Dietmar Zehn

2025

A distinct priming phase regulates CD8 T cell immunity by orchestrating paracrine IL-2 signals

Jobin, K., Seetharama, D., Rüttger, L., Fenton, C., Kharybina, E., Wirsching, A., Huang, A., Knöpper, K., Kaisho, T., Busch, D. H., Vaeth, M., Saliba, A. E., Graw, F., Pulfer, A., González, S. F., Zehn, D., Liang, Y., Ugur, M., Gasteiger, G. & Kastenmüller, W., 11 Apr 2025, In: Science. 388, 6743, p. eadq1405

Research output: Contribution to journal › Article › peer-review

A specific microbial consortium enhances Th1 immunity, improves LCMV viral clearance but aggravates LCMV disease pathology in mice

Kolland, D., Kuhlmann, M., de Almeida, G. P., Köhler, A., Arifovic, A., von Strempel, A., Pourjam, M., Bolsega, S., Wurmser, C., Steiger, K., Basic, M., Neuhaus, K., Schmidt-Weber, C. B., Stecher, B., Zehn, D. & Ohnmacht, C., Dec 2025, In: Nature Communications. 16, 1, 3902.

Research output: Contribution to journal › Article › peer-review

Open Access

ImmunOctoberfest reloaded

Schulz, A. M., Zebley, C. C., Youngblood, B. & Zehn, D., Feb 2025, In: Nature Immunology. 26, 2, p. 165-167 3 p., 4418.

Research output: Contribution to journal › Article › peer-review

Precursors of exhausted T cells are pre-emptively formed in acute infection

Chu, T., Wu, M., Hoellbacher, B., de Almeida, G. P., Wurmser, C., Berner, J., Donhauser, L. V., Gerullis, A. K., Lin, S., Cepeda-Mayorga, J. D., Kilb, I. I., Bongers, L., Toppeta, F., Strobl, P., Youngblood, B., Schulz, A. M., Zippelius, A., Knolle, P. A., Heinig, M. & Hackstein, C. P. & 1 others, Zehn, D., 17 Apr 2025, In: Nature. 640, 8059, p. 782-792 11 p., 5577.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Scopus citations

2024

A liver immune rheostat regulates CD8 T cell immunity in chronic HBV infection

Bosch, M., Kallin, N., Donakonda, S., Zhang, J. D., Wintersteller, H., Hegenbarth, S., Heim, K., Ramirez, C., Fürst, A., Lattouf, E. I., Feuerherd, M., Chattopadhyay, S., Kumpesa, N., Griesser, V., Hoflack, J. C., Siebourg-Polster, J., Mogler, C., Swadling, L., Pallett, L. J. & Meiser, P. & 36 others, Manske, K., de Almeida, G. P., Kosinska, A. D., Sandu, I., Schneider, A., Steinbacher, V., Teng, Y., Schnabel, J., Theis, F., Gehring, A. J., Boonstra, A., Janssen, H. L. A., Vandenbosch, M., Cuypers, E., Öllinger, R., Engleitner, T., Rad, R., Steiger, K., Oxenius, A., Lo, W. L., Klepsch, V., Baier, G., Holzmann, B., Maini, M. K., Heeren, R., Murray, P. J., Thimme, R., Herrmann, C., Protzer, U., Böttcher, J. P., Zehn, D., Wohlleber, D., Lauer, G. M., Hofmann, M., Luangsay, S. & Knolle, P. A., 25 Jul 2024, In: Nature. 631, 8022, p. 867-875 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

18 Scopus citations

Antitumor progenitor exhausted CD8⁺ T cells are sustained by TCR engagement

Lan, X., Mi, T., Alli, S., Guy, C., Djekidel, M. N., Liu, X., Boi, S., Chowdhury, P., He, M., Zehn, D., Feng, Y. & Youngblood, B., Jun 2024, In: Nature Immunology. 25, 6, p. 1046-1058 13 p.

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Dynamic landscapes and protective immunity coordinated by influenza-specific lung-resident memory CD8⁺ T cells revealed by intravital imaging

van de Wall, S., Anthony, S. M., Hancox, L. S., Pewe, L. L., Langlois, R. A., Zehn, D., Badovinac, V. P. & Harty, J. T., 13 Aug 2024, In: Immunity. 57, 8, p. 1878-1892.e5

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

PGE₂ limits effector expansion of tumour-infiltrating stem-like CD8⁺ T cells

Lacher, S. B., Dörr, J., de Almeida, G. P., Hönninger, J., Bayerl, F., Hirschberger, A., Pedde, A. M., Meiser, P., Ramsauer, L., Rudolph, T. J., Spranger, N., Morotti, M., Grimm, A. J., Jarosch, S., Oner, A., Gregor, L., Lesch, S., Michaelides, S., Fertig, L. & Briukhovetska, D. & 9 others, Majed, L., Stock, S., Busch, D. H., Buchholz, V. R., Knolle, P. A., Zehn, D., Dangaj Laniti, D., Kobold, S. & Böttcher, J. P., 9 May 2024, In: Nature. 629, 8011, p. 417-425 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

50 Scopus citations

2023

An adrenaline kick to exhaust T cells

Berner, J. & Zehn, D., Nov 2023, In: Nature Immunology. 24, 11, p. 1792-1793 2 p.

Research output: Contribution to journal › Article › peer-review

A single-amino acid substitution in the adaptor LAT accelerates TCR proofreading kinetics and alters T-cell selection, maintenance and function

Lo, W. L., Kuhlmann, M., Rizzuto, G., Ekiz, H. A., Kolawole, E. M., Revelo, M. P., Andargachew, R., Li, Z., Tsai, Y. L., Marson, A., Evavold, B. D., Zehn, D. & Weiss, A., Apr 2023, In: Nature Immunology. 24, 4, p. 676-689 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

14 Scopus citations

Functional T cells are capable of supernumerary cell division and longevity

Soerens, A. G., Künzli, M., Quarnstrom, C. F., Scott, M. C., Swanson, L., Locquiao, J., Ghoneim, H. E., Zehn, D., Youngblood, B., Vezys, V. & Masopust, D., 23 Feb 2023, In: Nature. 614, 7949, p. 762-766 5 p.

Research output: Contribution to journal › Article › peer-review

102 Scopus citations

Pyrimidine de novo synthesis inhibition selectively blocks effector but not memory T cell development

Scherer, S., Oberle, S. G., Kanev, K., Gerullis, A. K., Wu, M., de Almeida, G. P., Puleston, D. J., Baixauli, F., Aly, L., Greco, A., Nizharadze, T., Becker, N. B., Hoesslin, M. V., Donhauser, L. V., Berner, J., Chu, T., McNamara, H. A., Esencan, Z., Roelli, P. & Wurmser, C. & 13 others, Kleiter, I., Vehreschild, M. J. G. T., Mayer, C. A., Knolle, P., Klingenspor, M., Fumagalli, V., Iannacone, M., Prlic, M., Korn, T., Pearce, E. L., Höfer, T., Schulz, A. M. & Zehn, D., Mar 2023, In: Nature Immunology. 24, 3, p. 501-515 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

13 Scopus citations

Responses of patients with cancer to mRNA vaccines depend on the time interval between vaccination and last treatment

Donhauser, L. V., Veloso De Oliveira, J., Schick, C., Manlik, W., Styblova, S., Lutzenberger, S., Aigner, M., Philipp, P., Robert, S., Gandorfer, B., Hempel, D., Hempel, L. & Zehn, D., 19 Sep 2023, In: Journal for ImmunoTherapy of Cancer. 11, 9, e007387.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Scopus citations

The alarmin interleukin-33 promotes the expansion and preserves the stemness of Tcf-1⁺ CD8⁺ T cells in chronic viral infection

Marx, A. F., Kallert, S. M., Brunner, T. M., Villegas, J. A., Geier, F., Fixemer, J., Abreu-Mota, T., Reuther, P., Bonilla, W. V., Fadejeva, J., Kreutzfeldt, M., Wagner, I., Aparicio-Domingo, P., Scarpellino, L., Charmoy, M., Utzschneider, D. T., Hagedorn, C., Lu, M., Cornille, K. & Stauffer, K. & 7 others, Kreppel, F., Merkler, D., Zehn, D., Held, W., Luther, S. A., Löhning, M. & Pinschewer, D. D., 11 Apr 2023, In: Immunity. 56, 4, p. 813-828.e10

Research output: Contribution to journal › Article › peer-review

Open Access

27 Scopus citations

2022

Dynamics of spike-and nucleocapsid specific immunity during long-term follow-up and vaccination of SARS-CoV-2 convalescents

Koerber, N., Priller, A., Yazici, S., Bauer, T., Cheng, C. C., Mijočević, H., Wintersteller, H., Jeske, S., Vogel, E., Feuerherd, M., Tinnefeld, K., Winter, C., Ruland, J., Gerhard, M., Haller, B., Christa, C., Zelger, O., Roggendorf, H., Halle, M. & Erber, J. & 5 others, Lingor, P., Keppler, O., Zehn, D., Protzer, U. & Knolle, P. A., Dec 2022, In: Nature Communications. 13, 1, 153.

Research output: Contribution to journal › Article › peer-review

Open Access

49 Scopus citations

MYB orchestrates T cell exhaustion and response to checkpoint inhibition

Tsui, C., Kretschmer, L., Rapelius, S., Gabriel, S. S., Chisanga, D., Knöpper, K., Utzschneider, D. T., Nüssing, S., Liao, Y., Mason, T., Torres, S. V., Wilcox, S. A., Kanev, K., Jarosch, S., Leube, J., Nutt, S. L., Zehn, D., Parish, I. A., Kastenmüller, W. & Shi, W. & 2 others, Buchholz, V. R. & Kallies, A., 8 Sep 2022, In: Nature. 609, 7926, p. 354-360 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

129 Scopus citations

Secondary infections rejuvenate the intestinal CD103⁺ tissue-resident memory T cell pool

von Hoesslin, M., Kuhlmann, M., de Almeida, G. P., Kanev, K., Wurmser, C., Gerullis, A. K., Roelli, P., Berner, J. & Zehn, D., Nov 2022, In: Science Immunology. 7, 77, eabp9553.

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

T cell receptor and IL-2 signaling strength control memory CD8⁺ T cell functional fitness via chromatin remodeling

Chin, S. S., Guillen, E., Chorro, L., Achar, S., Ng, K., Oberle, S., Alfei, F., Zehn, D., Altan-Bonnet, G., Delahaye, F. & Lauvau, G., Dec 2022, In: Nature Communications. 13, 1, 2240.

Research output: Contribution to journal › Article › peer-review

Open Access

29 Scopus citations

Type 1 conventional dendritic cells maintain and guide the differentiation of precursors of exhausted T cells in distinct cellular niches

Dähling, S., Mansilla, A. M., Knöpper, K., Grafen, A., Utzschneider, D. T., Ugur, M., Whitney, P. G., Bachem, A., Arampatzi, P., Imdahl, F., Kaisho, T., Zehn, D., Klauschen, F., Garbi, N., Kallies, A., Saliba, A. E., Gasteiger, G., Bedoui, S. & Kastenmüller, W., 12 Apr 2022, In: Immunity. 55, 4, p. 656-670.e8

Research output: Contribution to journal › Article › peer-review

Open Access

65 Scopus citations

2021

Auto-aggressive CXCR6⁺ CD8 T cells cause liver immune pathology in NASH

Dudek, M., Pfister, D., Donakonda, S., Filpe, P., Schneider, A., Laschinger, M., Hartmann, D., Hüser, N., Meiser, P., Bayerl, F., Inverso, D., Wigger, J., Sebode, M., Öllinger, R., Rad, R., Hegenbarth, S., Anton, M., Guillot, A., Bowman, A. & Heide, D. & 28 others, Müller, F., Ramadori, P., Leone, V., Garcia-Caceres, C., Gruber, T., Seifert, G., Kabat, A. M., Malm, J. P., Reider, S., Effenberger, M., Roth, S., Billeter, A. T., Müller-Stich, B., Pearce, E. J., Koch-Nolte, F., Käser, R., Tilg, H., Thimme, R., Böttler, T., Tacke, F., Dufour, J. F., Haller, D., Murray, P. J., Heeren, R., Zehn, D., Böttcher, J. P., Heikenwälder, M. & Knolle, P. A., 15 Apr 2021, In: Nature. 592, 7854, p. 444-449 6 p.

Research output: Contribution to journal › Article › peer-review

318 Scopus citations

Cervicovaginal tissue residence confers a distinct differentiation program upon memory CD8 T cells

Davé, V. A., Cardozo-Ojeda, E. F., Mair, F., Erickson, J., Woodward-Davis, A. S., Koehne, A., Soerens, A., Czartoski, J., Teague, C., Potchen, N., Oberle, S., Zehn, D., Schiffer, J. T., Lund, J. M. & Prlic, M., 15 Jun 2021, In: Journal of Immunology. 206, 12, p. 2937-2948 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

10 Scopus citations

Enabling single-cell trajectory network enrichment

Grønning, A. G. B., Oubounyt, M., Kanev, K., Lund, J., Kacprowski, T., Zehn, D., Röttger, R. & Baumbach, J., Feb 2021, In: Nature Computational Science. 1, 2, p. 153-163 11 p.

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Inflammatory signals are sufficient to elicit TOX expression in mouse and human CD8⁺ T cells

Maurice, N. J., Berner, J., Taber, A. K., Zehn, D. & Prlic, M., 8 Jul 2021, In: JCI Insight. 6, 13, e150744.

Research output: Contribution to journal › Article › peer-review

Open Access

25 Scopus citations

Loss of the orphan nuclear receptor NR2F6 enhances CD8⁺ T-cell memory via IFN-γ

Jakic, B., Olson, W. J., Siegmund, K., Klepsch, V., Kimpel, J., Labi, V., Zehn, D., Baier, G. & Hermann-Kleiter, N., Feb 2021, In: Cell Death and Disease. 12, 2, 187.

Research output: Contribution to journal › Article › peer-review

Open Access

17 Scopus citations

Siglec-H-Deficient Mice Show Enhanced Type I IFN Responses, but Do Not Develop Autoimmunity After Influenza or LCMV Infections

Szumilas, N., Corneth, O. B. J., Lehmann, C. H. K., Schmitt, H., Cunz, S., Cullen, J. G., Chu, T., Marosan, A., Mócsai, A., Benes, V., Zehn, D., Dudziak, D., Hendriks, R. W. & Nitschke, L., 23 Aug 2021, In: Frontiers in Immunology. 12, 698420.

Research output: Contribution to journal › Article › peer-review

Open Access

9 Scopus citations

Tailoring the resolution of single-cell RNA sequencing for primary cytotoxic T cells

Kanev, K., Roelli, P., Wu, M., Wurmser, C., Delorenzi, M., Pfaffl, M. W. & Zehn, D., 1 Dec 2021, In: Nature Communications. 12, 1, 569.

Research output: Contribution to journal › Article › peer-review

Open Access

7 Scopus citations

The role of exhaustion in CAR T cell therapy

Delgoffe, G. M., Xu, C., Mackall, C. L., Green, M. R., Gottschalk, S., Speiser, D. E., Zehn, D. & Beavis, P. A., 12 Jul 2021, In: Cancer Cell. 39, 7, p. 885-888 4 p.

Research output: Contribution to journal › Article › peer-review

Open Access

60 Scopus citations

TOX defines the degree of CD8+ T cell dysfunction in distinct phases of chronic HBV infection

Heim, K., Binder, B., Sagar, Wieland, D., Hensel, N., Llewellyn-Lacey, S., Gostick, E., Price, D. A., Emmerich, F., Vingerhoet, H., Kraft, A. R. M., Cornberg, M., Boettler, T., Neumann-Haefelin, C., Zehn, D., Bengsch, B., Hofmann, M. & Thimme, R., 1 Aug 2021, In: Gut. 70, 8, p. 1550-1560 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

54 Scopus citations

2020

Beta cell-specific CD8⁺ T cells maintain stem cell memory-associated epigenetic programs during type 1 diabetes

Abdelsamed, H. A., Zebley, C. C., Nguyen, H., Rutishauser, R. L., Fan, Y., Ghoneim, H. E., Crawford, J. C., Alfei, F., Alli, S., Ribeiro, S. P., Castellaw, A. H., McGargill, M. A., Jin, H., Boi, S. K., Speake, C., Serti, E., Turka, L. A., Busch, M. E., Stone, M. & Deeks, S. G. & 5 others, Sekaly, R. P., Zehn, D., James, E. A., Nepom, G. T. & Youngblood, B., 1 May 2020, In: Nature Immunology. 21, 5, p. 578-587 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

79 Scopus citations

Cell-intrinsic adrenergic signaling controls the adaptive NK cell response to viral infection

Diaz-Salazar, C., Bou-Puerto, R., Mujal, A. M., Lau, C. M., Hoesslin, M. V., Zehn, D. & Sun, J. C., 2020, In: Journal of Experimental Medicine. 217, 4, e20190549.

Research output: Contribution to journal › Article › peer-review

Open Access

46 Scopus citations

Dynamics of the Coreceptor-LCK Interactions during T Cell Development Shape the Self-Reactivity of Peripheral CD4 and CD8 T Cells

Horkova, V., Drobek, A., Mueller, D., Gubser, C., Niederlova, V., Wyss, L., King, C. G., Zehn, D. & Stepanek, O., 4 Feb 2020, In: Cell Reports. 30, 5, p. 1504-1514.e7

Research output: Contribution to journal › Article › peer-review

Open Access

30 Scopus citations

Lymphatic endothelial cells prime naïve CD8⁺ T cells into memory cells under steady-state conditions

Vokali, E., Yu, S. S., Hirosue, S., Rinçon-Restrepo, M., V. Duraes, F., Scherer, S., Corthésy-Henrioud, P., Kilarski, W. W., Mondino, A., Zehn, D., Hugues, S. & Swartz, M. A., 1 Dec 2020, In: Nature Communications. 11, 1, 538.

Research output: Contribution to journal › Article › peer-review

Open Access

51 Scopus citations

PTPN2 Deficiency Enhances Programmed T Cell Expansion and Survival Capacity of Activated T Cells

Flosbach, M., Oberle, S. G., Scherer, S., Zecha, J., von Hoesslin, M., Wiede, F., Chennupati, V., Cullen, J. G., List, M., Pauling, J. K., Baumbach, J., Kuster, B., Tiganis, T. & Zehn, D., 28 Jul 2020, In: Cell Reports. 32, 4, 107957.

Research output: Contribution to journal › Article › peer-review

Open Access

37 Scopus citations

Reduced mitochondrial resilience enables non-canonical induction of apoptosis after TNF receptor signaling in virus-infected hepatocytes

Lampl, S., Janas, M. K., Donakonda, S., Brugger, M., Lohr, K., Schneider, A., Manske, K., Sperl, L. E., Kläger, S., Küster, B., Wettmarshausen, J., Müller, C., Laschinger, M., Hartmann, D., Hüser, N., Perocchi, F., Schmitt-Kopplin, P., Hagn, F., Zender, L. & Hornung, V. & 16 others, Borner, C., Pichlmair, A., Kashkar, H., Klingenspor, M., Prinz, M., Schreiner, S., Conrad, M., Jost, P. J., Zischka, H., Steiger, K., Krönke, M., Zehn, D., Protzer, U., Heikenwälder, M., Knolle, P. A. & Wohlleber, D., Dec 2020, In: Journal of Hepatology. 73, 6, p. 1347-1359 13 p.

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

SARS-CoV-2 infections in cancer outpatients—Most infected patients are asymptomatic carriers without impact on chemotherapy

Hempel, L., Piehler, A., Pfaffl, M. W., Molnar, J., Kirchner, B., Robert, S., Veloso, J., Gandorfer, B., Trepotec, Z., Mederle, S., Keim, S., Milani, V., Ebner, F., Schweneker, K., Fleischmann, B., Kleespies, A., Scheiber, J., Hempel, D. & Zehn, D., 1 Nov 2020, In: Cancer Medicine. 9, 21, p. 8020-8028 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

13 Scopus citations

2019

Acetate Promotes T Cell Effector Function during Glucose Restriction

Qiu, J., Villa, M., Sanin, D. E., Buck, M. D., O'Sullivan, D., Ching, R., Matsushita, M., Grzes, K. M., Winkler, F., Chang, C. H., Curtis, J. D., Kyle, R. L., Van Teijlingen Bakker, N., Corrado, M., Haessler, F., Alfei, F., Edwards-Hicks, J., Maggi, L. B., Zehn, D. & Egawa, T. & 5 others, Bengsch, B., Klein Geltink, R. I., Jenuwein, T., Pearce, E. J. & Pearce, E. L., 14 May 2019, In: Cell Reports. 27, 7, p. 2063-2074.e5

Research output: Contribution to journal › Article › peer-review

Open Access

249 Scopus citations

Attenuation of chronic antiviral T-cell responses through constitutive COX2-dependent prostanoid synthesis by lymph node fibroblasts

Schaeuble, K., Cannelle, H., Favre, S., Huang, H. Y., Oberle, S. G., Speiser, D. E., Zehn, D. & Luther, S. A., Jul 2019, In: PLoS Biology. 17, 7, e3000072.

Research output: Contribution to journal › Article › peer-review

Open Access

20 Scopus citations

Defining ‘T cell exhaustion’

Blank, C. U., Haining, W. N., Held, W., Hogan, P. G., Kallies, A., Lugli, E., Lynn, R. C., Philip, M., Rao, A., Restifo, N. P., Schietinger, A., Schumacher, T. N., Schwartzberg, P. L., Sharpe, A. H., Speiser, D. E., Wherry, E. J., Youngblood, B. A. & Zehn, D., 1 Nov 2019, In: Nature Reviews Immunology. 19, 11, p. 665-674 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

1036 Scopus citations

Leveraging TCR affinity in adoptive immunotherapy against shared tumor/self-antigens

Miller, A. M., Bahmanof, M., Zehn, D., Cohen, E. E. W. & Schoenberger, S. P., Jan 2019, In: Cancer Immunology Research. 7, 1, p. 40-49 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

18 Scopus citations

MicroRNA-155 expression is enhanced by T-cell receptor stimulation strength and correlates with improved tumor control in Melanoma

Martinez-Usatorre, A., Sempere, L. F., Carmona, S. J., Carretero-Iglesia, L., Monnot, G., Speiser, D. E., Rufer, N., Donda, A., Zehn, D., Jandus, C. & Romero, P., Jun 2019, In: Cancer Immunology Research. 7, 6, p. 1013-1024 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

32 Scopus citations

MiR-23~27~24–mediated control of humoral immunity reveals a TOX-driven regulatory circuit in follicular helper T cell differentiation

Wu, C. J., Cho, S., Huang, H. Y., Lu, C. H., Russ, J., Cruz, L. O., da Cunha, F. F., Chen, M. C., Lin, L. L., Warner, L. M., Liao, H. K., Utzschneider, D. T., Quon, S., Berner, J., Camara, N. O. S., Zehn, D., Belmonte, J. C. I., Chen, L. C., Huang, S. F. & Kuo, M. L. & 1 others, Lu, L. F., 11 Dec 2019, In: Science Advances. 5, 12, eaaw1715.

Research output: Contribution to journal › Article › peer-review

Open Access

28 Scopus citations

Polyamines and eIF5A Hypusination Modulate Mitochondrial Respiration and Macrophage Activation

Puleston, D. J., Buck, M. D., Klein Geltink, R. I., Kyle, R. L., Caputa, G., O'Sullivan, D., Cameron, A. M., Castoldi, A., Musa, Y., Kabat, A. M., Zhang, Y., Flachsmann, L. J., Field, C. S., Patterson, A. E., Scherer, S., Alfei, F., Baixauli, F., Austin, S. K., Kelly, B. & Matsushita, M. & 17 others, Curtis, J. D., Grzes, K. M., Villa, M., Corrado, M., Sanin, D. E., Qiu, J., Pällman, N., Paz, K., Maccari, M. E., Blazar, B. R., Mittler, G., Buescher, J. M., Zehn, D., Rospert, S., Pearce, E. J., Balabanov, S. & Pearce, E. L., 6 Aug 2019, In: Cell Metabolism. 30, 2, p. 352-363.e8

Research output: Contribution to journal › Article › peer-review

Open Access

261 Scopus citations

Proliferation-competent Tcf1+ CD8 T cells in dysfunctional populations are CD4 T cell help independent

Kanev, K., Wu, M., Drews, A., Roelli, P., Wurmser, C., von Hösslin, M. & Zehn, D., 1 Oct 2019, In: Proceedings of the National Academy of Sciences of the United States of America. 116, 40, p. 20070-20076 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

36 Scopus citations

TOX reinforces the phenotype and longevity of exhausted T cells in chronic viral infection

Alfei, F., Kanev, K., Hofmann, M., Wu, M., Ghoneim, H. E., Roelli, P., Utzschneider, D. T., von Hoesslin, M., Cullen, J. G., Fan, Y., Eisenberg, V., Wohlleber, D., Steiger, K., Merkler, D., Delorenzi, M., Knolle, P. A., Cohen, C. J., Thimme, R., Youngblood, B. & Zehn, D., 11 Jul 2019, In: Nature. 571, 7764, p. 265-269 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

621 Scopus citations

2018

Expression of the DNA-Binding Factor TOX Promotes the Encephalitogenic Potential of Microbe-Induced Autoreactive CD8⁺ T Cells

Page, N., Klimek, B., De Roo, M., Steinbach, K., Soldati, H., Lemeille, S., Wagner, I., Kreutzfeldt, M., Di Liberto, G., Vincenti, I., Lingner, T., Salinas, G., Brück, W., Simons, M., Murr, R., Kaye, J., Zehn, D., Pinschewer, D. D. & Merkler, D., 15 May 2018, In: Immunity. 48, 5, p. 937-950.e8

Research output: Contribution to journal › Article › peer-review

Open Access

58 Scopus citations

PD-1 blockade unleashes effector potential of both high- and low-affinity tumor-infiltrating T cells

Martínez-Usatorre, A., Donda, A., Zehn, D. & Romero, P., 15 Jul 2018, In: Journal of Immunology. 201, 2, p. 792-803 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

24 Scopus citations

Perforin inhibition protects from lethal endothelial damage during fulminant viral hepatitis

Welz, M., Eickhoff, S., Abdullah, Z., Trebicka, J., Gartlan, K. H., Spicer, J. A., Demetris, A. J., Akhlaghi, H., Anton, M., Manske, K., Zehn, D., Nieswandt, B., Kurts, C., Trapani, J. A., Knolle, P., Wohlleber, D. & Kastenmüller, W., 1 Dec 2018, In: Nature Communications. 9, 1, 4805.

Research output: Contribution to journal › Article › peer-review

Open Access

29 Scopus citations

Shp-2 Is Dispensable for Establishing T Cell Exhaustion and for PD-1 Signaling In Vivo

Rota, G., Niogret, C., Dang, A. T., Barros, C. R., Fonta, N. P., Alfei, F., Morgado, L., Zehn, D., Birchmeier, W., Vivier, E. & Guarda, G., 3 Apr 2018, In: Cell Reports. 23, 1, p. 39-49 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

116 Scopus citations

Strong homeostatic TCR signals induce formation of self-tolerant virtual memory CD8 T cells

Drobek, A., Moudra, A., Mueller, D., Huranova, M., Horkova, V., Pribikova, M., Ivanek, R., Oberle, S., Zehn, D., McCoy, K. D., Draber, P. & Stepanek, O., 13 Jul 2018, In: EMBO Journal. 37, 14, e98518.

Research output: Contribution to journal › Article › peer-review

Open Access

59 Scopus citations

2017

Exacerbated Leishmaniasis Caused by a Viral Endosymbiont can be Prevented by Immunization with Its Viral Capsid

Castiglioni, P., Hartley, M. A., Rossi, M., Prevel, F., Desponds, C., Utzschneider, D. T., Eren, R. O., Zangger, H., Brunner, L., Collin, N., Zehn, D., Kuhlmann, F. M., Beverley, S. M., Fasel, N. & Ronet, C., 18 Jan 2017, In: PLoS Neglected Tropical Diseases. 11, 1, e0005240.

Research output: Contribution to journal › Article › peer-review

Open Access

31 Scopus citations

Dietmar Zehn

Research output

Search results