TY - JOUR
T1 - 256-slice CT angiographic evaluation of coronary artery bypass grafts
T2 - Effect of heart rate, heart rate variability and Z-axis location on image quality
AU - Gramer, Bettina M.
AU - Martinez, Patricia Diez
AU - Chin, Anne S.
AU - Sylvestre, Marie Pierre
AU - Larrivée, Sandra
AU - Stevens, Louis Mathieu
AU - Noiseux, Nicolas
AU - Soulez, Gilles
AU - Rummeny, Ernst J.
AU - Chartrand-Lefebvre, Carl
N1 - Funding Information:
The authors have the following interests: Carl Chartrand-Lefebvre has received grants from Bracco Diagnostics and has been involved in research collaboration with Philips Healthcare and Terarecon. Gilles Soulez has received grants from Biotronik, IDEV Technologies, Boston Scientific, Siemens and Bracco Diagnostics. CHUM: Provision of equipment from Philips Healthcare (radiologist contact for this support: CCL). None of the above grants relate to this specific study. There are no further patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials, as detailed online in the guide for authors.
PY - 2014/3/17
Y1 - 2014/3/17
N2 - Purpose: The objective of this study is to assess the effect of heart rate, heart rate variability and z-axis location on coronary artery bypass graft (CABG) image quality using a 256-slice computed tomography (CT) scanner. Methods: A total of 78 patients with 254 CABG (762 graft segments) were recruited to undergo CABG assessment with 256- slice CT and prospective ECG-gating. Two observers rated graft segments for image quality on a 5-point scale. Quantitative measurements were also made. Logistic and cumulative link mixed models were used to assess the predictors of graft image quality. Results: Graft image quality was judged as diagnostic (scores 5 (excellent), 4 (good) and 3 (moderate)) in 96.6% of the 762 segments. Interobserver agreement was excellent (kappa 0.90). Graft image quality was not affected by heart rate level. However, high heart rate variability was associated with an important and significant image quality deterioration (odds ratio 4.31; p = 0.036). Distal graft segments had significantly lower image quality scores than proximal segments (p # 0.02). Significantly higher noise was noted at the origin of the mammary grafts (p = 0.001), owing to streak artifacts from the shoulders. Conclusion: CABG imaging with 270-msec rotation 256-slice CT and prospective ECG-gating showed an adequate image quality in 96.6% of graft segments, and an excellent interobserver agreement. Graft image quality was not influenced by heart rate level. Image quality scores were however significantly decreased in patients with high heart rate variability, as well as in distal graft segments, which are closer to the heart. Copyright:
AB - Purpose: The objective of this study is to assess the effect of heart rate, heart rate variability and z-axis location on coronary artery bypass graft (CABG) image quality using a 256-slice computed tomography (CT) scanner. Methods: A total of 78 patients with 254 CABG (762 graft segments) were recruited to undergo CABG assessment with 256- slice CT and prospective ECG-gating. Two observers rated graft segments for image quality on a 5-point scale. Quantitative measurements were also made. Logistic and cumulative link mixed models were used to assess the predictors of graft image quality. Results: Graft image quality was judged as diagnostic (scores 5 (excellent), 4 (good) and 3 (moderate)) in 96.6% of the 762 segments. Interobserver agreement was excellent (kappa 0.90). Graft image quality was not affected by heart rate level. However, high heart rate variability was associated with an important and significant image quality deterioration (odds ratio 4.31; p = 0.036). Distal graft segments had significantly lower image quality scores than proximal segments (p # 0.02). Significantly higher noise was noted at the origin of the mammary grafts (p = 0.001), owing to streak artifacts from the shoulders. Conclusion: CABG imaging with 270-msec rotation 256-slice CT and prospective ECG-gating showed an adequate image quality in 96.6% of graft segments, and an excellent interobserver agreement. Graft image quality was not influenced by heart rate level. Image quality scores were however significantly decreased in patients with high heart rate variability, as well as in distal graft segments, which are closer to the heart. Copyright:
UR - http://www.scopus.com/inward/record.url?scp=84898622992&partnerID=8YFLogxK
U2 - 10.1371/journal.pone.0091861
DO - 10.1371/journal.pone.0091861
M3 - Article
C2 - 24637891
AN - SCOPUS:84898622992
SN - 1932-6203
VL - 9
JO - PLoS ONE
JF - PLoS ONE
IS - 3
M1 - e91861
ER -