β-Sultams exhibit discrete binding preferences for diverse bacterial enzymes with nucleophilic residues

Roman Kolb; Nina C. Bach; Stephan A. Sieber

doi:10.1039/c3cc46002a

β-Sultams exhibit discrete binding preferences for diverse bacterial enzymes with nucleophilic residues

Roman Kolb, Nina C. Bach, Stephan A. Sieber

Chair of Organic Chemistry II

Technical University of Munich

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

β-Sultams are potent electrophiles that modify nucleophilic residues in selected enzyme active sites. We here identify and characterize some of the specific bacterial targets and show a unique inhibition of the azoreductase family.

Original language	English
Pages (from-to)	427-429
Number of pages	3
Journal	Chemical Communications
Volume	50
Issue number	4
DOIs	https://doi.org/10.1039/c3cc46002a
State	Published - 5 Dec 2014

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title = "β-Sultams exhibit discrete binding preferences for diverse bacterial enzymes with nucleophilic residues",

abstract = "β-Sultams are potent electrophiles that modify nucleophilic residues in selected enzyme active sites. We here identify and characterize some of the specific bacterial targets and show a unique inhibition of the azoreductase family.",

author = "Roman Kolb and Bach, {Nina C.} and Sieber, {Stephan A.}",

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N2 - β-Sultams are potent electrophiles that modify nucleophilic residues in selected enzyme active sites. We here identify and characterize some of the specific bacterial targets and show a unique inhibition of the azoreductase family.

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JO - Chemical Communications

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β-Sultams exhibit discrete binding preferences for diverse bacterial enzymes with nucleophilic residues

Abstract

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