5-fluorouracil accumulation in green microalgae and its biogenetic transfer into ciliate protozoan

Ud Daula Asad, Gerd Pfister, Karl Werner Schramm

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

The study has demonstrated that anticancer drug 5-fluorouracil causes acute toxicity and interferes with the growth of green microalgae, Scenedesmus vacuolatus. It accumulates in microalgae biomass with bioaccumulation factor of 1.84 9 104 and further integrates into the DNA and RNA of microalgae. In addition, the labelled microalgae genome is transferred into protozoan Tetrahymena pyriformis on feeding and is retained in the food vacuoles of predator organisms. This biotransfer of labelled 5-fluorouracil via genomic material was evaluated using radioactivity in Tetrahymena cell pellets though radioactivity did not detect anticancer drug in the genome of the predator organism.

Original languageEnglish
Pages (from-to)548-554
Number of pages7
JournalBulletin of Environmental Contamination and Toxicology
Volume88
Issue number4
DOIs
StatePublished - Apr 2012

Keywords

  • Bioaccumulation Acute toxicity of 5-fluorouracil
  • Genetic transfer of 5-FU Microalgae

Fingerprint

Dive into the research topics of '5-fluorouracil accumulation in green microalgae and its biogenetic transfer into ciliate protozoan'. Together they form a unique fingerprint.

Cite this