A convenient rhodium-catalyzed intermolecular hydroamination procedure for terminal alkynes

C. G. Hartung, A. Tillack, H. Trauthwein, M. Beller

Research output: Contribution to journalArticlepeer-review

126 Scopus citations

Abstract

The first rhodium-catalyzed intermolecular hydroamination of alkynes is presented. Terminal alkynes react efficiently with anilines in the presence of cationic rhodium(I) catalysts under very mild reaction conditions (e.g., base and acid free at room temperature) to yield up to 99% of the corresponding imines. An easy one-pot protocol for the synthesis of secondary amines was developed by combining this alkyne amination reaction with in situ addition of organolithium reagents.

Original languageEnglish
Pages (from-to)6339-6343
Number of pages5
JournalJournal of Organic Chemistry
Volume66
Issue number19
DOIs
StatePublished - 21 Sep 2001
Externally publishedYes

Fingerprint

Dive into the research topics of 'A convenient rhodium-catalyzed intermolecular hydroamination procedure for terminal alkynes'. Together they form a unique fingerprint.

Cite this