TY - GEN
T1 - A computational white matter atlas for aging with surface-based representation of fasciculi
AU - Zhang, Hui
AU - Yushkevich, Paul A.
AU - Rueckert, Daniel
AU - Gee, James C.
PY - 2010
Y1 - 2010
N2 - Voxel-based analysis, either whole-brain or tract-specific, is a widely used approach for localizing white matter (WM) differences across populations using diffusion tensor imaging (DTI). A prerequisite to this approach is to spatially normalize all the subjects to a common template. The accuracy of spatial normalization can be improved by using a population-specific template that is, morphologically, most similar to the subjects in the population of interest. Here, we report the development of a population-specific DTI template for the elderly using the publicly available IXI brain database. The template captures the average shape and diffusion properties of the aging population and contains segmentations of major WM fasciculi parcellated via fiber tractography. Furthermore, the segmentations are modeled using surface-based representation to support the tract-specific analysis recently proposed by Yushkevich et al. The utility of the template is demonstrated in an examination of WM changes in Amyotrophic Lateral Sclerosis.
AB - Voxel-based analysis, either whole-brain or tract-specific, is a widely used approach for localizing white matter (WM) differences across populations using diffusion tensor imaging (DTI). A prerequisite to this approach is to spatially normalize all the subjects to a common template. The accuracy of spatial normalization can be improved by using a population-specific template that is, morphologically, most similar to the subjects in the population of interest. Here, we report the development of a population-specific DTI template for the elderly using the publicly available IXI brain database. The template captures the average shape and diffusion properties of the aging population and contains segmentations of major WM fasciculi parcellated via fiber tractography. Furthermore, the segmentations are modeled using surface-based representation to support the tract-specific analysis recently proposed by Yushkevich et al. The utility of the template is demonstrated in an examination of WM changes in Amyotrophic Lateral Sclerosis.
UR - http://www.scopus.com/inward/record.url?scp=77955330120&partnerID=8YFLogxK
U2 - 10.1007/978-3-642-14366-3_8
DO - 10.1007/978-3-642-14366-3_8
M3 - Conference contribution
AN - SCOPUS:77955330120
SN - 3642143652
SN - 9783642143656
T3 - Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
SP - 83
EP - 90
BT - Biomedical Image Registration - 4th International Workshop, WBIR 2010, Proceedings
T2 - 4th International Workshop on Biomedical Image Registration, WBIR 2010
Y2 - 11 July 2010 through 13 July 2010
ER -