TY - JOUR
T1 - A comprehensive and comparative phenotypic analysis of the collaborative founder strains identifies new and known phenotypes
AU - Mouse Phenome Database Team
AU - Kollmus, Heike
AU - Fuchs, Helmut
AU - Lengger, Christoph
AU - Haselimashhadi, Hamed
AU - Bogue, Molly A.
AU - Östereicher, Manuela A.
AU - Horsch, Marion
AU - Adler, Thure
AU - Aguilar-Pimentel, Juan Antonio
AU - Amarie, Oana Veronica
AU - Becker, Lore
AU - Beckers, Johannes
AU - Calzada-Wack, Julia
AU - Garrett, Lillian
AU - Hans, Wolfgang
AU - Hölter, Sabine M.
AU - Klein-Rodewald, Tanja
AU - Maier, Holger
AU - Mayer-Kuckuk, Philipp
AU - Miller, Gregor
AU - Moreth, Kristin
AU - Neff, Frauke
AU - Rathkolb, Birgit
AU - Rácz, Ildikó
AU - Rozman, Jan
AU - Spielmann, Nadine
AU - Treise, Irina
AU - Busch, Dirk
AU - Graw, Jochen
AU - Klopstock, Thomas
AU - Wolf, Eckhard
AU - Wurst, Wolfgang
AU - Yildirim, Ali Önder
AU - Mason, Jeremy
AU - Torres, Arturo
AU - Balling, Rudi
AU - Mehaan, Terry
AU - Gailus-Durner, Valerie
AU - Schughart, Klaus
AU - Hrabě de Angelis, Martin
N1 - Publisher Copyright:
© 2020, The Author(s).
PY - 2020/2/1
Y1 - 2020/2/1
N2 - The collaborative cross (CC) is a large panel of mouse-inbred lines derived from eight founder strains (NOD/ShiLtJ, NZO/HILtJ, A/J, C57BL/6J, 129S1/SvImJ, CAST/EiJ, PWK/PhJ, and WSB/EiJ). Here, we performed a comprehensive and comparative phenotyping screening to identify phenotypic differences and similarities between the eight founder strains. In total, more than 300 parameters including allergy, behavior, cardiovascular, clinical blood chemistry, dysmorphology, bone and cartilage, energy metabolism, eye and vision, immunology, lung function, neurology, nociception, and pathology were analyzed; in most traits from sixteen females and sixteen males. We identified over 270 parameters that were significantly different between strains. This study highlights the value of the founder and CC strains for phenotype-genotype associations of many genetic traits that are highly relevant to human diseases. All data described here are publicly available from the mouse phenome database for analyses and downloads.
AB - The collaborative cross (CC) is a large panel of mouse-inbred lines derived from eight founder strains (NOD/ShiLtJ, NZO/HILtJ, A/J, C57BL/6J, 129S1/SvImJ, CAST/EiJ, PWK/PhJ, and WSB/EiJ). Here, we performed a comprehensive and comparative phenotyping screening to identify phenotypic differences and similarities between the eight founder strains. In total, more than 300 parameters including allergy, behavior, cardiovascular, clinical blood chemistry, dysmorphology, bone and cartilage, energy metabolism, eye and vision, immunology, lung function, neurology, nociception, and pathology were analyzed; in most traits from sixteen females and sixteen males. We identified over 270 parameters that were significantly different between strains. This study highlights the value of the founder and CC strains for phenotype-genotype associations of many genetic traits that are highly relevant to human diseases. All data described here are publicly available from the mouse phenome database for analyses and downloads.
UR - http://www.scopus.com/inward/record.url?scp=85079503404&partnerID=8YFLogxK
U2 - 10.1007/s00335-020-09827-3
DO - 10.1007/s00335-020-09827-3
M3 - Article
C2 - 32060626
AN - SCOPUS:85079503404
SN - 0938-8990
VL - 31
SP - 30
EP - 48
JO - Mammalian Genome
JF - Mammalian Genome
IS - 1-2
ER -