A convenient and general method for the synthesis of indole-2,3- dicarboxylates and 2-arylindole-3-carboxylates

Iliyas Ali Sayyed, Karolin Alex, Annegret Tillack, Nicolle Schwarz, Dirk Michalik, Matthias Beller

Research output: Contribution to journalArticlepeer-review

42 Scopus citations

Abstract

A transition-metal-free, simple and efficient one-pot method for the synthesis of indole-2,3-dicarboxylates and 2-aryl-indole-3-carboxylates is described. The corresponding products are obtained by a domino hydroamination/Fischer indole cyclization in good-to-excellent yields from easily available 1-alkyl-1-phenylhydrazines and acetylene carboxylates.

Original languageEnglish
Pages (from-to)4525-4528
Number of pages4
JournalEuropean Journal of Organic Chemistry
Issue number27
DOIs
StatePublished - 2007
Externally publishedYes

Keywords

  • Alkynes
  • Hydroamination
  • Indoles

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