A comparison between nailfold capillaroscopy patterns in adulthood in juvenile and adult-onset systemic sclerosis: A EUSTAR exploratory study

on behalf of the EUSTAR co-authors

doi:10.1016/j.mvr.2015.07.007

A comparison between nailfold capillaroscopy patterns in adulthood in juvenile and adult-onset systemic sclerosis: A EUSTAR exploratory study

on behalf of the EUSTAR co-authors

Department of Dermatology and Allergology

UOC Reumatologia e Immunologia Clinica
ASST Spedali Civili di Brescia
University of Milan
Istituto Gaetano Pini
Medical Statistics and Biometry
Ghent University Hospital
University of Genova
Hamburg Center for Pediatric and Adolescent Rheumatology
Hospital Dr. Peset
Univ-Paris Diderot Sorbonne Paris-Cité
Immunology and Molecular Biology Laboratory
“Grigore T. Popa” University of Medicine and Pharmacy Iasi
Psicobiol. Univ. Fed. de Sao Paolo
Division of Rheumatology
Charles University in Prague
Ion Cantacuzino Clinical Hospital
Vilnius University
University of Foggia
Fondazione IRCCS Policlinico San Matteo
Unità di Reumatologia AOUI Verona
Hospital Universitario 12 de Octubre
Universidad de Buenos Aires
Azienda Ospedaliera Universitaria Federico II
University of Pecs Medical School
Hospital Universitàrio de Coimbra
Hospital Universitario Madrid Norte Sanchinarro
Federal University of Paraná
Gentofte Hospital
University Hospital of Catania
University Hospital Zurich
CHRU Roger Salengro
Clinical Emergency Hospital St Pantelimon
Hôpital Saint-Louis
Justus-Liebig-Universität Gießen
Università di Ancona
Rikshospitalet-Radiumhospitalet HF
Clinica Corominas
Central Military Emergency University Hospital
University of Florence
Universitätsklinikum Carl Gustav Carus Dresden
Technical University of Munich
Marien Hospital Stuttgart
Universitätsklinikum Tübingen
Lunds University Hospital
University of Otago
University of Bari
University of Silesia
Endokrinologikum Frankfurt
Peking Union Medical College Hospital
Tel Aviv Sourasky Medical Center
Wroclaw Medical University
Université Paris Descartes
Rheumatology Granollers General Hospital
East-Tallin Central Hospital
Kaunas University of Medicine Hospital
Universita La Sapienza
San Gerardo Hospital
IRCCS for Cancer Research
University Medical Centre Ljubljana
University of Bonn and University Hospital Bonn
University of Waikato
Institute for Prevention
University of Debrecen
University Hospital Basel
University of Cagliari
Unit of Internal Medicine

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Objective: Qualitative capillaroscopy patterns in juvenile- and adult-onset systemic sclerosis (SSc) were studied in adulthood using data from the EULAR Scleroderma Trials and Research (EUSTAR) database. Methods: Data collected between June 2004 and April 2013 were examined with focus on capillaroscopy. In this retrospective exploratory study, series of patients with juvenile-onset SSc were matched with series of adult-onset SSc having the same gender and autoantibody profile. Results: 30 of 123 patients with juvenile-onset and 2108 of 7133 with adult-onset SSc had data on capillaroscopy. Juvenile-onset SSc showed scleroderma pattern more frequently than adult-onset SSc (93.3% and 88%). The OR was 2.44 and 95% CI 0.57-10.41. An active scleroderma pattern was present in 58% of juvenile- and 61% of adult-onset SSc. The OR was 0.91 and 95% CI 0.28-2.93. The late scleroderma pattern was present in 61% of juvenile- and 55.5% of adult-onset SSc. The OR was 1.06 and 95% CI 0.34-3.56. Conclusion: This is the first exploratory study on the comparison of capillaroscopy between juvenile- and adult-onset SSc in adulthood. Juvenile-onset SSc had an increase prevalence of scleroderma pattern, but a similar distribution of the three patterns was suggested. Further studies are needed to define this issue.

Original language	English
Pages (from-to)	19-24
Number of pages	6
Journal	Microvascular Research
Volume	102
DOIs	https://doi.org/10.1016/j.mvr.2015.07.007
State	Published - Nov 2015

Keywords

Capillaroscopy
EUSTAR
Juvenile systemic sclerosis
Microcirculation
Nailfold capillaroscopy
Systemic sclerosis
Videocapillaroscopy

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10.1016/j.mvr.2015.07.007

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@article{d13bd40af5044f9db88b636fe99bb9bd,

title = "A comparison between nailfold capillaroscopy patterns in adulthood in juvenile and adult-onset systemic sclerosis: A EUSTAR exploratory study",

abstract = "Objective: Qualitative capillaroscopy patterns in juvenile- and adult-onset systemic sclerosis (SSc) were studied in adulthood using data from the EULAR Scleroderma Trials and Research (EUSTAR) database. Methods: Data collected between June 2004 and April 2013 were examined with focus on capillaroscopy. In this retrospective exploratory study, series of patients with juvenile-onset SSc were matched with series of adult-onset SSc having the same gender and autoantibody profile. Results: 30 of 123 patients with juvenile-onset and 2108 of 7133 with adult-onset SSc had data on capillaroscopy. Juvenile-onset SSc showed scleroderma pattern more frequently than adult-onset SSc (93.3\% and 88\%). The OR was 2.44 and 95\% CI 0.57-10.41. An active scleroderma pattern was present in 58\% of juvenile- and 61\% of adult-onset SSc. The OR was 0.91 and 95\% CI 0.28-2.93. The late scleroderma pattern was present in 61\% of juvenile- and 55.5\% of adult-onset SSc. The OR was 1.06 and 95\% CI 0.34-3.56. Conclusion: This is the first exploratory study on the comparison of capillaroscopy between juvenile- and adult-onset SSc in adulthood. Juvenile-onset SSc had an increase prevalence of scleroderma pattern, but a similar distribution of the three patterns was suggested. Further studies are needed to define this issue.",

keywords = "Capillaroscopy, EUSTAR, Juvenile systemic sclerosis, Microcirculation, Nailfold capillaroscopy, Systemic sclerosis, Videocapillaroscopy",

author = "\{on behalf of the EUSTAR co-authors\} and Francesca Ingegnoli and Patrizia Boracchi and Roberta Gualtierotti and Vanessa Smith and Maurizio Cutolo and Ivan Foeldvari and Paolo Air{\`o} and Alegre-Sancho, \{Juan Jose\} and Yannick Allanore and Ananieva, \{Lidia P.\} and Codrina Ancuta and Andrade, \{Luis Eduardo\} and Martin Aringer and Radim Becvar and Mihai Bojinca and Irena Butrimiene and Cantatore, \{Francesco Paolo\} and Roberto Caporali and Paola Caramaschi and Carreira, \{Patricia E.\} and Rodica Chirieac and Ada Corrado and Vanesa Cosentino and Giovanna Cuomo and Laszlo Czirjak and \{Da Silva\}, \{Jos{\'e} Antonio Pereira\} and \{de la Pe{\~n}a Lefebvre\}, \{Paloma Garc{\'i}a\} and \{De Keyser\}, Filip and \{de Souza M{\"u}ller\}, Carolina and Kirsten Damgaard and Nemanja Damjanov and Denisov, \{Lev N.\} and Oliver Distler and Alan Doube and Alina Dumitrascu and Merete Engelhart and Exposito, \{Marta Valero\} and Kilian Eyerich and Dominique Farge-Bancel and Azevedo, \{Valder{\'i}lio Feij{\'o}\} and Rosario Foti and Marc Frerix and Armando Gabrielli and Torhild Garen and Paola Gottschalk and Laura Groseanu and Serena Guiducci and Claudia G{\"u}nther and Eric Hachulla and R{\"u}diger Hein",

note = "Publisher Copyright: {\textcopyright} 2015 Elsevier Inc.",

year = "2015",

month = nov,

doi = "10.1016/j.mvr.2015.07.007",

language = "English",

volume = "102",

pages = "19--24",

journal = "Microvascular Research",

issn = "0026-2862",

publisher = "Academic Press Inc.",

}

TY - JOUR

T1 - A comparison between nailfold capillaroscopy patterns in adulthood in juvenile and adult-onset systemic sclerosis

T2 - A EUSTAR exploratory study

AU - on behalf of the EUSTAR co-authors

AU - Ingegnoli, Francesca

AU - Boracchi, Patrizia

AU - Gualtierotti, Roberta

AU - Smith, Vanessa

AU - Cutolo, Maurizio

AU - Foeldvari, Ivan

AU - Airò, Paolo

AU - Alegre-Sancho, Juan Jose

AU - Allanore, Yannick

AU - Ananieva, Lidia P.

AU - Ancuta, Codrina

AU - Andrade, Luis Eduardo

AU - Aringer, Martin

AU - Becvar, Radim

AU - Bojinca, Mihai

AU - Butrimiene, Irena

AU - Cantatore, Francesco Paolo

AU - Caporali, Roberto

AU - Caramaschi, Paola

AU - Carreira, Patricia E.

AU - Chirieac, Rodica

AU - Corrado, Ada

AU - Cosentino, Vanesa

AU - Cuomo, Giovanna

AU - Czirjak, Laszlo

AU - Da Silva, José Antonio Pereira

AU - de la Peña Lefebvre, Paloma García

AU - De Keyser, Filip

AU - de Souza Müller, Carolina

AU - Damgaard, Kirsten

AU - Damjanov, Nemanja

AU - Denisov, Lev N.

AU - Distler, Oliver

AU - Doube, Alan

AU - Dumitrascu, Alina

AU - Engelhart, Merete

AU - Exposito, Marta Valero

AU - Eyerich, Kilian

AU - Farge-Bancel, Dominique

AU - Azevedo, Valderílio Feijó

AU - Foti, Rosario

AU - Frerix, Marc

AU - Gabrielli, Armando

AU - Garen, Torhild

AU - Gottschalk, Paola

AU - Groseanu, Laura

AU - Guiducci, Serena

AU - Günther, Claudia

AU - Hachulla, Eric

AU - Hein, Rüdiger

PY - 2015/11

Y1 - 2015/11

N2 - Objective: Qualitative capillaroscopy patterns in juvenile- and adult-onset systemic sclerosis (SSc) were studied in adulthood using data from the EULAR Scleroderma Trials and Research (EUSTAR) database. Methods: Data collected between June 2004 and April 2013 were examined with focus on capillaroscopy. In this retrospective exploratory study, series of patients with juvenile-onset SSc were matched with series of adult-onset SSc having the same gender and autoantibody profile. Results: 30 of 123 patients with juvenile-onset and 2108 of 7133 with adult-onset SSc had data on capillaroscopy. Juvenile-onset SSc showed scleroderma pattern more frequently than adult-onset SSc (93.3% and 88%). The OR was 2.44 and 95% CI 0.57-10.41. An active scleroderma pattern was present in 58% of juvenile- and 61% of adult-onset SSc. The OR was 0.91 and 95% CI 0.28-2.93. The late scleroderma pattern was present in 61% of juvenile- and 55.5% of adult-onset SSc. The OR was 1.06 and 95% CI 0.34-3.56. Conclusion: This is the first exploratory study on the comparison of capillaroscopy between juvenile- and adult-onset SSc in adulthood. Juvenile-onset SSc had an increase prevalence of scleroderma pattern, but a similar distribution of the three patterns was suggested. Further studies are needed to define this issue.

AB - Objective: Qualitative capillaroscopy patterns in juvenile- and adult-onset systemic sclerosis (SSc) were studied in adulthood using data from the EULAR Scleroderma Trials and Research (EUSTAR) database. Methods: Data collected between June 2004 and April 2013 were examined with focus on capillaroscopy. In this retrospective exploratory study, series of patients with juvenile-onset SSc were matched with series of adult-onset SSc having the same gender and autoantibody profile. Results: 30 of 123 patients with juvenile-onset and 2108 of 7133 with adult-onset SSc had data on capillaroscopy. Juvenile-onset SSc showed scleroderma pattern more frequently than adult-onset SSc (93.3% and 88%). The OR was 2.44 and 95% CI 0.57-10.41. An active scleroderma pattern was present in 58% of juvenile- and 61% of adult-onset SSc. The OR was 0.91 and 95% CI 0.28-2.93. The late scleroderma pattern was present in 61% of juvenile- and 55.5% of adult-onset SSc. The OR was 1.06 and 95% CI 0.34-3.56. Conclusion: This is the first exploratory study on the comparison of capillaroscopy between juvenile- and adult-onset SSc in adulthood. Juvenile-onset SSc had an increase prevalence of scleroderma pattern, but a similar distribution of the three patterns was suggested. Further studies are needed to define this issue.

KW - Capillaroscopy

KW - EUSTAR

KW - Juvenile systemic sclerosis

KW - Microcirculation

KW - Nailfold capillaroscopy

KW - Systemic sclerosis

KW - Videocapillaroscopy

UR - https://www.scopus.com/pages/publications/84943651729

U2 - 10.1016/j.mvr.2015.07.007

DO - 10.1016/j.mvr.2015.07.007

M3 - Article

C2 - 26254260

AN - SCOPUS:84943651729

SN - 0026-2862

VL - 102

SP - 19

EP - 24

JO - Microvascular Research

JF - Microvascular Research

ER -

A comparison between nailfold capillaroscopy patterns in adulthood in juvenile and adult-onset systemic sclerosis: A EUSTAR exploratory study

Abstract

Keywords

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