A convenient synthesis of benzonitriles via electrophilic cyanation with N-cyanobenzimidazole

Pazhamalai Anbarasan, Helfried Neumann, Matthias Beller

Research output: Contribution to journalArticlepeer-review

91 Scopus citations

Abstract

(Chemical Equation Presented) Couplings: N-Cyanobenzimidazole has been used in the synthesis of aryl- and heteroarylnitriles from the corresponding Grignard reagents (see scheme). This electrophilic cyanation is further extended to the synthesis of 2-cyano1,1'-biaryls through a domino Grignard-coupling/ cyanation strategy.

Original languageEnglish
Pages (from-to)4725-4728
Number of pages4
JournalChemistry - A European Journal
Volume16
Issue number16
DOIs
StatePublished - 26 Apr 2010
Externally publishedYes

Keywords

  • Arenes
  • Benzimidazole
  • Cyanides
  • Electrophilic cyanation
  • Grignard reaction

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