A convenient and practical synthesis of anisoles and deuterated anisoles by palladium-catalyzed coupling reactions of aryl bromides and chlorides

Saravanan Gowrisankar, Helfried Neumann, Matthias Beller

Research output: Contribution to journalArticlepeer-review

59 Scopus citations

Abstract

Synthesis of anisole: Aryl and heteroaryl halides undergo selective C-O cross-coupling reactions with methanol in the presence of a Pd(OAc) 2/L3 catalyst system. The corresponding ethers were obtained under mild conditions in good yields. The catalytic methodology was also used for the synthesis of labeled deuterated anisoles in good yields (see scheme).

Original languageEnglish
Pages (from-to)2498-2502
Number of pages5
JournalChemistry - A European Journal
Volume18
Issue number9
DOIs
StatePublished - 27 Feb 2012
Externally publishedYes

Keywords

  • anisole
  • cross-coupling
  • deuterium
  • palladium
  • synthetic methods

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