β-Sultams exhibit discrete binding preferences for diverse bacterial enzymes with nucleophilic residues

Roman Kolb; Nina C. Bach; Stephan A. Sieber

doi:10.1039/c3cc46002a

β-Sultams exhibit discrete binding preferences for diverse bacterial enzymes with nucleophilic residues

Roman Kolb
, Nina C. Bach
, Stephan A. Sieber

Chair of Organic Chemistry II

Technical University of Munich

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

β-Sultams are potent electrophiles that modify nucleophilic residues in selected enzyme active sites. We here identify and characterize some of the specific bacterial targets and show a unique inhibition of the azoreductase family.

Original language	English
Pages (from-to)	427-429
Number of pages	3
Journal	Chemical Communications
Volume	50
Issue number	4
DOIs	https://doi.org/10.1039/c3cc46002a
State	Published - 5 Dec 2014

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title = "β-Sultams exhibit discrete binding preferences for diverse bacterial enzymes with nucleophilic residues",

abstract = "β-Sultams are potent electrophiles that modify nucleophilic residues in selected enzyme active sites. We here identify and characterize some of the specific bacterial targets and show a unique inhibition of the azoreductase family.",

author = "Roman Kolb and Bach, \{Nina C.\} and Sieber, \{Stephan A.\}",

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AU - Kolb, Roman

AU - Bach, Nina C.

AU - Sieber, Stephan A.

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N2 - β-Sultams are potent electrophiles that modify nucleophilic residues in selected enzyme active sites. We here identify and characterize some of the specific bacterial targets and show a unique inhibition of the azoreductase family.

AB - β-Sultams are potent electrophiles that modify nucleophilic residues in selected enzyme active sites. We here identify and characterize some of the specific bacterial targets and show a unique inhibition of the azoreductase family.

UR - https://www.scopus.com/pages/publications/84889784217

U2 - 10.1039/c3cc46002a

DO - 10.1039/c3cc46002a

M3 - Article

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AN - SCOPUS:84889784217

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VL - 50

SP - 427

EP - 429

JO - Chemical Communications

JF - Chemical Communications

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ER -

β-Sultams exhibit discrete binding preferences for diverse bacterial enzymes with nucleophilic residues

Abstract

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