15.12 - Organometallic Chemistry of Gold-Based Drugs

Claudia Schmidt; Angela Casini

doi:10.1016/B978-0-12-820206-7.00032-9

15.12 - Organometallic Chemistry of Gold-Based Drugs

Claudia Schmidt, Angela Casini

Chair of Medicinal and Bioinorganic Chemistry

Technical University of Munich

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

1 Scopus citations

Abstract

In this article, a selection of results obtained on the synthesis, chemical properties and biological effects of two of the most extensively explored families of gold organometallics—namely, Au(I) N-heterocyclic carbenes and cyclometalated Au(III) compounds—is presented. Their structure-activity relationships and information on their modes of action as novel, experimental therapeutic agents are also discussed, which constitute the basis for future drug design.

Original language	English
Title of host publication	Comprehensive Organometallic Chemistry IV
Subtitle of host publication	Volume 1-15
Publisher	Elsevier
Pages	V15-297-V15-313
Volume	15
ISBN (Electronic)	9780128202067
DOIs	https://doi.org/10.1016/B978-0-12-820206-7.00032-9
State	Published - 1 Jan 2022

Keywords

Bacterial infections
Cancer
Cyclometalated compounds
G-quadruplexes
Gold
Leishmaniasis
Malaria
Metallodrugs
Mitochondria
N-heterocyclic carbenes
Nucleic acids
Organometallics
Proteins
Thioredoxin reductase

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/B978-0-12-820206-7.00032-9

Cite this

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title = "15.12 - Organometallic Chemistry of Gold-Based Drugs",

abstract = "In this article, a selection of results obtained on the synthesis, chemical properties and biological effects of two of the most extensively explored families of gold organometallics—namely, Au(I) N-heterocyclic carbenes and cyclometalated Au(III) compounds—is presented. Their structure-activity relationships and information on their modes of action as novel, experimental therapeutic agents are also discussed, which constitute the basis for future drug design.",

keywords = "Bacterial infections, Cancer, Cyclometalated compounds, G-quadruplexes, Gold, Leishmaniasis, Malaria, Metallodrugs, Mitochondria, N-heterocyclic carbenes, Nucleic acids, Organometallics, Proteins, Thioredoxin reductase",

author = "Claudia Schmidt and Angela Casini",

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doi = "10.1016/B978-0-12-820206-7.00032-9",

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T1 - 15.12 - Organometallic Chemistry of Gold-Based Drugs

AU - Schmidt, Claudia

AU - Casini, Angela

PY - 2022/1/1

Y1 - 2022/1/1

N2 - In this article, a selection of results obtained on the synthesis, chemical properties and biological effects of two of the most extensively explored families of gold organometallics—namely, Au(I) N-heterocyclic carbenes and cyclometalated Au(III) compounds—is presented. Their structure-activity relationships and information on their modes of action as novel, experimental therapeutic agents are also discussed, which constitute the basis for future drug design.

AB - In this article, a selection of results obtained on the synthesis, chemical properties and biological effects of two of the most extensively explored families of gold organometallics—namely, Au(I) N-heterocyclic carbenes and cyclometalated Au(III) compounds—is presented. Their structure-activity relationships and information on their modes of action as novel, experimental therapeutic agents are also discussed, which constitute the basis for future drug design.

KW - Bacterial infections

KW - Cancer

KW - Cyclometalated compounds

KW - G-quadruplexes

KW - Gold

KW - Leishmaniasis

KW - Malaria

KW - Metallodrugs

KW - Mitochondria

KW - N-heterocyclic carbenes

KW - Nucleic acids

KW - Organometallics

KW - Proteins

KW - Thioredoxin reductase

UR - http://www.scopus.com/inward/record.url?scp=85175383308&partnerID=8YFLogxK

U2 - 10.1016/B978-0-12-820206-7.00032-9

DO - 10.1016/B978-0-12-820206-7.00032-9

M3 - Chapter

AN - SCOPUS:85175383308

VL - 15

SP - V15-297-V15-313

BT - Comprehensive Organometallic Chemistry IV

PB - Elsevier

ER -

15.12 - Organometallic Chemistry of Gold-Based Drugs

Abstract

Keywords

UN SDGs

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