Abstract
The effect of an intravenously administered β-receptor blocking agent (propranolol) was studied at rest by synchronous recordings of electrocardiogram, carotid pulse, ulf-ballistocardiogram and phonocardiogram in 20 healthy volunteers (age 18-27). Our parameters of contractility showed a negative inotropic and chronotropic effect when 5 (or 10 mg) propranolol were given. Heart rate and systolic pressure decreased, whereas diastolic pressure changed only very little. Our results are consistent with a tonic adrenergic stimulus of the normal human heart at rest and with a direct effect of propranolol on the myocardium aside from the blockade. After β-blockade no change of the positive inotropic action of digitalis was found. The negative chronotropic effect of digitalis was reduced after β-blockade. Our results provide positive evidence, that ulfballistocardiography can be used combined with other methods in pharmacological studies of cardiotropic drugs.
| Original language | German |
|---|---|
| Pages (from-to) | 67-78 |
| Number of pages | 12 |
| Journal | Zeitschrift für die gesamte experimentelle Medizin einschließlich experimentelle Chirurgie |
| Volume | 143 |
| Issue number | 1 |
| DOIs | |
| State | Published - Mar 1967 |
| Externally published | Yes |
