218. Prostaglandin E I verhindert die Aspirin-bedingte Ischämie der Magenmucosa; ein Mechanismus der Cytoprotektion?

The mechanism by which prostaglandins (PG) exert their cytoprotective effect on the gastric mucosa is not known. Anesthetized rabbits received in Group (GR) I (n = 8) i.v. aspirin (ASA) (100 mg/kg as bolus, 66 mg/kg/h continuously), in GR II (n=10) NaCl and in Gr III PGE I (0.1 μg/kg/min) as an infusion for 120 min. Mucosal blood flow (MBF) was measured with radioactive microspheres. After 15 min, fundus MBF had decreased in GR I by 72.3+3.8% (+SEM) and after 120 min by 73.1+3.8% (P 0.05 vs % change in GR II and III). After 120 min, 19.8+7.6% of the mucosa had become hemorrhagic in GR I, 6.1+5.2% in GR II and 2.0+1.4% in GR III (P 0.05 vs GR II and III). We conclude that the cytoprotective effect of PGE I may be mediated through prevention of ASA-induced mucosal ischemia.