3-Substituted indolizine-1-carbonitrile derivatives as phosphatase inhibitors

Timo Weide; Lars Arve; Heino Prinz; Herbert Waldmann; Horst Kessler

doi:10.1016/j.bmcl.2005.09.051

3-Substituted indolizine-1-carbonitrile derivatives as phosphatase inhibitors

Timo Weide
, Lars Arve
, Heino Prinz
, Herbert Waldmann
, Horst Kessler

TUM Emeriti of Excellence

Technical University of Munich
Max Planck Inst. fur Molec. Physiol.
pro3dure medical GmbH

Research output: Contribution to journal › Article › peer-review

146 Scopus citations

Abstract

In the course of studies directed toward the discovery of novel scaffolds for medicinal application, we synthesized a series of 3-substituted indolizine-1-carbonitrile derivatives. Some of them displayed activity against MPtpA/MPtpB phosphatases which are involved in infectious diseases. We report here the solid-phase synthesis and antiphosphatase activity of a series of indolizines.

Original language	English
Pages (from-to)	59-63
Number of pages	5
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	16
Issue number	1
DOIs	https://doi.org/10.1016/j.bmcl.2005.09.051
State	Published - 1 Jan 2006

Keywords

3-Substituted indolizine-1-carbonitrile
Phosphatase
Solid-phase

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10.1016/j.bmcl.2005.09.051

Cite this

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abstract = "In the course of studies directed toward the discovery of novel scaffolds for medicinal application, we synthesized a series of 3-substituted indolizine-1-carbonitrile derivatives. Some of them displayed activity against MPtpA/MPtpB phosphatases which are involved in infectious diseases. We report here the solid-phase synthesis and antiphosphatase activity of a series of indolizines.",

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AU - Weide, Timo

AU - Arve, Lars

AU - Prinz, Heino

AU - Waldmann, Herbert

AU - Kessler, Horst

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AB - In the course of studies directed toward the discovery of novel scaffolds for medicinal application, we synthesized a series of 3-substituted indolizine-1-carbonitrile derivatives. Some of them displayed activity against MPtpA/MPtpB phosphatases which are involved in infectious diseases. We report here the solid-phase synthesis and antiphosphatase activity of a series of indolizines.

KW - 3-Substituted indolizine-1-carbonitrile

KW - Phosphatase

KW - Solid-phase

UR - https://www.scopus.com/pages/publications/27744514053

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DO - 10.1016/j.bmcl.2005.09.051

M3 - Article

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AN - SCOPUS:27744514053

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JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 1

ER -

3-Substituted indolizine-1-carbonitrile derivatives as phosphatase inhibitors

Abstract

Keywords

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