Viktor Magdolen

2025

The chemokine CX3CL1 promotes intraperitoneal tumour growth despite enhanced T-cell recruitment in ovarian cancer

Seitz, S., Dreyer, T. F., Stange, C., Steiger, K., Wohlleber, D., Anton, M., Pham, T. A., Sauter-Peschke, D., Reuning, U., Multhoff, G., Weichert, W., Kiechle, M., Magdolen, V. & Bronger, H., Feb 2025, In: Neoplasia. 60, 101130.

Research output: Contribution to journal › Article › peer-review

Open Access

2023

Herpes simplex virus alters Alzheimer's disease biomarkers - A hypothesis paper

Goldhardt, O., Freiberger, R., Dreyer, T., Willner, L., Yakushev, I., Ortner, M., Förstl, H., Diehl-Schmid, J., Milz, E., Priller, J., Ramirez, A., Magdolen, V., Thaler, M. & Grimmer, T., May 2023, In: Alzheimer's and Dementia. 19, 5, p. 2117-2134 18 p.

Research output: Contribution to journal › Article › peer-review

Open Access

13 Scopus citations

Repression of miR-146a in predicting poor treatment outcome in triple-negative breast cancer

Panoutsopoulou, K., Liu, Y., Avgeris, M., Dreyer, T., Dorn, J., Magdolen, V. & Scorilas, A., Apr 2023, In: Clinical Biochemistry. 114, p. 43-51 9 p.

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

tRNA-derived small RNA 3′U-tRF^ValCAC promotes tumour migration and early progression in ovarian cancer

Panoutsopoulou, K., Magkou, P., Dreyer, T., Dorn, J., Obermayr, E., Mahner, S., van Gorp, T., Braicu, I., Magdolen, V., Zeillinger, R., Avgeris, M. & Scorilas, A., Feb 2023, In: European Journal of Cancer. 180, p. 134-145 12 p.

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

2022

A Pair of Prognostic Biomarkers in Triple-Negative Breast Cancer: KLK10 and KLK11 mRNA Expression

Liu, Y., Gong, W., Preis, S., Dorn, J., Kiechle, M., Reuning, U., Magdolen, V. & Dreyer, T. F., Oct 2022, In: Life. 12, 10, 1517.

Research output: Contribution to journal › Article › peer-review

Open Access

7 Scopus citations

CXCL9 inhibits tumour growth and drives anti-PD-L1 therapy in ovarian cancer

Seitz, S., Dreyer, T. F., Stange, C., Steiger, K., Bräuer, R., Scheutz, L., Multhoff, G., Weichert, W., Kiechle, M., Magdolen, V. & Bronger, H., 1 Jun 2022, In: British Journal of Cancer. 126, 10, p. 1470-1480 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

41 Scopus citations

Improving the selectivity of 3-amidinophenylalanine-derived matriptase inhibitors

Pilgram, O., Keils, A., Benary, G. E., Müller, J., Merkl, S., Ngaha, S., Huber, S., Chevillard, F., Harbig, A., Magdolen, V., Heine, A., Böttcher-Friebertshäuser, E. & Steinmetzer, T., 5 Aug 2022, In: European Journal of Medicinal Chemistry. 238, 114437.

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Trna^glygcc-derived internal fragment (I-trf-glygcc) in ovarian cancer treatment outcome and progression

Panoutsopoulou, K., Dreyer, T., Dorn, J., Obermayr, E., Mahner, S., van Gorp, T., Braicu, I., Zeillinger, R., Magdolen, V., Avgeris, M. & Scorilas, A., 1 Jan 2022, In: Cancers. 14, 1, 24.

Research output: Contribution to journal › Article › peer-review

Open Access

37 Scopus citations

2021

Elevated levels of both microRNA 378 (miR-378) and kallikrein-related peptidase 4 (KLK4) mRNA are associated with an unfavorable prognosis in triple-negative breast cancer

Gong, W., Zhu, C., Liu, Y., Muckenhuber, A., Bronger, H., Scorilas, A., Kiechle, M., Dorn, J., Magdolen, V. & Dreyer, T., 2021, In: American Journal of Translational Research. 13, 3, p. 1594-1606 13 p.

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Epigenetic modulators combination with chemotherapy in breast cancer cells

Ari, F., Napieralski, R., Akgun, O., Magdolen, V. & Ulukaya, E., Jun 2021, In: Cell Biochemistry and Function. 39, 4, p. 571-583 13 p.

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Kallikrein-related peptidase 6 is associated with the tumour microenvironment of pancreatic ductal adenocarcinoma

Candido, J. B., Maiques, O., Boxberg, M., Kast, V., Peerani, E., Tomás-bort, E., Weichert, W., Sananes, A., Papo, N., Magdolen, V., Sanz-moreno, V. & Loessner, D., 2 Aug 2021, In: Cancers. 13, 16, 3969.

Research output: Contribution to journal › Article › peer-review

Open Access

14 Scopus citations

PITX2 DNA-Methylation: Predictive versus Prognostic Value for Anthracycline-Based Chemotherapy in Triple-Negative Breast Cancer Patients

Napieralski, R., Schricker, G., Auer, G., Aubele, M., Perkins, J., Magdolen, V., Ulm, K., Hamann, M., Walch, A., Weichert, W., Kiechle, M. & Wilhelm, O. G., 1 Oct 2021, In: Breast Care. 16, 5, p. 523-531 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Scopus citations

Rab31-dependent regulation of transforming growth factor ß expression in breast cancer cells

Soelch, S., Beaufort, N., Loessner, D., Kotzsch, M., Reuning, U., Luther, T., Kirchner, T. & Magdolen, V., Dec 2021, In: Molecular Medicine. 27, 1, 158.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Scopus citations

Substrate-biased activity-based probes identify proteases that cleave receptor CDCP1

Kryza, T., Khan, T., Lovell, S., Harrington, B. S., Yin, J., Porazinski, S., Pajic, M., Koistinen, H., Rantala, J. K., Dreyer, T., Magdolen, V., Reuning, U., He, Y., Tate, E. W. & Hooper, J. D., Jul 2021, In: Nature Chemical Biology. 17, 7, p. 776-783 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

19 Scopus citations

The chemokine CX3CL1 improves trastuzumab efficacy in HER2 low-expressing cancer in vitro and in vivo

Dreyer, T. F., Kuhn, S., Stange, C., Heithorst, N., Schilling, D., Jelsma, J., Sievert, W., Seitz, S., Stangl, S., Hapfelmeier, A., Noske, A., Wege, A. K., Weichert, W., Eurgen Ruland, J., Schmitt, M., Dorn, J., Kiechle, M., Reuning, U., Magdolen, V. & Multhoff, G. & 1 others, Bronger, H., Jul 2021, In: Cancer Immunology Research. 9, 7, p. 779-789 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

18 Scopus citations

2020

Klk4 induces anti-tumor effects in human xenograft mouse models of orthotopic and metastatic prostate cancer

Tse, B. W. C., Kryza, T., Yeh, M. C., Dong, Y., Sokolowski, K. A., Walpole, C., Dreyer, T., Felber, J., Harris, J., Magdolen, V., Russell, P. J. & Clements, J. A., Dec 2020, In: Cancers. 12, 12, p. 1-15 15 p., 3501.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Scopus citations

miR-181a overexpression predicts the poor treatment response and early-progression of serous ovarian cancer patients

Panoutsopoulou, K., Avgeris, M., Magkou, P., Mavridis, K., Dreyer, T., Dorn, J., Obermayr, E., Reinthaller, A., Michaelidou, K., Mahner, S., Vergote, I., Loverix, L., Braicu, I., Sehouli, J., Zeillinger, R., Magdolen, V. & Scorilas, A., 15 Dec 2020, In: International Journal of Cancer. 147, 12, p. 3560-3573 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

12 Scopus citations

MiR-203 is an independent molecular predictor of prognosis and treatment outcome in ovarian cancer: A multi-institutional study

Panoutsopoulou, K., Avgeris, M., Mavridis, K., Dreyer, T., Dorn, J., Obermayr, E., Reinthaller, A., Michaelidou, K., Mahner, S., Vergote, I., Vanderstichele, A., Braicu, I., Sehouli, J., Zeillinger, R., Magdolen, V. & Scorilas, A., Apr 2020, In: Carcinogenesis. 41, 4, p. 442-451 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

13 Scopus citations

Prognostic value of kallikrein-related peptidase 12 (KLK12) mRNA expression in triple-negative breast cancer patients

Gong, W., Liu, Y., Preis, S., Geng, X., Petit-Courty, A., Kiechle, M., Muckenhuber, A., Dreyer, T., Dorn, J., Courty, Y. & Magdolen, V., 7 Feb 2020, In: Molecular Medicine. 26, 1, 19.

Research output: Contribution to journal › Article › peer-review

Open Access

9 Scopus citations

Prognostic value of kallikrein-related peptidase 7 (KLK7) mRNA expression in advanced high-grade serous ovarian cancer

Gong, W., Liu, Y., Diamandis, E. P., Kiechle, M., Bronger, H., Dorn, J., Dreyer, T. & Magdolen, V., 1 Dec 2020, In: Journal of Ovarian Research. 13, 1, 125.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Scopus citations

2019

Characterization of kallikrein-related peptidase 4 (KLK4) mRNA expression in tumor tissue of advanced high-grade serous ovarian cancer patients

Gong, W., Liu, Y., Seidl, C., Dreyer, T., Drecoll, E., Kotzsch, M., Bronger, H., Dorn, J. & Magdolen, V., Feb 2019, In: PLoS ONE. 14, 2, e0212968.

Research output: Contribution to journal › Article › peer-review

Open Access

17 Scopus citations

Integration of Two In-depth Quantitative Proteomics Approaches Determines the Kallikrein-related Peptidase 7 (KLK7) Degradome in Ovarian Cancer Cell Secretome

Silva, L. M., Kryza, T., Stoll, T., Hoogland, C., Dong, Y., Stephens, C. R., Hastie, M. L., Magdolen, V., Kleifeld, O., Gorman, J. J. & Clements, J. A., May 2019, In: Molecular and Cellular Proteomics. 18, 5, p. 818-836 19 p.

Research output: Contribution to journal › Article › peer-review

Open Access

18 Scopus citations

Kallikrein-related peptidases 6 and 10 are elevated in cerebrospinal fluid of patients with Alzheimer's disease and associated with CSF-TAU and FDG-PET

Goldhardt, O., Warnhoff, I., Yakushev, I., Begcevic, I., Förstl, H., Magdolen, V., Soosaipillai, A., Diamandis, E., Alexopoulos, P. & Grimmer, T., 27 Aug 2019, In: Translational Neurodegeneration. 8, 1, 25.

Research output: Contribution to journal › Article › peer-review

Open Access

20 Scopus citations

Quantitative assessment and clinical relevance of kallikrein-related peptidase 5 mRNA expression in advanced high-grade serous ovarian cancer

Gong, W., Liu, Y., Seidl, C., Diamandis, E. P., Kiechle, M., Drecoll, E., Kotzsch, M., Magdolen, V. & Dorn, J., 15 Jul 2019, In: BMC Cancer. 19, 1, 696.

Research output: Contribution to journal › Article › peer-review

Open Access

8 Scopus citations

2018

Activation and activity of glycosylated KLKs 3, 4 and 11

Guo, S., Briza, P., Magdolen, V., Brandstetter, H. & Goettig, P., 25 Sep 2018, In: Biological Chemistry. 399, 9, p. 1009-1022 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

9 Scopus citations

Advanced high-grade serous ovarian cancer: inverse association of KLK13 and KLK14 mRNA levels in tumor tissue and patients’ prognosis

Dettmar, L., Ahmed, N., Kotzsch, M., Diersch, S., Napieralski, R., Darmoul, D., Schmitt, M., Weichert, W., Kiechle, M., Dorn, J. & Magdolen, V., 1 Jun 2018, In: Journal of Cancer Research and Clinical Oncology. 144, 6, p. 1109-1118 10 p.

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Brain-related proteins as potential CSF biomarkers of Alzheimer's disease: A targeted mass spectrometry approach

Begcevic, I., Brinc, D., Brown, M., Martinez-Morillo, E., Goldhardt, O., Grimmer, T., Magdolen, V., Batruch, I. & Diamandis, E. P., 30 Jun 2018, In: Journal of Proteomics. 182, p. 12-20 9 p.

Research output: Contribution to journal › Article › peer-review

68 Scopus citations

Clinical performance of an analytically validated assay in comparison to microarray technology to assess PITX2 DNA-methylation in breast cancer

Schricker, G., Napieralski, R., Noske, A., Piednoir, E., Manner, O., Schüren, E., Lauber, J., Perkins, J., Magdolen, V., Schmitt, M., Ulm, K., Weichert, W., Kiechle, M., Martens, J. W. M. & Wilhelm, O. G., 1 Dec 2018, In: Scientific Reports. 8, 1, 16861.

Research output: Contribution to journal › Article › peer-review

Open Access

13 Scopus citations

Insights into the activity control of the kallikrein-related peptidase 6: Small-molecule modulators and allosterism

Soualmia, F., Bosc, E., Amiri, S. A., Stratmann, D., Magdolen, V., Darmoul, D., Reboud-Ravaux, M. & El Amri, C., 25 Sep 2018, In: Biological Chemistry. 399, 9, p. 1073-1078 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Scopus citations

Kallikrein-related peptidase 7 overexpression in melanoma cells modulates cell adhesion leading to a malignant phenotype

Haddada, M., Draoui, H., Deschamps, L., Walker, F., Delaunay, T., Brattsand, M., Magdolen, V. & Darmoul, D., 25 Sep 2018, In: Biological Chemistry. 399, 9, p. 1099-1105 7 p.

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Kallikrein-related peptidases 4, 5, 6 and 7 regulate tumour-associated factors in serous ovarian cancer

Wang, P., Magdolen, V., Seidl, C., Dorn, J., Drecoll, E., Kotzsch, M., Yang, F., Schmitt, M., Schilling, O., Rockstroh, A., Clements, J. A. & Loessner, D., 2 Oct 2018, In: British Journal of Cancer. 119, 7, p. 823-831 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

28 Scopus citations

PITX2 DNA-methylation predicts response to anthracycline-based adjuvant chemotherapy in triple-negative breast cancer patients

Absmaier, M., Napieralski, R., Schuster, T., Aubele, M., Walch, A., Magdolen, V., Dorn, J., Gross, E., Harbeck, N., Noske, A., Kiechle, M. & Schmitt, M., Mar 2018, In: International Journal of Oncology. 52, 3, p. 755-767 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

27 Scopus citations

Structural determinants of specificity and regulation of activity in the allosteric loop network of human KLK8/neuropsin

Debela, M., Magdolen, V., Skala, W., Elsässer, B., Schneider, E. L., Craik, C. S., Biniossek, M. L., Schilling, O., Bode, W., Brandstetter, H. & Goettig, P., 1 Dec 2018, In: Scientific Reports. 8, 1, 10705.

Research output: Contribution to journal › Article › peer-review

Open Access

11 Scopus citations

2017

Aberrant expression of kallikrein-related peptidase 7 is correlated with human melanoma aggressiveness by stimulating cell migration and invasion

Delaunay, T., Deschamps, L., Haddada, M., Walker, F., Soosaipillai, A., Soualmia, F., El Amri, C., Diamandis, E. P., Brattsand, M., Magdolen, V. & Darmoul, D., Oct 2017, In: Molecular Oncology. 11, 10, p. 1330-1347 18 p.

Research output: Contribution to journal › Article › peer-review

Open Access

18 Scopus citations

Clinical relevance of kallikrein-related peptidase 9, 10, 11, and 15 mRNA expression in advanced high-grade serous ovarian cancer

Geng, X., Liu, Y., Diersch, S., Kotzsch, M., Grill, S., Weichert, W., Kiechle, M., Magdolen, V. & Dorn, J., Nov 2017, In: PLoS ONE. 12, 11, e0186847.

Research output: Contribution to journal › Article › peer-review

Open Access

25 Scopus citations

Inverse association of rab31 and mucin-1 (CA15-3) antigen levels in estrogen receptor-positive (ER+) breast cancer tissues with clinicopathological parameters and patients' prognosis

Kotzsch, M., Kirchner, T., Soelch, S., Schäfer, S., Friedrich, K., Baretton, G., Magdolen, V. & Luther, T., 2017, In: American Journal of Cancer Research. 7, 9, p. 1959-1970 12 p.

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Pericellular regulation of prostate cancer expressed kallikrein-related peptidases and matrix metalloproteinases by cell surface serine proteases

Reid, J. C., Matsika, A., Davies, C. M., He, Y., Broomfield, A., Bennett, N. C., Magdolen, V., Srinivasan, B., Clements, J. A. & Hooper, J. D., 2017, In: American Journal of Cancer Research. 7, 11, p. 2257-2274 18 p.

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Phosphoserine aminotransferase 1 is associated to poor outcome on tamoxifen therapy in recurrent breast cancer

De Marchi, T., Timmermans, M. A., Sieuwerts, A. M., Smid, M., Look, M. P., Grebenchtchikov, N., Sweep, F. C. G. J., Smits, J. G., Magdolen, V., Van Deurzen, C. H. M., Foekens, J. A., Umar, A. & Martens, J. W., 1 Dec 2017, In: Scientific Reports. 7, 1, 2099.

Research output: Contribution to journal › Article › peer-review

Open Access

38 Scopus citations

Plasmin(ogen) serves as a favorable biomarker for prediction of survival in advanced high-grade serous ovarian cancer

Zhao, S., Dorn, J., Napieralski, R., Walch, A., DIersch, S., Kotzsch, M., Ahmed, N., Hooper, J. D., Kiechle, M., Schmitt, M. & Magdolen, V., 27 Jun 2017, In: Biological Chemistry. 398, 7, p. 765-773 9 p.

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Tissue kallikrein-related peptidase 4 (KLK4), a novel biomarker in triple-negative breast cancer

Yang, F., Aubele, M., Walch, A., Gross, E., Napieralski, R., Zhao, S., Ahmed, N., Kiechle, M., Reuning, U., Dorn, J., Sweep, F., Magdolen, V. & Schmitt, M., 26 Sep 2017, In: Biological Chemistry. 398, 10, p. 1151-1164 14 p.

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

2016

A single glycan at the 99-loop of human kallikrein-related peptidase 2 regulates activation and enzymatic activity

Guo, S., Skala, W., Magdolen, V., Briza, P., Biniossek, M. L., Schilling, O., Kellermann, J., Brandstetter, H. & Goettig, P., 8 Jan 2016, In: Journal of Biological Chemistry. 291, 2, p. 593-604 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

23 Scopus citations

Assessment of kallikrein-related peptidase 5 (KLK5) protein expression in tumor tissue of advanced ovarian cancer patients by immunohistochemistry and ELISA: Correlation with clinical outcome

Dorn, J., Yassouridis, A., Walch, A., Diamandis, E. P., Schmitt, M., Kiechle, M., Wang, P., Drecoll, E., Schmalfeldt, B., Loessner, D., Kotzsch, M. & Magdolen, V., 2016, In: American Journal of Cancer Research. 6, 1, p. 61-70 10 p.

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Clinical relevance of kallikrein-related peptidase 6 (KLK6) and 8 (KLK8) mRNA expression in advanced serous ovarian cancer

Ahmed, N., Dorn, J., Napieralski, R., Drecoll, E., Kotzsch, M., Goettig, P., Zein, E., Avril, S., Kiechle, M., Diamandis, E. P., Schmitt, M. & Magdolen, V., 1 Dec 2016, In: Biological Chemistry. 397, 12, p. 1265-1276 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

28 Scopus citations

In vitro evidence that KLK14 regulates the components of the HGF/Met axis, pro-HGF and HGF-activator inhibitor 1A and 1B

Reid, J. C., Bennett, N. C., Stephens, C. R., Carroll, M. L., Magdolen, V., Clements, J. A. & Hooper, J. D., 1 Dec 2016, In: Biological Chemistry. 397, 12, p. 1299-1305 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

10 Scopus citations

Preclinical evaluation of [¹¹¹In]MICA-401, an activity-based probe for SPECT imaging of in vivo uPA activity

Vangestel, C., Thomae, D., Van Soom, J., Ides, J., wyffels, L., Pauwels, P., Stroobants, S., Van der Veken, P., Magdolen, V., Joossens, J., Augustyns, K. & Staelens, S., 1 Nov 2016, In: Contrast Media and Molecular Imaging. 11, 6, p. 448-458 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

15 Scopus citations

Structural basis for the Zn²⁺ inhibition of the zymogen-like kallikrein-related peptidase 10

Debela, M., Magdolen, V., Bode, W., Brandstetter, H. & Goettig, P., 1 Dec 2016, In: Biological Chemistry. 397, 12, p. 1251-1264 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

12 Scopus citations

The solution structure of the kallikrein-related peptidases inhibitor SPINK6

Jung, S., Fischer, J., Spudy, B., Kerkow, T., Sönnichsen, F. D., Xue, L., Bonvin, A. M. J. J., Goettig, P., Magdolen, V., Meyer-Hoffert, U. & Grötzinger, J., 26 Feb 2016, In: Biochemical and Biophysical Research Communications. 471, 1, p. 103-108 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Scopus citations

2015

Secreted uPAR isoform 2 (uPAR7b) is a novel direct target of miR-221

Falkenberg, N., Anastasov, N., Schaub, A., Radulovic, V., Schmitt, M., Magdolen, V. & Aubele, M., 2015, In: Oncotarget. 6, 10, p. 8103-8114 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

13 Scopus citations

STIM1/ORAI1-mediated Ca²⁺ influx regulates enolase-1 exteriorization

Didiasova, M., Zakrzewicz, D., Magdolen, V., Nagaraj, C., Bálint, Z., Rohde, M., Preissner, K. T. & Wygrecka, M., 8 May 2015, In: Journal of Biological Chemistry. 290, 19, p. 11983-11999 17 p.

Research output: Contribution to journal › Article › peer-review

Open Access

41 Scopus citations

The first potent diphenyl phosphonate KLK4 inhibitors with unexpected binding kinetics

Van Soom, J., Cuzzucoli Crucitti, G., Gladysz, R., Van Der Veken, P., Di Santo, R., Stuyver, I., Buck, V., Lambeir, A. M., Magdolen, V., Joossens, J. & Augustyns, K., 3 Sep 2015, In: MedChemComm. 6, 11, p. 1954-1958 5 p.

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Viktor Magdolen

Research output

Search results