β-Catenin Up-Regulates the Expression of the Urokinase Plasminogen Activator in Human Colorectal Tumors

Elke Hiendlmeyer; Susanne Regus; Stella Wassermann; Falk Hlubek; Angela Haynl; Arno Dimmler; Claudia Koch; Claudia Knoll; Moniek Van Beest; Ute Reuning; Thomas Brabletz; Thomas Kirchner; Andreas Jung

doi:10.1158/0008-5472.CAN-3627-2

β-Catenin Up-Regulates the Expression of the Urokinase Plasminogen Activator in Human Colorectal Tumors

Elke Hiendlmeyer, Susanne Regus, Stella Wassermann, Falk Hlubek, Angela Haynl, Arno Dimmler, Claudia Koch, Claudia Knoll, Moniek Van Beest, Ute Reuning, Thomas Brabletz, Thomas Kirchner, Andreas Jung

Department of Gynecology

Research output: Contribution to journal › Article › peer-review

80 Scopus citations

Abstract

Expression of the urokinase plasminogen activator (uPA) increases during the progression of colorectal tumors from adenomas to carcinomas. The highest amounts of uPA are found at the invasion front of carcinomas, which also displays a strong expression of nuclear β-catenin and is therefore a region expressing β-catenin target genes at high levels. Here we show that β-catenin contributes to the transactivation of uPA. Therefore, β-catenin might have an impact on the capacity of colorectal tumors for invasion and metastasis, as well as dormancy, which are hallmarks of cancer.

Original language	English
Pages (from-to)	1209-1214
Number of pages	6
Journal	Cancer Research
Volume	64
Issue number	4
DOIs	https://doi.org/10.1158/0008-5472.CAN-3627-2
State	Published - 15 Feb 2004

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10.1158/0008-5472.CAN-3627-2

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title = "β-Catenin Up-Regulates the Expression of the Urokinase Plasminogen Activator in Human Colorectal Tumors",

abstract = "Expression of the urokinase plasminogen activator (uPA) increases during the progression of colorectal tumors from adenomas to carcinomas. The highest amounts of uPA are found at the invasion front of carcinomas, which also displays a strong expression of nuclear β-catenin and is therefore a region expressing β-catenin target genes at high levels. Here we show that β-catenin contributes to the transactivation of uPA. Therefore, β-catenin might have an impact on the capacity of colorectal tumors for invasion and metastasis, as well as dormancy, which are hallmarks of cancer.",

author = "Elke Hiendlmeyer and Susanne Regus and Stella Wassermann and Falk Hlubek and Angela Haynl and Arno Dimmler and Claudia Koch and Claudia Knoll and {Van Beest}, Moniek and Ute Reuning and Thomas Brabletz and Thomas Kirchner and Andreas Jung",

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T1 - β-Catenin Up-Regulates the Expression of the Urokinase Plasminogen Activator in Human Colorectal Tumors

AU - Hiendlmeyer, Elke

AU - Regus, Susanne

AU - Wassermann, Stella

AU - Hlubek, Falk

AU - Haynl, Angela

AU - Dimmler, Arno

AU - Koch, Claudia

AU - Knoll, Claudia

AU - Van Beest, Moniek

AU - Reuning, Ute

AU - Brabletz, Thomas

AU - Kirchner, Thomas

AU - Jung, Andreas

PY - 2004/2/15

Y1 - 2004/2/15

N2 - Expression of the urokinase plasminogen activator (uPA) increases during the progression of colorectal tumors from adenomas to carcinomas. The highest amounts of uPA are found at the invasion front of carcinomas, which also displays a strong expression of nuclear β-catenin and is therefore a region expressing β-catenin target genes at high levels. Here we show that β-catenin contributes to the transactivation of uPA. Therefore, β-catenin might have an impact on the capacity of colorectal tumors for invasion and metastasis, as well as dormancy, which are hallmarks of cancer.

AB - Expression of the urokinase plasminogen activator (uPA) increases during the progression of colorectal tumors from adenomas to carcinomas. The highest amounts of uPA are found at the invasion front of carcinomas, which also displays a strong expression of nuclear β-catenin and is therefore a region expressing β-catenin target genes at high levels. Here we show that β-catenin contributes to the transactivation of uPA. Therefore, β-catenin might have an impact on the capacity of colorectal tumors for invasion and metastasis, as well as dormancy, which are hallmarks of cancer.

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AN - SCOPUS:10744221160

SN - 0008-5472

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JO - Cancer Research

JF - Cancer Research

IS - 4

ER -

β-Catenin Up-Regulates the Expression of the Urokinase Plasminogen Activator in Human Colorectal Tumors

Abstract

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