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Wolfgang Wurst

Prof. Dr. rer. nat.

Former affiliation
1984 …2026

Research activity per year

Personal profile

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  1. SDG 3 - Good Health and Well-being
    SDG 3 Good Health and Well-being
  2. SDG 6 - Clean Water and Sanitation
    SDG 6 Clean Water and Sanitation
  3. SDG 7 - Affordable and Clean Energy
    SDG 7 Affordable and Clean Energy

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Collaborations and top research areas from the last five years

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  • A fin-loop-like structure in GPX4 underlies neuroprotection from ferroptosis

    Lorenz, S. M., Wahida, A., Bostock, M. J., Seibt, T., Santos Dias Mourão, A., Levkina, A., Trümbach, D., Soudy, M., Emler, D., Rothammer, N., Woo, M. S., Sonner, J. K., Novikova, M., Henkelmann, B., Aldrovandi, M., Kaemena, D. F., Mishima, E., Vermonden, P., Zong, Z. & Chen, D. & 53 others, Nakamura, T., Ito, J., Doll, S., Proneth, B., Bürkle, E., Rizzollo, F., Escamilla Ayala, A., Napolitano, V., Kolonko-Adamska, M., Gaussmann, S., Merl-Pham, J., Hauck, S., Pertek, A., Orschmann, T., van San, E., Vanden Berghe, T., Hass, D., Maida, A., Frenz, J. M., Pedrera, L., Dolga, A., Kraiger, M., Hrabé de Angelis, M., Fuchs, H., Ebert, G., Lenberg, J., Friedman, J., Scale, C., Agostinis, P., Zimprich, A., Vogt-Weisenhorn, D., Garrett, L., Hölter, S. M., Wurst, W., Glaab, E., Lewerenz, J., Popper, B., Sieben, C., Steinacker, P., Zischka, H., Garcia-Saez, A. J., Tietze, A., Ramesh, S. K., Ayton, S., Vincendeau, M., Friese, M. A., Wigby, K., Sattler, M., Mann, M., Ingold, I., Jayavelu, A. K., Popowicz, G. M. & Conrad, M., 8 Jan 2026, In: Cell. 189, 1, p. 287-306.e35

    Research output: Contribution to journal › Article › peer-review

    Open Access
    20 Scopus citations

  • TREM2 expression level is critical for microglial state, metabolic capacity and efficacy of TREM2 agonism

    Feiten, A. F., Dahm, K., Schlepckow, K., van Lengerich, B., Suh, J. H., Reifschneider, A., Wefers, B., Bartos, L. M., Wind-Mark, K., de Weerd, L., Ulas, T., De-Domenico, E., Grundschöttel, P., Paulusch, S., Tast, B., Honda, T., Müller, S. A., Becker, M., Khalin, I. & Ricci, A. & 21 others, Liesz, A., Brunner, B., Krenner, C., Buschmann, K., Nuscher, B., Spieth, L., Junker, N., Berghoff, S. A., Davis, S. S., Neher, J. J., Wurst, W., Plesnila, N., Lewcock, J. W., Simons, M., Lichtenthaler, S. F., Di Paolo, G., Brendel, M., Capell, A., Monroe, K. M., Schultze, J. L. & Haass, C., Dec 2026, In: Nature Communications. 17, 1, 2002.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    8 Scopus citations

  • VMAT2 dysfunction impairs vesicular dopamine uptake, driving its oxidation and α-synuclein pathology in DJ-1– linked Parkinson’s neurons

    Heger, L. M., Gubinelli, F., Huber, A. J., Cardona-Alberich, A., Rovere, M., Matti, U., Müller, S. A., Nagaraja, S. R., Jaschkowitz, L., Schifferer, M., Wurst, W., Lichtenthaler, S. F., Behrends, C., Sambandan, S. & Burbulla, L. F., 11 Feb 2026, In: Science Advances. 12, 7, p. 1-21 21 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    4 Scopus citations

  • A bipolar disorder-associated missense variant alters adenylyl cyclase 2 activity and promotes mania-like behavior

    Sen, P., Ortiz, O., Brivio, E., Menegaz, D., Sotillos Elliott, L., Du, Y., Ries, C., Chen, A., Wurst, W., Lopez, J. P., Eder, M. & Deussing, J. M., Jan 2025, In: Molecular Psychiatry. 30, 1, p. 97-110 14 p., 18008.

    Research output: Contribution to journal › Article › peer-review

    6 Scopus citations

  • Erratum: Apolipoprotein E aggregation in microglia initiates Alzheimer's disease pathology by seeding β-amyloidosis (Immunity (2024) 57(11) (2651–2668.e12), (S1074761324004588), (10.1016/j.immuni.2024.09.014))

    Kaji, S., Berghoff, S. A., Spieth, L., Schlaphoff, L., Sasmita, A. O., Vitale, S., Büschgens, L., Kedia, S., Zirngibl, M., Nazarenko, T., Damkou, A., Hosang, L., Depp, C., Kamp, F., Scholz, P., Ewers, D., Giera, M., Ischebeck, T., Wurst, W. & Wefers, B. & 9 others, Schifferer, M., Willem, M., Nave, K. A., Haass, C., Arzberger, T., Jäkel, S., Wirths, O., Saher, G. & Simons, M., 14 Jan 2025, In: Immunity. 58, 1, p. 263 1 p.

    Research output: Contribution to journal › Comment/debate

    Open Access
    2 Scopus citations
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