β-lactones decrease the intracellular virulence of Listeria monocytogenes in macrophages

Thomas Böttcher; Stephan A. Sieber

doi:10.1002/cmdc.200900157

β-lactones decrease the intracellular virulence of Listeria monocytogenes in macrophages

Thomas Böttcher, Stephan A. Sieber

University of Munich

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

A chemical knockout of the virulence regulator ClpP by β-lactones in Listeria monocytogenes resulted in a reduced production of the major virulence factor listeriolysin O as well as of PI-phospholipase C. This led to a significant decrease in intracellular replication of the pathogen in mouse macrophage cells. (Chemical Equation Presented).

Original language	English
Pages (from-to)	1260-1263
Number of pages	4
Journal	ChemMedChem
Volume	4
Issue number	8
DOIs	https://doi.org/10.1002/cmdc.200900157
State	Published - 3 Aug 2009
Externally published	Yes

Keywords

Inhibitors
Invasion
Listeria
Virulence
β-lactones

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10.1002/cmdc.200900157

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KW - Virulence

KW - β-lactones

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β-lactones decrease the intracellular virulence of Listeria monocytogenes in macrophages

Abstract

Keywords

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