1;25 centric fusion recognition in the cattle chromosome by fluorescence in situ hybridization

Dariusz Ładoń, Sabina Solinas-Toldo, Ruedi Fries, Gerard F. Stranzinger

Research output: Contribution to journalArticlepeer-review

Abstract

Fluorescence in situ hybridization (FISH) experiments with specific probes for chromosome 29 and 25 were carried out on a Brown Swiss bull, previously diagnosed as a carrier of 1;29 centric fusion. The hybridization of the chromosome 29-specific probe (BMC 4216 - already located on 29q13), produced signals on two small acrocentrics, but not on the translocated chromosome. The signals appeared on the translocated chromosome and on a single chromosome 25 after hybridization of the chromosome-specific probe (BMC 3224 - previously located on 25q24). According to the actual nomenclature, the analysed aberration is a robertsonian translocation involving chromosomes 1 and 25.

Original languageEnglish
Pages (from-to)101-104
Number of pages4
JournalJournal of Applied Genetics
Volume37
Issue number1
StatePublished - 1996

Keywords

  • Cattle
  • Centric fusion
  • Fluorescence in situ hybridization

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