Abstract
This review provides a brief overview of the β-adrenergic signal transduction system in the mammalian heart and its alterations in heart failure. Furthermore, the mechanisms underlying the detrimental effect of chronic β-adrenergic stimulation, the beneficial effects of β-blockade in heart failure, and the emerging role of pharmacogenomics in this field will be discussed.
Original language | English |
---|---|
Pages (from-to) | 183-191 |
Number of pages | 9 |
Journal | Heart Failure Clinics |
Volume | 1 |
Issue number | 2 |
DOIs | |
State | Published - Jul 2005 |
Externally published | Yes |