3-Trifluoromethylthiophens from hexafluoroacetone

Klaus Burger, Brigitte Helmreich, Oliver Jendrewski

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

A one-pot procedure for the synthesis of 2-fluoro-3-trifluoromethyl- substituted thiophens 6 from 1-aryl-4,4-difluoro-3- trifluoromethylbut-3-en-1-one (3) and phosphorus pentasulfide is described. The fluorine atom at C-2 of compounds 6 undergoes nucleophilic displacement reactions.

Original languageEnglish
Pages (from-to)13-14
Number of pages2
JournalJournal of Fluorine Chemistry
Volume66
Issue number1
DOIs
StatePublished - Jan 1994

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