A Cobalt Nanocatalyst for the Hydrogenation and Oxidative Dehydrogenation of N-heterocycles

Yue Hu, Xinmin Li, Mingyang Liu, Stephan Bartling, Henrik Lund, Jabor Rabeah, Paul J. Dyson, Matthias Beller, Rajenahally V. Jagadeesh

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Catalytic hydrogenation and oxidative dehydrogenation of N-heterocycles to produce tetrahydroquinoline and quinoline derivatives are important reactions of particular importance in the agrochemical and pharmaceutical industries. Herein, we report earth-abundant cobalt nanoparticles supported on hydroxyapatite (HAP) as an inexpensive and efficient catalyst for the hydrogenation and reverse oxidative dehydrogenation of N-heterocycles. The optimal nanocatalyst exhibits excellent activity in both reactions for a wide range of substrates including (iso)quinolines, acridine, benzo[h]quinoline, quinoxaline and indole. Reactions proceed under relatively mild conditions without requiring any additives.

Original languageEnglish
Article numbere202301027
Issue number1
StatePublished - 8 Jan 2024
Externally publishedYes


  • Co nanocatalyst
  • Hydrogenation
  • N-heterocycles
  • Oxidative dehydrogenation
  • Revisable reactions


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