A General, Activator-Free Palladium-Catalyzed Synthesis of Arylacetic and Benzoic Acids from Formic Acid

Lin Wang, Helfried Neumann, Matthias Beller

Research output: Contribution to journalArticlepeer-review

29 Scopus citations

Abstract

A new catalyst for the carboxylative synthesis of arylacetic and benzoic acids using formic acid (HCOOH) as the CO surrogate was developed. In an improvement over previous work, CO is generated in situ without the need for any additional activators. Key to success was the use of a specific system consisting of palladium acetate and 1,2-bis((tert-butyl(2-pyridinyl)phosphinyl)methyl)benzene. The generality of this method is demonstrated by the synthesis of more than 30 carboxylic acids, including non-steroidal anti-inflammatory drugs (NSAIDs), under mild conditions in good yields.

Original languageEnglish
Pages (from-to)6910-6914
Number of pages5
JournalAngewandte Chemie International Edition in English
Volume57
Issue number23
DOIs
StatePublished - 4 Jun 2018
Externally publishedYes

Keywords

  • bisphosphine ligands
  • carboxylation
  • carboxylic acids
  • formic acid
  • palladium catalysis

Fingerprint

Dive into the research topics of 'A General, Activator-Free Palladium-Catalyzed Synthesis of Arylacetic and Benzoic Acids from Formic Acid'. Together they form a unique fingerprint.

Cite this