Nikolai Klymiuk

2024

An Approach to Controlling Inflammation and Coagulation in Pig-to-Baboon Cardiac Xenotransplantation

Bender, M., Reichart, B., Figueiredo, C., Burgmann, J. M., Leuschen, M., Wall, F., Radan, J., Neumann, E., Mokelke, M., Buttgereit, I., Michel, S., Ellgass, R., Egerer, S., Lange, A., Baehr, A., Kessler, B., Kemter, E., Klymiuk, N., Denner, J. & Godehardt, A. W. & 11 others, Tönjes, R. R., Hagl, C., Gebauer, M., Binder, U., Skerra, A., Ayares, D., Wolf, E., Schmoeckel, M., Brenner, P., Längin, M. & Abicht, J. M., 1 Jul 2024, In: Xenotransplantation. 31, 4, e12877.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

Combination of Anti-CD40 and Anti-CD40L Antibodies as Co-Stimulation Blockade in Preclinical Cardiac Xenotransplantation

Bender, M., Abicht, J. M., Reichart, B., Neumann, E., Radan, J., Mokelke, M., Buttgereit, I., Leuschen, M., Wall, F., Michel, S., Ellgass, R., Steen, S., Paskevicius, A., Lange, A., Kessler, B., Kemter, E., Klymiuk, N., Denner, J., Godehardt, A. W. & Tönjes, R. R. & 18 others, Burgmann, J. M., Figueiredo, C., Milusev, A., Zollet, V., Salimi-Afjani, N., Despont, A., Rieben, R., Ledderose, S., Walz, C., Hagl, C., Ayares, D., Wolf, E., Schmoeckel, M., Brenner, P., Binder, U., Gebauer, M., Skerra, A. & Längin, M., Aug 2024, In: Biomedicines. 12, 8, 1927.

Research output: Contribution to journal › Article › peer-review

Open Access

Cytokine profile in peripheral blood mononuclear cells differs between embryo donor and potential recipient sows

Cambra, J. M., Gil, M. A., Cuello, C., Gonzalez-Plaza, A., Rodriguez-Martinez, H., Klymiuk, N., Martinez, E. A. & Parrilla, I., 2024, In: Frontiers in Veterinary Science. 11, 1333941.

Research output: Contribution to journal › Article › peer-review

Open Access

Hemodynamics in pig-to-baboon heterotopic thoracic cardiac xenotransplantation: Recovery from perioperative cardiac xenograft dysfunction and impairment by cardiac overgrowth

Bender, M., Panelli, A., Reichart, B., Radan, J., Mokelke, M., Neumann, E., Buttgereit, I., Michel, S., Bauer, A., Fresch, A. K., Mayr, T., Werner, F., Egerer, S., Bähr, A., Kessler, B., Klymiuk, N., Ayares, D., Wolf, E., Hagl, C. & Brenner, P. & 2 others, Längin, M. & Abicht, J. M., 1 Jan 2024, In: Xenotransplantation. 31, 1, e12841.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

Optimizing Subretinal Bleb Formation for Visual Streak Involvement in a Porcine Model for Retinal Gene Therapy

Seitz, I. P., Peters, T., Reichel, F., Bähr, A., Auch, H., Motlik, J., Ardan, T., Juhasova, J., Nemesh, Y., Juhás, S., Klymiuk, N. & Fischer, M. D., 1 Oct 2024, In: Investigative Ophthalmology and Visual Science. 65, 12, p. 41 1 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2023

Glycocalyx dynamics and the inflammatory response of genetically modified porcine endothelial cells

Milusev, A., Ren, J., Despont, A., Shaw, J., Längin, M., Bender, M., Abicht, J. M., Mokelke, M., Radan, J., Neumann, E., Kemter, E., Klymiuk, N., Ayares, D., Wolf, E., Reichart, B., Sorvillo, N. & Rieben, R., 1 Sep 2023, In: Xenotransplantation. 30, 5, e12820.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Scopus citations

Immature human engineered heart tissues engraft in a guinea pig chronic injury model

von Bibra, C., Shibamiya, A., Bähr, A., Geertz, B., Köhne, M., Stuedemann, T., Starbatty, J., der Sluis, V. H. V., Klostermeier, U. C., Hornaschewitz, N., Li, X., Wolf, E., Klymiuk, N., Krane, M., Kupatt, C., Hiebl, B., Eschenhagen, T. & Weinberger, F., May 2023, In: DMM Disease Models and Mechanisms. 16, 5, dmm049834.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Scopus citations

Phenotypic features of genetically modified DMD-X^KOX^WT pigs

Okamoto, K., Matsunari, H., Nakano, K., Umeyama, K., Hasegawa, K., Uchikura, A., Takayanagi, S., Watanabe, M., Ohgane, J., Stirm, M., Kurome, M., Klymiuk, N., Nagaya, M., Wolf, E. & Nagashima, H., Dec 2023, In: Regenerative Therapy. 24, p. 451-458 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

Proteome of airway surface liquid and mucus in newborn wildtype and cystic fibrosis piglets

Rodriguez-Piñeiro, A. M., Jaudas, F., Klymiuk, N., Bähr, A., Hansson, G. C. & Ermund, A., Dec 2023, In: Respiratory Research. 24, 1, 83.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

Systemic deletion of DMD exon 51 rescues clinically severe Duchenne muscular dystrophy in a pig model lacking DMD exon 52

Stirm, M., Shashikadze, B., Blutke, A., Kemter, E., Lange, A., Stöckl, J. B., Jaudas, F., Laane, L., Kurome, M., Keßler, B., Zakhartchenko, V., Bähr, A., Klymiuk, N., Nagashima, H., Walter, M. C., Wurst, W., Kupatt, C., Fröhlich, T. & Wolf, E., 2023, In: Proceedings of the National Academy of Sciences of the United States of America. 120, 29, e2301250120.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

Xenografts Show Signs of Concentric Hypertrophy and Dynamic Left Ventricular Outflow Tract Obstruction after Orthotopic Pig-to-baboon Heart Transplantation

Längin, M., Buttgereit, I., Reichart, B., Panelli, A., Radan, J., Mokelke, M., Neumann, E., Bender, M., Michel, S., Ellgass, R., Ying, J., Fresch, A. K., Mayr, T., Steen, S., Paskevicius, A., Egerer, S., Bähr, A., Kessler, B., Klymiuk, N. & Binder, U. & 9 others, Skerra, A., Ledderose, S., Müller, S., Walz, C., Hagl, C., Wolf, E., Ayares, D., Brenner, P. & Abicht, J. M., 1 Dec 2023, In: Transplantation. 107, 12, p. E328-E338

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

2022

Early disruption of photoreceptor cell architecture and loss of vision in a humanized pig model of usher syndromes

Grotz, S., Schäfer, J., Wunderlich, K. A., Ellederova, Z., Auch, H., Bähr, A., Runa-Vochozkova, P., Fadl, J., Arnold, V., Ardan, T., Veith, M., Santamaria, G., Dhom, G., Hitzl, W., Kessler, B., Eckardt, C., Klein, J., Brymova, A., Linnert, J. & Kurome, M. & 20 others, Zakharchenko, V., Fischer, A., Blutke, A., Döring, A., Suchankova, S., Popelar, J., Rodríguez-Bocanegra, E., Dlugaiczyk, J., Straka, H., May-Simera, H., Wang, W., Laugwitz, K. L., Vandenberghe, L. H., Wolf, E., Nagel-Wolfrum, K., Peters, T., Motlik, J., Fischer, M. D., Wolfrum, U. & Klymiuk, N., 7 Apr 2022, In: EMBO Molecular Medicine. 14, 4, e14817.

Research output: Contribution to journal › Article › peer-review

Open Access

15 Scopus citations

Evolutionarily conserved properties of CLCA proteins 1, 3 and 4, as revealed by phylogenetic and biochemical studies in avian homologues

Bartenschlager, F., Klymiuk, N., Weise, C., Kuropka, B., Gruber, A. D. & Mundhenk, L., Apr 2022, In: PLoS ONE. 17, 4 April, e0266937.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

Genomic, biochemical and expressional properties reveal strong conservation of the CLCA2 gene in birds and mammals

Bartenschlager, F., Klymiuk, N., Gruber, A. D. & Mundhenk, L., Nov 2022, In: PeerJ. 10, e14202.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

Migratory and anti-fibrotic programmes define the regenerative potential of human cardiac progenitors

Poch, C. M., Foo, K. S., De Angelis, M. T., Jennbacken, K., Santamaria, G., Bähr, A., Wang, Q. D., Reiter, F., Hornaschewitz, N., Zawada, D., Bozoglu, T., My, I., Meier, A., Dorn, T., Hege, S., Lehtinen, M. L., Tsoi, Y. L., Hovdal, D., Hyllner, J. & Schwarz, S. & 24 others, Sudhop, S., Jurisch, V., Sini, M., Fellows, M. D., Cummings, M., Clarke, J., Baptista, R., Eroglu, E., Wolf, E., Klymiuk, N., Lu, K., Tomasi, R., Dendorfer, A., Gaspari, M., Parrotta, E., Cuda, G., Krane, M., Sinnecker, D., Hoppmann, P., Kupatt, C., Fritsche-Danielson, R., Moretti, A., Chien, K. R. & Laugwitz, K. L., May 2022, In: Nature Cell Biology. 24, 5, p. 659-671 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

26 Scopus citations

TLR5 signalling is hyper-responsive in porcine cystic fibrosis airways epithelium

Fleurot, I., López-Gálvez, R., Barbry, P., Guillon, A., Si-Tahar, M., Bähr, A., Klymiuk, N., Sirard, J. C. & Caballero, I., Mar 2022, In: Journal of Cystic Fibrosis. 21, 2, p. e117-e121

Research output: Contribution to journal › Article › peer-review

Open Access

5 Scopus citations

2021

Airway administration of flagellin regulates the inflammatory response to pseudomonas aeruginosa

Lopez-Galvez, R., Fleurot, I., Chamero, P., Trapp, S., Olivier, M., Chevaleyre, C., Barc, C., Riou, M., Rossignol, C., Guillon, A., Si-Tahar, M., May, T., Barbry, P., Bahr, A., Klymiuk, N., Sirard, J. C. & Caballero, I., Oct 2021, In: American Journal of Respiratory Cell and Molecular Biology. 65, 4, p. 378-389 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

9 Scopus citations

A scalable, clinically severe pig model for Duchenne muscular dystrophy

Stirm, M., Fonteyne, L. M., Shashikadze, B., Lindner, M., Chirivi, M., Lange, A., Kaufhold, C., Mayer, C., Medugorac, I., Kessler, B., Kurome, M., Zakhartchenko, V., Hinrichs, A., Kemter, E., Krause, S., Wanke, R., Arnold, G. J., Wess, G., Nagashima, H. & de Angelis, M. H. & 15 others, Flenkenthaler, F., Kobelke, L. A., Bearzi, C., Rizzi, R., Bähr, A., Reese, S., Matiasek, K., Walter, M. C., Kupatt, C., Ziegler, S., Bartenstein, P., Fröhlich, T., Klymiuk, N., Blutke, A. & Wolf, E., Dec 2021, In: DMM Disease Models and Mechanisms. 14, 12, dmm049285.

Research output: Contribution to journal › Article › peer-review

Open Access

25 Scopus citations

CFTR Correctors and Antioxidants Partially Normalize Lipid Imbalance but not Abnormal Basal Inflammatory Cytokine Profile in CF Bronchial Epithelial Cells

Veltman, M., De Sanctis, J. B., Stolarczyk, M., Klymiuk, N., Bähr, A., Brouwer, R. W., Oole, E., Shah, J., Ozdian, T., Liao, J., Martini, C., Radzioch, D., Hanrahan, J. W. & Scholte, B. J., 4 Feb 2021, In: Frontiers in Physiology. 12, 619442.

Research output: Contribution to journal › Article › peer-review

Open Access

30 Scopus citations

Cold non-ischemic heart preservation with continuous perfusion prevents early graft failure in orthotopic pig-to-baboon xenotransplantation

Längin, M., Reichart, B., Steen, S., Sjöberg, T., Paskevicius, A., Liao, Q., Qin, G., Mokelke, M., Mayr, T., Radan, J., Issl, L., Buttgereit, I., Ying, J., Fresch, A. K., Panelli, A., Egerer, S., Bähr, A., Kessler, B., Milusev, A. & Sfriso, R. & 9 others, Rieben, R., Ayares, D., Murray, P. J., Ellgass, R., Walz, C., Klymiuk, N., Wolf, E., Abicht, J. M. & Brenner, P., 1 Jan 2021, In: Xenotransplantation. 28, 1, e12636.

Research output: Contribution to journal › Article › peer-review

Open Access

42 Scopus citations

Evidence of early increased sialylation of airway mucins and defective mucociliary clearance in CFTR-deficient piglets

Caballero, I., Ringot-Destrez, B., Si-Tahar, M., Barbry, P., Guillon, A., Lantier, I., Berri, M., Chevaleyre, C., Fleurot, I., Barc, C., Ramphal, R., Pons, N., Paquet, A., Lebrigand, K., Baron, C., Bähr, A., Klymiuk, N., Léonard, R. & Robbe-Masselot, C., Jan 2021, In: Journal of Cystic Fibrosis. 20, 1, p. 173-182 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

14 Scopus citations

Growth hormone receptor knockout to reduce the size of donor pigs for preclinical xenotransplantation studies

Hinrichs, A., Riedel, E. O., Klymiuk, N., Blutke, A., Kemter, E., Längin, M., Dahlhoff, M., Keßler, B., Kurome, M., Zakhartchenko, V., Jemiller, E. M., Ayares, D., Bidlingmaier, M., Flenkenthaler, F., Hrabĕ de Angelis, M., Arnold, G. J., Reichart, B., Fröhlich, T. & Wolf, E., 1 Mar 2021, In: Xenotransplantation. 28, 2, e12664.

Research output: Contribution to journal › Article › peer-review

Open Access

42 Scopus citations

Human Engineered Heart Tissue Patches Remuscularize the Injured Heart in a Dose-Dependent Manner

Querdel, E., Reinsch, M., Castro, L., Köse, D., Bähr, A., Reich, S., Geertz, B., Ulmer, B., Schulze, M., Lemoine, M. D., Krause, T., Lemme, M., Sani, J., Shibamiya, A., Stüdemann, T., Köhne, M., Bibra, C. V., Hornaschewitz, N., Pecha, S. & Nejahsie, Y. & 9 others, Mannhardt, I., Christ, T., Reichenspurner, H., Hansen, A., Klymiuk, N., Krane, M., Kupatt, C., Eschenhagen, T. & Weinberger, F., 18 May 2021, In: Circulation. 143, 20, p. 1991-2006 16 p.

Research output: Contribution to journal › Article › peer-review

Open Access

76 Scopus citations

Mucus threads from surface goblet cells clear particles from the airways

Ermund, A., Meiss, L. N., Dolan, B., Jaudas, F., Ewaldsson, L., Bähr, A., Klymiuk, N. & Hansson, G. C., Dec 2021, In: Respiratory Research. 22, 1, 303.

Research output: Contribution to journal › Article › peer-review

Open Access

11 Scopus citations

New generation ENaC inhibitors detach cystic fibrosis airway mucus bundles via sodium/hydrogen exchanger inhibition

Giorgetti, M., Klymiuk, N., Bähr, A., Hemmerling, M., Jinton, L., Tarran, R., Malmgren, A., Åstrand, A., Hansson, G. C. & Ermund, A., 5 Aug 2021, In: European Journal of Pharmacology. 904, 174123.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Scopus citations

Sequential in vivo labeling of insulin secretory granule pools in INS-SNAP transgenic pigs

Kemter, E., Müller, A., Neukam, M., Ivanova, A., Klymiuk, N., Renner, S., Yang, K., Broichhagen, J., Kurome, M., Zakhartchenko, V., Kessler, B., Knoch, K. P., Bickle, M., Ludwig, B., Johnsson, K., Lickert, H., Kurth, T., Wolf, E. & Solimena, M., 14 Sep 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 37, e2107665118.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Scopus citations

2020

A decade of experience with genetically tailored pig models for diabetes and metabolic research

Zettler, S., Renner, S., Kemter, E., Hinrichs, A., Klymiuk, N., Backman, M., Riedel, E. O., Mueller, C., Streckel, E., Braun-Reichhart, C., Martins, A. S., Kurome, M., Keßler, B., Zakhartchenko, V., Flenkenthaler, F., Arnold, G. J., Fröhlich, T., Blum, H., Blutke, A. & Wanke, R. & 1 others, Wolf, E., 2020, In: Animal Reproduction. 17, 3, e20200064.

Research output: Contribution to journal › Article › peer-review

Open Access

13 Scopus citations

CFTR-deficient pigs display alterations of bone microarchitecture and composition at birth

Braux, J., Jourdain, M. L., Guillaume, C., Untereiner, V., Piot, O., Baehr, A., Klymiuk, N., Winter, N., Berri, M., Buzoni-Gatel, D., Caballero, I., Guillon, A., Si-Tahar, M., Jacquot, J. & Velard, F., May 2020, In: Journal of Cystic Fibrosis. 19, 3, p. 466-475 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

7 Scopus citations

Expression of human thrombomodulin on porcine endothelial cells can reduce platelet aggregation but did not reduce activation of complement or endothelium – an experimental study

Ramackers, W., Rataj, D., Werwitzke, S., Bergmann, S., Winkler, M., Wünsch, A., Bähr, A., Wolf, E., Klymiuk, N., Ayares, D. & Tiede, A., 1 Apr 2020, In: Transplant International. 33, 4, p. 437-449 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Scopus citations

Genetically encoded Ca²⁺-sensor reveals details of porcine endothelial cell activation upon contact with human serum

Wuensch, A., Kameritsch, P., Sfriso, R., Jemiller, E. M., Bähr, A., Kurome, M., Kessler, B., Kemter, E., Kupatt, C., Reichart, B., Rieben, R., Wolf, E. & Klymiuk, N., 1 Sep 2020, In: Xenotransplantation. 27, 5, e12585.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

Intrinsic alterations in peripheral neutrophils from cystic fibrosis newborn piglets

Bréa, D., Soler, L., Fleurot, I., Melo, S., Chevaleyre, C., Berri, M., Labas, V., Teixeira-Gomes, A. P., Pujo, J., Cenac, N., Bähr, A., Klymiuk, N., Guillon, A., Si-Tahar, M. & Caballero, I., Sep 2020, In: Journal of Cystic Fibrosis. 19, 5, p. 830-836 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Scopus citations

Linkage between growth retardation and pituitary cell morphology in a dystrophin-deficient pig model of Duchenne muscular dystrophy

Hofmann, I., Kemter, E., Theobalt, N., Fiedler, S., Bidlingmaier, M., Hinrichs, A., Aichler, M., Burkhardt, K., Klymiuk, N., Wolf, E., Wanke, R. & Blutke, A., Apr 2020, In: Growth Hormone and IGF Research. 51, p. 6-16 11 p.

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Pig-to-non-human primate heart transplantation: The final step toward clinical xenotransplantation?

Reichart, B., Längin, M., Radan, J., Mokelke, M., Buttgereit, I., Ying, J., Fresch, A. K., Mayr, T., Issl, L., Buchholz, S., Michel, S., Ellgass, R., Mihalj, M., Egerer, S., Baehr, A., Kessler, B., Kemter, E., Kurome, M., Zakhartchenko, V. & Steen, S. & 20 others, Sjöberg, T., Paskevicius, A., Krüger, L., Fiebig, U., Denner, J., Godehardt, A. W., Tönjes, R. R., Milusev, A., Rieben, R., Sfriso, R., Walz, C., Kirchner, T., Ayares, D., Lampe, K., Schönmann, U., Hagl, C., Wolf, E., Klymiuk, N., Abicht, J. M. & Brenner, P., Aug 2020, In: Journal of Heart and Lung Transplantation. 39, 8, p. 751-757 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

66 Scopus citations

Progressive Proteome Changes in the Myocardium of a Pig Model for Duchenne Muscular Dystrophy

Tamiyakul, H., Kemter, E., Kösters, M., Ebner, S., Blutke, A., Klymiuk, N., Flenkenthaler, F., Wolf, E., Arnold, G. J. & Fröhlich, T., 25 Sep 2020, In: iScience. 23, 9, 101516.

Research output: Contribution to journal › Article › peer-review

Open Access

17 Scopus citations

2019

Detection of collagens by multispectral optoacoustic tomography as an imaging biomarker for Duchenne muscular dystrophy

Regensburger, A. P., Fonteyne, L. M., Jüngert, J., Wagner, A. L., Gerhalter, T., Nagel, A. M., Heiss, R., Flenkenthaler, F., Qurashi, M., Neurath, M. F., Klymiuk, N., Kemter, E., Fröhlich, T., Uder, M., Woelfle, J., Rascher, W., Trollmann, R., Wolf, E., Waldner, M. J. & Knieling, F., 1 Dec 2019, In: Nature Medicine. 25, 12, p. 1905-1915 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

139 Scopus citations

Genetically modified pigs as donors of cells, tissues, and organs for xenotransplantation

Wolf, E., Kemter, E., Klymiuk, N. & Reichart, B., 25 Jun 2019, In: Animal Frontiers. 9, 3, p. 13-20 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

41 Scopus citations

Mild maternal hyperglycemia in INS^C93S transgenic pigs causes impaired glucose tolerance and metabolic alterations in neonatal offspring

Renner, S., Martins, A. S., Streckel, E., Braun-Reichhart, C., Backman, M., Prehn, C., Klymiuk, N., Bähr, A., Blutke, A., Landbrecht-Schessl, C., Wünsch, A., Kessler, B., Kurome, M., Hinrichs, A., Koopmans, S. J., Krebs, S., Kemter, E., Rathkolb, B., Nagashima, H. & Blum, H. & 6 others, Ritzmann, M., Wanke, R., Aigner, B., Adamski, J., De Angelis, M. H. & Wolf, E., 2019, In: DMM Disease Models and Mechanisms. 12, 8, dmm039156.

Research output: Contribution to journal › Article › peer-review

Open Access

12 Scopus citations

Targeting αgal epitopes for multi-species embryo immunosurgery

Kurome, M., Baehr, A., Simmet, K., Jemiller, E. M., Egerer, S., Dahlhoff, M., Zakhartchenko, V., Nagashima, H., Klymiuk, N., Kessler, B. & Wolf, E., 2019, In: Reproduction, Fertility and Development. 31, 4, p. 820-826 7 p.

Research output: Contribution to journal › Article › peer-review

2018

Consistent success in life-supporting porcine cardiac xenotransplantation

Längin, M., Mayr, T., Reichart, B., Michel, S., Buchholz, S., Guethoff, S., Dashkevich, A., Baehr, A., Egerer, S., Bauer, A., Mihalj, M., Panelli, A., Issl, L., Ying, J., Fresch, A. K., Buttgereit, I., Mokelke, M., Radan, J., Werner, F. & Lutzmann, I. & 28 others, Steen, S., Sjöberg, T., Paskevicius, A., Qiuming, L., Sfriso, R., Rieben, R., Dahlhoff, M., Kessler, B., Kemter, E., Klett, K., Hinkel, R., Kupatt, C., Falkenau, A., Reu, S., Ellgass, R., Herzog, R., Binder, U., Wich, G., Skerra, A., Ayares, D., Kind, A., Schönmann, U., Kaup, F. J., Hagl, C., Wolf, E., Klymiuk, N., Brenner, P. & Abicht, J. M., 20 Dec 2018, In: Nature. 564, 7736, p. 430-433 4 p.

Research output: Contribution to journal › Article › peer-review

368 Scopus citations

Early weaning completely eliminates porcine cytomegalovirus from a newly established pig donor facility for xenotransplantation

Egerer, S., Fiebig, U., Kessler, B., Zakhartchenko, V., Kurome, M., Reichart, B., Kupatt, C., Klymiuk, N., Wolf, E., Denner, J. & Bähr, A., 1 Jul 2018, In: Xenotransplantation. 25, 4, e12449.

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Granule-stored MUC5B mucins are packed by the noncovalent formation of N-terminal head-to-head tetramers

Trillo-Muyo, S., Nilsson, H. E., Recktenwald, C. V., Ermund, A., Ridley, C., Meiss, L. N., Bähr, A., Klymiuk, N., Wine, J. J., Koeck, P. J. B., Thornton, D. J., Hebert, H. & Hansson, G. C., 13 Apr 2018, In: Journal of Biological Chemistry. 293, 15, p. 5746-5754 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

50 Scopus citations

Interspecies diversity of chloride channel regulators, calcium-activated 3 genes

Mundhenk, L., Erickson, N. A., Klymiuk, N. & Gruber, A. D., Jan 2018, In: PLoS ONE. 13, 1, e0191512.

Research output: Contribution to journal › Article › peer-review

Open Access

11 Scopus citations

Modeling lethal X-linked genetic disorders in pigs with ensured fertility

Matsunari, H., Watanabe, M., Nakano, K., Enosawa, S., Umeyama, K., Uchikura, A., Yashima, S., Fukuda, T., Klymiuk, N., Kurome, M., Kessler, B., Wuensch, A., Zakhartchenko, V., Wolf, E., Hanazono, Y., Nagaya, M., Umezawa, A., Nakauchi, H. & Nagashima, H., 23 Jan 2018, In: Proceedings of the National Academy of Sciences of the United States of America. 115, 4, p. 708-713 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

23 Scopus citations

Multiple genetically modified GTKO/hCD46/HLA-E/hβ2−mg porcine hearts are protected from complement activation and natural killer cell infiltration during ex vivo perfusion with human blood

Abicht, J. M., Sfriso, R., Reichart, B., Längin, M., Gahle, K., Puga Yung, G. L., Seebach, J. D., Rieben, R., Ayares, D., Wolf, E., Klymiuk, N., Baehr, A., Kind, A., Mayr, T. & Bauer, A., 1 Sep 2018, In: Xenotransplantation. 25, 5, e12390.

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

OCT4/POU5F1 is required for NANOG expression in bovine blastocysts

Simmet, K., Zakhartchenko, V., Philippou-Massier, J., Blum, H., Klymiuk, N. & Wolf, E., 2018, In: Proceedings of the National Academy of Sciences of the United States of America. 115, 11, p. 2770-2775 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

90 Scopus citations

Release of pig leukocytes and reduced human NK cell recruitment during ex vivo perfusion of HLA-E/human CD46 double-transgenic pig limbs with human blood

Puga Yung, G., Bongoni, A. K., Pradier, A., Madelon, N., Papaserafeim, M., Sfriso, R., Ayares, D. L., Wolf, E., Klymiuk, N., Bähr, A., Constantinescu, M. A., Voegelin, E., Kiermeir, D., Jenni, H., Rieben, R. & Seebach, J. D., 1 Jan 2018, In: Xenotransplantation. 25, 1, e12357.

Research output: Contribution to journal › Article › peer-review

Open Access

17 Scopus citations

Remapping of the belted phenotype in cattle on BTA3 identifies a multiplication event as the candidate causal mutation

Rothammer, S., Kunz, E., Krebs, S., Bitzer, F., Hauser, A., Zinovieva, N., Klymiuk, N. & Medugorac, I., 6 Jul 2018, In: Genetics Selection Evolution. 50, 1, 36.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Scopus citations

The mucus bundles responsible for airway cleaning are retained in cystic fibrosis and by cholinergic stimulation

Ermund, A., Meiss, L. N., Dolan, B., Bähr, A., Klymiuk, N. & Hansson, G. C., 2018, In: European Respiratory Journal. 52, 2, 1800457.

Research output: Contribution to journal › Article › peer-review

Open Access

40 Scopus citations

2017

Assessment of the anticoagulant and anti-inflammatory properties of endothelial cells using 3D cell culture and non-anticoagulated whole blood

Sfriso, R., Bongoni, A., Banz, Y., Klymiuk, N., Wolf, E. & Rieben, R., 5 Sep 2017, In: Journal of Visualized Experiments. 2017, 127, e56227.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Scopus citations

Direct introduction of gene constructs into the pronucleus-like structure of cloned embryos: a new strategy for the generation of genetically modified pigs

Kurome, M., Leuchs, S., Kessler, B., Kemter, E., Jemiller, E. M., Foerster, B., Klymiuk, N., Zakhartchenko, V. & Wolf, E., 1 Apr 2017, In: Transgenic Research. 26, 2, p. 309-318 10 p.

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Nikolai Klymiuk

Research output

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