A base-catalyzed domino-isomerization-hydroamination reaction - A new synthetic route to amphetamines

Christian G. Hartung, Claudia Breindl, Annegret Tillack, Matthias Beller

Research output: Contribution to journalArticlepeer-review

73 Scopus citations

Abstract

An efficient synthesis of pharmaceutically interesting amphetamines by a base-catalyzed domino-isomerization- hydroamination reaction is presented. Starting from allylbenzene and various primary or secondary amines, the basic structural pattern of amphetamines is synthesized directly in yields of up to 91% in the presence of catalytic amounts of n-butyllithium. (C) 2000 Elsevier Science Ltd.

Original languageEnglish
Pages (from-to)5157-5162
Number of pages6
JournalTetrahedron
Volume56
Issue number29
DOIs
StatePublished - 14 Jul 2000
Externally publishedYes

Keywords

  • Amphetamines
  • Base- catalysis
  • Domino-isomerization-amination reaction
  • Hydroamination

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