A bioreducible linear poly(β-amino ester) for siRNA delivery

Kristen L. Kozielski; Stephany Y. Tzeng; Jordan J. Green

doi:10.1039/c3cc40718g

A bioreducible linear poly(β-amino ester) for siRNA delivery

Kristen L. Kozielski, Stephany Y. Tzeng, Jordan J. Green

Johns Hopkins School of Medicine

Research output: Contribution to journal › Article › peer-review

69 Scopus citations

Abstract

Described here is the synthesis and characterization of a novel, bioreducible linear poly(β-amino ester) designed to condense siRNA into nanoparticles and efficiently release it upon entering the cytoplasm. Delivery of siRNA using this polymer achieved near-complete knockdown of a fluorescent marker gene in primary human glioblastoma cells with no cytotoxicity.

Original language	English
Pages (from-to)	5319-5321
Number of pages	3
Journal	Chemical Communications
Volume	49
Issue number	46
DOIs	https://doi.org/10.1039/c3cc40718g
State	Published - 14 May 2013
Externally published	Yes

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10.1039/c3cc40718g

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title = "A bioreducible linear poly(β-amino ester) for siRNA delivery",

abstract = "Described here is the synthesis and characterization of a novel, bioreducible linear poly(β-amino ester) designed to condense siRNA into nanoparticles and efficiently release it upon entering the cytoplasm. Delivery of siRNA using this polymer achieved near-complete knockdown of a fluorescent marker gene in primary human glioblastoma cells with no cytotoxicity.",

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AU - Green, Jordan J.

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AB - Described here is the synthesis and characterization of a novel, bioreducible linear poly(β-amino ester) designed to condense siRNA into nanoparticles and efficiently release it upon entering the cytoplasm. Delivery of siRNA using this polymer achieved near-complete knockdown of a fluorescent marker gene in primary human glioblastoma cells with no cytotoxicity.

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A bioreducible linear poly(β-amino ester) for siRNA delivery

Abstract

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