@article{deadeaba159843088e845daad32dd869,
title = "A crystallin fold in the interleukin-4-inducing principle of schistosoma mansoni eggs (IPSE/α-1) mediates IgE binding for antigen-independent basophil activation",
abstract = "Background: The interleukin-4-inducing principle from Schistosoma mansoni eggs (IPSE/α-1) triggers basophils to release interleukin-4 and interleukin-13 in an IgE-dependent but antigen-independent way. Results: Structural analysis identified IPSE/α-1 as a new member of the βγ-crystallin superfamily with a unique IgE-binding loop. Conclusion: IPSE/α-1 activates basophils via IgE-binding crystallin folds. Significance: Schistosomes use unique mechanisms to manipulate the host's immune response.",
author = "Meyer, \{N. Helge\} and Hubert Mayerhofer and Konstantinos Tripsianes and Silke Blindow and Daniela Barths and Astrid Mewes and Thomas Weimar and Thies K{\"o}hli and Steffen Bade and Tobias Madl and Andreas Frey and Helmut Haas and Jochen Mueller-Dieckmann and Michael Sattler and Gabriele Schramm",
note = "Publisher Copyright: {\textcopyright} 2015 by The American Society for Biochemistry and Molecular Biology, Inc.",
year = "2015",
month = sep,
day = "4",
doi = "10.1074/jbc.M115.675066",
language = "English",
volume = "290",
pages = "22111--22126",
journal = "Journal of Biological Chemistry",
issn = "0021-9258",
publisher = "American Society for Biochemistry and Molecular Biology Inc.",
number = "36",
}