3-Substituted indolizine-1-carbonitrile derivatives as phosphatase inhibitors

Timo Weide; Lars Arve; Heino Prinz; Herbert Waldmann; Horst Kessler

doi:10.1016/j.bmcl.2005.09.051

3-Substituted indolizine-1-carbonitrile derivatives as phosphatase inhibitors

Timo Weide, Lars Arve, Heino Prinz, Herbert Waldmann, Horst Kessler

Default

Research output: Contribution to journal › Article › peer-review

139 Scopus citations

Abstract

In the course of studies directed toward the discovery of novel scaffolds for medicinal application, we synthesized a series of 3-substituted indolizine-1-carbonitrile derivatives. Some of them displayed activity against MPtpA/MPtpB phosphatases which are involved in infectious diseases. We report here the solid-phase synthesis and antiphosphatase activity of a series of indolizines.

Original language	English
Pages (from-to)	59-63
Number of pages	5
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	16
Issue number	1
DOIs	https://doi.org/10.1016/j.bmcl.2005.09.051
State	Published - 1 Jan 2006

Keywords

3-Substituted indolizine-1-carbonitrile
Phosphatase
Solid-phase

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.bmcl.2005.09.051

Cite this

@article{e4789d2c506140a0812677c99c71dc1d,

title = "3-Substituted indolizine-1-carbonitrile derivatives as phosphatase inhibitors",

abstract = "In the course of studies directed toward the discovery of novel scaffolds for medicinal application, we synthesized a series of 3-substituted indolizine-1-carbonitrile derivatives. Some of them displayed activity against MPtpA/MPtpB phosphatases which are involved in infectious diseases. We report here the solid-phase synthesis and antiphosphatase activity of a series of indolizines.",

keywords = "3-Substituted indolizine-1-carbonitrile, Phosphatase, Solid-phase",

author = "Timo Weide and Lars Arve and Heino Prinz and Herbert Waldmann and Horst Kessler",

year = "2006",

month = jan,

day = "1",

doi = "10.1016/j.bmcl.2005.09.051",

language = "English",

volume = "16",

pages = "59--63",

journal = "Bioorganic and Medicinal Chemistry Letters",

issn = "0960-894X",

publisher = "Elsevier Ltd.",

number = "1",

}

TY - JOUR

T1 - 3-Substituted indolizine-1-carbonitrile derivatives as phosphatase inhibitors

AU - Weide, Timo

AU - Arve, Lars

AU - Prinz, Heino

AU - Waldmann, Herbert

AU - Kessler, Horst

PY - 2006/1/1

Y1 - 2006/1/1

N2 - In the course of studies directed toward the discovery of novel scaffolds for medicinal application, we synthesized a series of 3-substituted indolizine-1-carbonitrile derivatives. Some of them displayed activity against MPtpA/MPtpB phosphatases which are involved in infectious diseases. We report here the solid-phase synthesis and antiphosphatase activity of a series of indolizines.

AB - In the course of studies directed toward the discovery of novel scaffolds for medicinal application, we synthesized a series of 3-substituted indolizine-1-carbonitrile derivatives. Some of them displayed activity against MPtpA/MPtpB phosphatases which are involved in infectious diseases. We report here the solid-phase synthesis and antiphosphatase activity of a series of indolizines.

KW - 3-Substituted indolizine-1-carbonitrile

KW - Phosphatase

KW - Solid-phase

UR - http://www.scopus.com/inward/record.url?scp=27744514053&partnerID=8YFLogxK

U2 - 10.1016/j.bmcl.2005.09.051

DO - 10.1016/j.bmcl.2005.09.051

M3 - Article

C2 - 16236508

AN - SCOPUS:27744514053

SN - 0960-894X

VL - 16

SP - 59

EP - 63

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 1

ER -

3-Substituted indolizine-1-carbonitrile derivatives as phosphatase inhibitors

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this