FOR 5795 "HyperMet" Effects of skeletal muscle hypertrophy and atrophy on metabolic health

Global skeletal muscle hypertrophy has anti-obesity, anti-diabetes, anti-osteoporosis,
and possibly anti-tumor growth effects. Conversely, global skeletal muscle
atrophy is typically associated with fat gain, insulin resistance, osteoporosis, and poor
outcomes in cancer patients. The aim of the HyperMet research unit is to investigate the
underlying metabolic mechanisms on three levels that are first intercellular metabolism, second
muscular metabolite exchange, and third inter-organ metabolism and metabolic health. We will do
so using advanced methods of metabolic research such as isotope-labeled tracer-based flux
analysis, metabolic imaging, and arteriovenous metabolomics.

HyperMet research examines the impact of muscle growth (hypertrophy) and muscle loss (atrophy) on metabolism. Increased muscle mass reduces the risk of obesity, diabetes, osteoporosis, and potentially cancer. We are exploring the underlying metabolic processes to develop new strategies for prevention and everyday life.