β-Catenin Up-Regulates the Expression of the Urokinase Plasminogen Activator in Human Colorectal Tumors

Elke Hiendlmeyer, Susanne Regus, Stella Wassermann, Falk Hlubek, Angela Haynl, Arno Dimmler, Claudia Koch, Claudia Knoll, Moniek Van Beest, Ute Reuning, Thomas Brabletz, Thomas Kirchner, Andreas Jung

Research output: Contribution to journalArticlepeer-review

79 Scopus citations

Abstract

Expression of the urokinase plasminogen activator (uPA) increases during the progression of colorectal tumors from adenomas to carcinomas. The highest amounts of uPA are found at the invasion front of carcinomas, which also displays a strong expression of nuclear β-catenin and is therefore a region expressing β-catenin target genes at high levels. Here we show that β-catenin contributes to the transactivation of uPA. Therefore, β-catenin might have an impact on the capacity of colorectal tumors for invasion and metastasis, as well as dormancy, which are hallmarks of cancer.

Original languageEnglish
Pages (from-to)1209-1214
Number of pages6
JournalCancer Research
Volume64
Issue number4
DOIs
StatePublished - 15 Feb 2004
Externally publishedYes

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