Über die Wirkung einer adrenergen β-Receptorenblockade auf die Kontraktilität des gesunden menschlichen Herzens

H. Lydtin, K. Schnelle, N. Zöllner

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The effect of an intravenously administered β-receptor blocking agent (propranolol) was studied at rest by synchronous recordings of electrocardiogram, carotid pulse, ulf-ballistocardiogram and phonocardiogram in 20 healthy volunteers (age 18-27). Our parameters of contractility showed a negative inotropic and chronotropic effect when 5 (or 10 mg) propranolol were given. Heart rate and systolic pressure decreased, whereas diastolic pressure changed only very little. Our results are consistent with a tonic adrenergic stimulus of the normal human heart at rest and with a direct effect of propranolol on the myocardium aside from the blockade. After β-blockade no change of the positive inotropic action of digitalis was found. The negative chronotropic effect of digitalis was reduced after β-blockade. Our results provide positive evidence, that ulfballistocardiography can be used combined with other methods in pharmacological studies of cardiotropic drugs.

Original languageGerman
Pages (from-to)67-78
Number of pages12
JournalZeitschrift für die gesamte experimentelle Medizin einschließlich experimentelle Chirurgie
Issue number1
StatePublished - Mar 1967
Externally publishedYes

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