7α-Acetylugandensolide and antimicrobial properties of Warburgia ugandensis extracts and isolates against sweet potato pathogens

Sylvia A. Opiyo; Lawrence O.A. Manguro; Philip Okinda-Owuor; Elijah M. Ateka; Peter Lemmen

doi:10.1016/j.phytol.2011.02.007

7α-Acetylugandensolide and antimicrobial properties of Warburgia ugandensis extracts and isolates against sweet potato pathogens

Sylvia A. Opiyo, Lawrence O.A. Manguro, Philip Okinda-Owuor, Elijah M. Ateka, Peter Lemmen

Natural Sciences

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

7α-Acetylugandensolide together with thirteen known drimane-type sesquiterpenes have been isolated from Warbugia ugandensis bark extracts. Their structures were established by spectroscopic and physical methods as well as comparison with data available in the literature. The in vitro antimicrobial activities of the extracts and isolates were investigated against fungi and bacteria which infect sweet potato. Ethyl acetate extract exhibited the highest (P ≤ 0.05) antifungal and antibacterial activities compared to n-hexane and methanol extracts. Rhizopus stolonifer was more susceptible to ethyl acetate extract (inhibition zone = 24.5 mm) than Blitox which was used as a positive control. The minimum inhibitory concentration (MIC) for the isolates ranged between 12.5 and 200 μg/ml with the lowest MIC value of 12.5 μg/ml being observed with polygodial against Fusarium solani; warburganal against Aspergillus niger and F. solani; and mukaadial against A. niger.

Original language	English
Pages (from-to)	161-165
Number of pages	5
Journal	Phytochemistry Letters
Volume	4
Issue number	2
DOIs	https://doi.org/10.1016/j.phytol.2011.02.007
State	Published - 15 Jun 2011

Keywords

Antibacterial
Antifungal
Canellaceae
Drimane sesquiterpenes
Warburgia ugandensis

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10.1016/j.phytol.2011.02.007

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title = "7α-Acetylugandensolide and antimicrobial properties of Warburgia ugandensis extracts and isolates against sweet potato pathogens",

abstract = "7α-Acetylugandensolide together with thirteen known drimane-type sesquiterpenes have been isolated from Warbugia ugandensis bark extracts. Their structures were established by spectroscopic and physical methods as well as comparison with data available in the literature. The in vitro antimicrobial activities of the extracts and isolates were investigated against fungi and bacteria which infect sweet potato. Ethyl acetate extract exhibited the highest (P ≤ 0.05) antifungal and antibacterial activities compared to n-hexane and methanol extracts. Rhizopus stolonifer was more susceptible to ethyl acetate extract (inhibition zone = 24.5 mm) than Blitox which was used as a positive control. The minimum inhibitory concentration (MIC) for the isolates ranged between 12.5 and 200 μg/ml with the lowest MIC value of 12.5 μg/ml being observed with polygodial against Fusarium solani; warburganal against Aspergillus niger and F. solani; and mukaadial against A. niger.",

keywords = "Antibacterial, Antifungal, Canellaceae, Drimane sesquiterpenes, Warburgia ugandensis",

author = "Opiyo, {Sylvia A.} and Manguro, {Lawrence O.A.} and Philip Okinda-Owuor and Ateka, {Elijah M.} and Peter Lemmen",

note = "Funding Information: The authors are thankful to Kenya Medical Research Institute (KEMRI), Kisumu, Kenya for the use of their laboratory to perform the biological activity tests and Biosciences Eastern and Central Africa Network (BecANet) for financial support. Mr. Mutiso of Botany Department, Nairobi University is highly thanked for identification of the plant. ",

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AU - Manguro, Lawrence O.A.

AU - Okinda-Owuor, Philip

AU - Ateka, Elijah M.

AU - Lemmen, Peter

N1 - Funding Information: The authors are thankful to Kenya Medical Research Institute (KEMRI), Kisumu, Kenya for the use of their laboratory to perform the biological activity tests and Biosciences Eastern and Central Africa Network (BecANet) for financial support. Mr. Mutiso of Botany Department, Nairobi University is highly thanked for identification of the plant.

PY - 2011/6/15

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N2 - 7α-Acetylugandensolide together with thirteen known drimane-type sesquiterpenes have been isolated from Warbugia ugandensis bark extracts. Their structures were established by spectroscopic and physical methods as well as comparison with data available in the literature. The in vitro antimicrobial activities of the extracts and isolates were investigated against fungi and bacteria which infect sweet potato. Ethyl acetate extract exhibited the highest (P ≤ 0.05) antifungal and antibacterial activities compared to n-hexane and methanol extracts. Rhizopus stolonifer was more susceptible to ethyl acetate extract (inhibition zone = 24.5 mm) than Blitox which was used as a positive control. The minimum inhibitory concentration (MIC) for the isolates ranged between 12.5 and 200 μg/ml with the lowest MIC value of 12.5 μg/ml being observed with polygodial against Fusarium solani; warburganal against Aspergillus niger and F. solani; and mukaadial against A. niger.

AB - 7α-Acetylugandensolide together with thirteen known drimane-type sesquiterpenes have been isolated from Warbugia ugandensis bark extracts. Their structures were established by spectroscopic and physical methods as well as comparison with data available in the literature. The in vitro antimicrobial activities of the extracts and isolates were investigated against fungi and bacteria which infect sweet potato. Ethyl acetate extract exhibited the highest (P ≤ 0.05) antifungal and antibacterial activities compared to n-hexane and methanol extracts. Rhizopus stolonifer was more susceptible to ethyl acetate extract (inhibition zone = 24.5 mm) than Blitox which was used as a positive control. The minimum inhibitory concentration (MIC) for the isolates ranged between 12.5 and 200 μg/ml with the lowest MIC value of 12.5 μg/ml being observed with polygodial against Fusarium solani; warburganal against Aspergillus niger and F. solani; and mukaadial against A. niger.

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KW - Antifungal

KW - Canellaceae

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7α-Acetylugandensolide and antimicrobial properties of Warburgia ugandensis extracts and isolates against sweet potato pathogens

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Keywords

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