
  • homogeneous catalysis
  • hydrogenation
  • nitrogen heterocycles
  • phosphines

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