A general and efficient method for the formylation of aryl and heteroaryl bromides

Stefan Klaus, Helfried Neumann, Alexander Zapf, Dirk Strübing, Sandra Hübner, Juan Almena, Thomas Riermeier, Peter Groß, Martin Sarich, Wolf Rüdiger Krahnert, Kai Rossen, Matthias Beller

Research output: Contribution to journalArticlepeer-review

133 Scopus citations

Abstract

(Chemical Equation Presented) The key to the general and efficient palladium-catalyzed formylation of aryl and heteroaryl bromides is the use of the di-1-adamantyl-n-butylphosphane (cataC-Xium A) as ligand. Low pressure of the synthesis gas and appropriate choice of the base are also important for high yields (up to 99%) of a broad range of (hetero)aromatic aldehydes at unprecedented low catalyst concentrations (see scheme; TMEDA= N,N,N′,N′-tetramethylethylenediamine).

Original languageEnglish
Pages (from-to)154-158
Number of pages5
JournalAngewandte Chemie International Edition in English
Volume45
Issue number1
DOIs
StatePublished - 16 Dec 2005
Externally publishedYes

Keywords

  • Aldehydes
  • Aryl halides
  • Carbon monoxide
  • Formylation
  • Palladium

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