A convenient procedure for the palladium-catalyzed cyanation of aryl halides

Mark Sundermeier, Alexander Zapf, Matthias Beller

Research output: Contribution to journalArticlepeer-review

266 Scopus citations

Abstract

A useful source of cyanide for the palladium-catalyzed cyanation of aryl halides is acetone cyanohydrin (see scheme; dpppe = 1,5-bis(diphenylphosphanyl) pentane, tmeda = N,N,N′,N′-tetramethylethylenediamine). The key to the success of the reaction is the slow dosage of the cyanation reagent to the reaction mixture to prevent the deactivation of the palladium catalyst caused by excess cyanide ions in solution.

Original languageEnglish
Pages (from-to)1661-1664
Number of pages4
JournalAngewandte Chemie International Edition in English
Volume42
Issue number14
DOIs
StatePublished - 11 Apr 2003
Externally publishedYes

Keywords

  • Acetone cyanohydrin
  • Aryl halides
  • Benzonitriles cyanation
  • Palladium

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