@article{2cbbec23a0d54f04be9b372c1417134c,
title = "β-Site amyloid precursor protein-cleaving enzyme 1 activity is related to cerebrospinal fluid concentrations of sortilin-related receptor with A-type repeats, soluble amyloid precursor protein, and tau",
abstract = "Background: β-Site amyloid precursor protein (APP)-cleaving enzyme 1 (BACE1) activity determines the rate of APP cleavage and is therefore the main driver of amyloid b production, which is a pathological hallmark of Alzheimer's disease (AD). Methods: The present study explored the correlation between BACE1 activity and cerebrospinal fluid (CSF) markers of APP metabolism and axonal degeneration in 63 patients with mild AD and 12 healthy control subjects. Results: In the AD group, positive correlations between BACE1 activity and soluble APP b, the APP sorting receptor sortilin-related receptor with A-type repeats (also known as SorLA or LR11), and tau were detected. BACE1 activity was not associated with amyloid b1-42 or soluble APP a concentrations in the AD group, and no associations between BACE1 activity and any of the protein concentrations were found in the control group. Conclusion: Our results confirm the relevance of BACE1 and sortilin-related receptor with A-type repeats within the amyloid cascade and also provide a further piece of evidence for the link between amyloid and tau pathology in AD.",
keywords = "Alzheimer's disease, Amyloid cascade, B-secretase, Biomarker, Dementia",
author = "Amalia Tsolakidou and Panagiotis Alexopoulos and Guo, {Liang Hao} and Timo Grimmer and Christine Westerteicher and Martina Kratzer and Meizi Jiang and Hideaki Bujo and Francesco Roselli and Leante, {Maria Rosaria} and Paolo Livrea and Alexander Kurz and Robert Perneczky",
note = "Funding Information: The study was supported by the Kommission f{\"u}r Klinische Forschung of the Klinikum rechts der Isar M{\"u}nchen (grant numbers B06-09 , B08-10 ) and the Bund der Freunde der Technischen Universit{\"a}t M{\"u}nchen e.V. (grant number 22592 ). The sponsors did not have any role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; and preparation, review, or approval of the manuscript. The authors report no conflicts of interest. The authors thank Tamara Eisele for technical support, Professor Stefan Wagenpfeil (Institute of Medical Statistics and Epidemiology, Technische Universit{\"a}t M{\"u}nchen) for statistical advice, and Dorottya Ruisz for proofreading.",
year = "2013",
month = jul,
doi = "10.1016/j.jalz.2012.01.015",
language = "English",
volume = "9",
pages = "386--391",
journal = "Alzheimer's and Dementia",
issn = "1552-5260",
publisher = "John Wiley and Sons Inc.",
number = "4",
}
