Anna Lena Illert

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Anna Lena Illert

Dr.med.

20022025

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  • 2025

    Comprehensive genomic and transcriptomic analysis enables molecularly guided therapy options in peritoneal and pleural mesothelioma

    Möhrmann, L., Werner, M., Oleś, M., Knol, L., Arnold, J. S., Mundt, T., Paramasivam, N., Richter, D., Fröhlich, M., Hutter, B., Hüllein, J., Jahn, A., Scheffold, C., Möhrmann, E. E., Hanf, D., Kreutzfeldt, S., Heilig, C. E., Teleanu, M. V., Lipka, D. B. & Beck, K. & 17 others, Baude-Müller, A., Jelas, I., Rieke, D. T., Klotz, L. V., Shah, R., Herold, T., Boerries, M., Illert, A. L., Allgäuer, M., Stenzinger, A., Kerle, I. A., Horak, P., Heining, C., Schröck, E., Hübschmann, D., Fröhling, S. & Glimm, H., Apr 2025, In: ESMO Open. 10, 4, 104532.

    Research output: Contribution to journal › Article › peer-review

    Open Access

  • Genomic landscape and molecularly informed therapy in thymic carcinoma and other advanced thymic epithelial tumors

    Möhrmann, L., Rostock, L., Werner, M., Oleś, M., Arnold, J. S., Paramasivam, N., Jöhrens, K., Rupp, L., Schmitz, M., Richter, D., Uhrig, S., Fröhlich, M., Hutter, B., Hüllein, J., Jahn, A., Arlt, M., Möhrmann, E. E., Hanf, D., Gieldon, L. & Kreutzfeldt, S. & 29 others, Heilig, C. E., Teleanu, M. V., Lipka, D. B., Beck, K., Baude-Müller, A., Mock, A., Jelas, I., Rieke, D. T., Wiesweg, M., Brandts, C., Boerries, M., Illert, A. L., Desuki, A., Kindler, T., Krackhardt, A. M., Westphalen, C. B., Christopoulos, P., Apostolidis, L., Stenzinger, A., Allgäuer, M., Neumann, O., Kerle, I. A., Horak, P., Heining, C., Grosch, H., Schröck, E., Hübschmann, D., Fröhling, S. & Glimm, H., 2025, (Accepted/In press) In: Med. 100612.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    1 Scopus citations

  • Liver-FDG-uptake augments early PET/CT prognostic value for CD19-targeted CAR-T cell therapy in diffuse large B cell lymphoma

    Beck, M., Blumenberg, V., Bücklein, V. L., Bundschuh, R. A., Harrer, D. C., Hirschbühl, K., Jung, J., Kunz, W. G., Menhart, K., Winkelmann, M., Yakushev, I., Illert, A. L., Eckstein, M., Völkl, S., Claus, R., Hansmann, L., Hecker, J. S., Kuwert, T., Mackensen, A. & Subklewe, M. & 2 others, Hellwig, D. & Müller, F., Dec 2025, In: EJNMMI Research. 15, 1, 25.

    Research output: Contribution to journal › Article › peer-review

    Open Access

  • MRD-guided zanubrutinib, venetoclax, and obinutuzumab in relapsed CLL: primary end point analysis from the CLL2-BZAG trial

    Fürstenau, M., Robrecht, S., Schneider, C., Tausch, E., Giza, A., Ritgen, M., Bittenbring, J., Hebart, H., Schöttker, B., Illert, A. L., Graeven, U., Stoltefuß, A., Heinrich, B., Eckert, R., Fink, A., Stumpf, J., Fischer, K., Al-Sawaf, O., Simon, F. & Kleinert, F. & 9 others, Weiss, J., Kreuzer, K. A., Schilhabel, A., Brüggemann, M., Langerbeins, P., Stilgenbauer, S., Eichhorst, B., Hallek, M. & Cramer, P., 2025, (Accepted/In press) In: Blood.

    Research output: Contribution to journal › Article › peer-review

    1 Scopus citations
  • 2024

    Comprehensive genetic profiling and molecularly guided treatment for patients with primary CNS tumors

    Kuehn, J. C., Metzger, P., Neidert, N., Matysiak, U., Gräßel, L., Philipp, U., Bleul, S., Pauli, T., Falkenstein, J., Bertemes, H., Cysar, S., Hess, M. E., Frey, A. V., Duque-Afonso, J., Schorb, E., Machein, M., Beck, J., Schnell, O., von Bubnoff, N. & Illert, A. L. & 12 others, Peters, C., Brummer, T., Prinz, M., Miething, C., Becker, H., Lassmann, S., Werner, M., Börries, M., Duyster, J., Heiland, D. H., Sankowski, R. & Scherer, F., Dec 2024, In: npj Precision Oncology. 8, 1, 180.

    Research output: Contribution to journal › Article › peer-review

    Open Access

  • Expert-Guided Large Language Models for Clinical Decision Support in Precision Oncology

    Lammert, J., Dreyer, T., Mathes, S., Kuligin, L., Borm, K. J., Schatz, U. A., Kiechle, M., Lörsch, A. M., Jung, J., Lange, S., Pfarr, N., Durner, A., Schwamborn, K., Winter, C., Ferber, D., Kather, J. N., Mogler, C., Illert, A. L. & Tschochohei, M., 1 Oct 2024, In: JCO Precision Oncology. 8, e2400478.

    Research output: Contribution to journal › Article › peer-review

    2 Scopus citations

  • Gene editing of hematopoietic stem cells restores T-cell response in familial hemophagocytic lymphohistiocytosis

    Dettmer-Monaco, V., Weißert, K., Ammann, S., Monaco, G., Lei, L., Gräßel, L., Rhiel, M., Rositzka, J., Kaufmann, M. M., Geiger, K., Andrieux, G., Lao, J., Thoulass, G., Schell, C., Boerries, M., Illert, A. L., Cornu, T. I., Ehl, S., Aichele, P. & Cathomen, T., Jan 2024, In: Journal of Allergy and Clinical Immunology. 153, 1, p. 243-255.e14

    Research output: Contribution to journal › Article › peer-review

    Open Access
    8 Scopus citations

  • Oncogene-induced TIM-3 ligand expression dictates susceptibility to anti–TIM-3 therapy in mice

    Talvard-Balland, N., Braun, L. M., Dixon, K. O., Zwick, M., Engel, H., Hartmann, A., Duquesne, S., Penter, L., Andrieux, G., Rindlisbacher, L., Acerbis, A., Ehmann, J., Köllerer, C., Ansuinelli, M., Rettig, A., Moschallski, K., Apostolova, P., Brummer, T., Illert, A. L. & Schramm, M. A. & 22 others, Cheng, Y., Köttgen, A., Duyster, J., Menssen, H. D., Ritz, J., Blazar, B. R., Boerries, M., Schmitt-Gräff, A., Sariipek, N., Van Galen, P., Buescher, J. M., Cabezas-Wallscheid, N., Pahl, H. L., Pearce, E. L., Soiffer, R. J., Wu, C. J., Vago, L., Becher, B., Köhler, N., Wertheimer, T., Kuchroo, V. K. & Zeiser, R., 2024, In: Journal of Clinical Investigation. 134, 16, e177460.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    7 Scopus citations

  • Personalisierte Medizin in der Onkologie

    Translated title of the contribution: Personalized medicine in oncologyLörsch, A. M., Jung, J., Lange, S., Pfarr, N., Mogler, C. & Illert, A. L., May 2024, In: Pathologie. 45, 3, p. 180-189 10 p.

    Research output: Contribution to journal › Article › peer-review

    2 Scopus citations

  • PM4Onco: personalisierte Medizin für die Onkologie: Effektive Datennutzung für molekulare Tumorboards

    Translated title of the contribution: PM4Onco: personalized medicine for oncology: Effective use of data for molecular tumor boardsPflugradt, L., Metzger, P., Gräßel, L., Strantz, C., Blaumeiser, A., Busch, H., Steinwachs, M., Illert, A. L., Zeissig, S. R. & Boerries, M., Oct 2024, In: Onkologie. 30, 10, p. 898-904 7 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access

  • Primary Results of Patients with Genitourinary Malignancies Presented at a Molecular Tumor Board

    Michaelis, J., Himmelsbach, R., Metzger, P., Lassmann, S., Börries, M., Werner, M., Miething, C., Höfflin, R., Illert, A. L., Duyster, J., Becker, H., Sigle, A., Gratzke, C. & Grabbert, M., 1 Oct 2024, In: Urologia Internationalis. 108, 5, p. 383-391 9 p.

    Research output: Contribution to journal › Article › peer-review

  • The role of molecular tumor boards in neuro-oncology: a nationwide survey

    Hönikl, L. S., Lange, S., Butenschoen, V. M., Delbridge, C., Meyer, B., Combs, S. E., Illert, A. L. & Schmidt-Graf, F., Dec 2024, In: BMC Cancer. 24, 1, 108.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    3 Scopus citations
  • 2023

    CXCR4-targeted Theranostics in Hematooncology: Opportunities and Challenges

    Werner, R., Haug, A., Buske, C., Heidegger, S., Illert, A. L., Bassermann, F., Herhaus, P., Buck, A., Duell, J., Topp, M. S., Kraus, S., Einsele, H., Lapa, C., Raderer, M., Lenz, G., Habringer, S., von Tresckow, B. & Keller, U., 9 Aug 2023, In: NuklearMedizin. 63, 2, p. 57-61 5 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    3 Scopus citations

  • Development of Highly Sensitive Digital Droplet PCR for Detection of cKIT Mutations in Circulating Free DNA That Mediate Resistance to TKI Treatment for Gastrointestinal Stromal Tumor (GIST)

    Rassner, M., Waldeck, S., Follo, M., Jilg, S., Philipp, U., Jolic, M., Wehrle, J., Jost, P. J., Peschel, C., Illert, A. L., Duyster, J., Scherer, F. & von Bubnoff, N., Mar 2023, In: International Journal of Molecular Sciences. 24, 6, 5411.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    3 Scopus citations

  • Final analysis of the CLL2-GIVe trial: obinutuzumab, ibrutinib, and venetoclax for untreated CLL with del(17p)/TP53mut

    Huber, H., Tausch, E., Schneider, C., Edenhofer, S., von Tresckow, J., Robrecht, S., Giza, A., Zhang, C., Fürstenau, M., Dreger, P., Ritgen, M., Illmer, T., Illert, A. L., Dürig, J., Böttcher, S., Niemann, C. U., Kneba, M., Al-Sawaf, O., Kreuzer, K. A. & Fink, A. M. & 5 others, Fischer, K., Döhner, H., Hallek, M., Eichhorst, B. & Stilgenbauer, S., 14 Sep 2023, In: Blood. 142, 11, p. 961-972 12 p.

    Research output: Contribution to journal › Article › peer-review

    33 Scopus citations

  • MIRACUM-Pipe: An Adaptable Pipeline for Next-Generation Sequencing Analysis, Reporting, and Visualization for Clinical Decision Making

    Metzger, P., Hess, M. E., Blaumeiser, A., Pauli, T., Schipperges, V., Mertes, R., Christoph, J., Unberath, P., Reimer, N., Scheible, R., Illert, A. L., Busch, H., Andrieux, G. & Boerries, M., Jul 2023, In: Cancers. 15, 13, 3456.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    10 Scopus citations

  • Multicentric pilot study to standardize clinical whole exome sequencing (WES) for cancer patients

    Menzel, M., Ossowski, S., Kral, S., Metzger, P., Horak, P., Marienfeld, R., Boerries, M., Wolter, S., Ball, M., Neumann, O., Armeanu-Ebinger, S., Schroeder, C., Matysiak, U., Goldschmid, H., Schipperges, V., Fürstberger, A., Allgäuer, M., Eberhardt, T., Niewöhner, J. & Blaumeiser, A. & 24 others, Ploeger, C., Haack, T. B., Tay, T. K. Y., Kelemen, O., Pauli, T., Kirchner, M., Kluck, K., Ott, A., Renner, M., Admard, J., Gschwind, A., Lassmann, S., Kestler, H., Fend, F., Illert, A. L., Werner, M., Möller, P., Seufferlein, T. T. W., Malek, N., Schirmacher, P., Fröhling, S., Kazdal, D., Budczies, J. & Stenzinger, A., Dec 2023, In: npj Precision Oncology. 7, 1, 106.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    17 Scopus citations

  • Profile of the multicenter cohort of the German Cancer Consortium’s Clinical Communication Platform

    Maier, D., Vehreschild, J. J., Uhl, B., Meyer, S., Berger-Thürmel, K., Boerries, M., Braren, R., Grünwald, V., Hadaschik, B., Palm, S., Singer, S., Stuschke, M., Juárez, D., Delpy, P., Lambarki, M., Hummel, M., Engels, C., Andreas, S., Gökbuget, N. & Ihrig, K. & 47 others, Burock, S., Keune, D., Eggert, A., Keilholz, U., Schulz, H., Büttner, D., Löck, S., Krause, M., Esins, M., Ressing, F., Schuler, M., Brandts, C., Brucker, D. P., Husmann, G., Oellerich, T., Metzger, P., Voigt, F., Illert, A. L., Theobald, M., Kindler, T., Sudhof, U., Reckmann, A., Schwinghammer, F., Nasseh, D., Weichert, W., von Bergwelt-Baildon, M., Bitzer, M., Malek, N., Öner, Ö., Schulze-Osthoff, K., Bartels, S., Haier, J., Ammann, R., Schmidt, A. F., Guenther, B., Janning, M., Kasper, B., Loges, S., Stilgenbauer, S., Kuhn, P., Tausch, E., Runow, S., Kerscher, A., Neumann, M., Breu, M., Lablans, M. & Serve, H., May 2023, In: European Journal of Epidemiology. 38, 5, p. 573-586 14 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    4 Scopus citations
  • 2022

    Bcl-xL as prognostic marker and potential therapeutic target in cholangiocarcinoma

    Hoffmeister-Wittmann, P., Mock, A., Nichetti, F., Korell, F., Heilig, C. E., Scherr, A. L., Günther, M., Albrecht, T., Kelmendi, E., Xu, K., Nader, L., Kessler, A., Schmitt, N., Fritzsche, S., Weiler, S., Sobol, B., Stenzinger, A., Boeck, S., Westphalen, C. B. & Schulze-Osthoff, K. & 28 others, Trojan, J., Kindler, T., Weichert, W., Spiekermann, K., Bitzer, M., Folprecht, G., Illert, A. L., Boerries, M., Klauschen, F., Ochsenreither, S., Siveke, J., Bauer, S., Glimm, H., Brors, B., Hüllein, J., Hübschmann, D., Uhrig, S., Horak, P., Kreutzfeldt, S., Banales, J. M., Springfeld, C., Jäger, D., Schirmacher, P., Roessler, S., Ormanns, S., Goeppert, B., Fröhling, S. & Köhler, B. C., Dec 2022, In: Liver International. 42, 12, p. 2855-2870 16 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    8 Scopus citations

  • Comprehensive cancer predisposition testing within the prospective MASTER trial identifies hereditary cancer patients and supports treatment decisions for rare cancers

    Jahn, A., Rump, A., Widmann, T. J., Heining, C., Horak, P., Hutter, B., Paramasivam, N., Uhrig, S., Gieldon, L., Drukewitz, S., Kübler, A., Bermudez, M., Hackmann, K., Porrmann, J., Wagner, J., Arlt, M., Franke, M., Fischer, J., Kowalzyk, Z. & William, D. & 58 others, Weth, V., Oster, S., Fröhlich, M., Hüllein, J., Valle González, C., Kreutzfeldt, S., Mock, A., Heilig, C. E., Lipka, D. B., Möhrmann, L., Hanf, D., Oleś, M., Teleanu, V., Allgäuer, M., Ruhnke, L., Kutz, O., Knurr, A., Laßmann, A., Endris, V., Neumann, O., Penzel, R., Beck, K., Richter, D., Winter, U., Wolf, S., Pfütze, K., Geörg, C., Meißburger, B., Buchhalter, I., Augustin, M., Aulitzky, W. E., Hohenberger, P., Kroiss, M., Schirmacher, P., Schlenk, R. F., Keilholz, U., Klauschen, F., Folprecht, G., Bauer, S., Siveke, J. T., Brandts, C. H., Kindler, T., Boerries, M., Illert, A. L., von Bubnoff, N., Jost, P. J., Metzeler, K. H., Bitzer, M., Schulze-Osthoff, K., von Kalle, C., Brors, B., Stenzinger, A., Weichert, W., Hübschmann, D., Fröhling, S., Glimm, H., Schröck, E. & Klink, B., Nov 2022, In: Annals of Oncology. 33, 11, p. 1186-1199 14 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    35 Scopus citations

  • Comprehensive genomic and epigenomic analysis in cancer of unknown primary guides molecularly-informed therapies despite heterogeneity

    Möhrmann, L., Werner, M., Oleś, M., Mock, A., Uhrig, S., Jahn, A., Kreutzfeldt, S., Fröhlich, M., Hutter, B., Paramasivam, N., Richter, D., Beck, K., Winter, U., Pfütze, K., Heilig, C. E., Teleanu, V., Lipka, D. B., Zapatka, M., Hanf, D. & List, C. & 24 others, Allgäuer, M., Penzel, R., Rüter, G., Jelas, I., Hamacher, R., Falkenhorst, J., Wagner, S., Brandts, C. H., Boerries, M., Illert, A. L., Metzeler, K. H., Westphalen, C. B., Desuki, A., Kindler, T., Folprecht, G., Weichert, W., Brors, B., Stenzinger, A., Schröck, E., Hübschmann, D., Horak, P., Heining, C., Fröhling, S. & Glimm, H., Dec 2022, In: Nature Communications. 13, 1, 4485.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    36 Scopus citations

  • First-in-human study of WT1 recombinant protein vaccination in elderly patients with AML in remission: a single-center experience

    Kreutmair, S., Pfeifer, D., Waterhouse, M., Takács, F., Graessel, L., Döhner, K., Duyster, J., Illert, A. L., Frey, A. V., Schmitt, M. & Lübbert, M., Dec 2022, In: Cancer Immunology, Immunotherapy. 71, 12, p. 2913-2928 16 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    16 Scopus citations

  • Gab2 deficiency prevents Flt3-ITD driven acute myeloid leukemia in vivo

    Spohr, C., Poggio, T., Andrieux, G., Schönberger, K., Cabezas-Wallscheid, N., Boerries, M., Halbach, S., Illert, A. L. & Brummer, T., Apr 2022, In: Leukemia. 36, 4, p. 970-982 13 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    4 Scopus citations

  • Gene expression-based prediction of pazopanib efficacy in sarcoma

    Heilig, C. E., Laßmann, A., Mughal, S. S., Mock, A., Pirmann, S., Teleanu, V., Renner, M., Andresen, C., Köhler, B. C., Aybey, B., Bauer, S., Siveke, J. T., Hamacher, R., Folprecht, G., Richter, S., Schröck, E., Brandts, C. H., Ahrens, M., Hohenberger, P. & Egerer, G. & 27 others, Kindler, T., Boerries, M., Illert, A. L., von Bubnoff, N., Apostolidis, L., Jost, P. J., Westphalen, C. B., Weichert, W., Keilholz, U., Klauschen, F., Beck, K., Winter, U., Richter, D., Möhrmann, L., Bitzer, M., Schulze-Osthoff, K., Brors, B., Mechtersheimer, G., Kreutzfeldt, S., Heining, C., Lipka, D. B., Stenzinger, A., Schlenk, R. F., Horak, P., Glimm, H., Hübschmann, D. & Fröhling, S., Sep 2022, In: European Journal of Cancer. 172, p. 107-118 12 p.

    Research output: Contribution to journal › Article › peer-review

    4 Scopus citations

  • NIPA (Nuclear Interaction Partner of ALK) Is Crucial for Effective NPM-ALK Mediated Lymphomagenesis

    Kreutmair, S., Lippert, L. J., Klingeberg, C., Albers-Leischner, C., Yacob, S., Shlyakhto, V., Mueller, T., Mueller-Rudorf, A., Yu, C., Gorantla, S. P., Miething, C., Duyster, J. & Illert, A. L., 13 May 2022, In: Frontiers in Oncology. 12, 875117.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    1 Scopus citations

  • Obinutuzumab (GA-101), ibrutinib, and venetoclax (GIVe) frontline treatment for high-risk chronic lymphocytic leukemia

    Huber, H., Edenhofer, S., von Tresckow, J., Robrecht, S., Zhang, C., Tausch, E., Schneider, C., Bloehdorn, J., Fürstenau, M., Dreger, P., Ritgen, M., Illmer, T., Illert, A. L., Dürig, J., Böttcher, S., Niemann, C. U., Kneba, M., Fink, A. M., Fischer, K. & Döhner, H. & 3 others, Hallek, M., Eichhorst, B. & Stilgenbauer, S., 3 Mar 2022, In: Blood. 139, 9, p. 1318-1329 12 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    35 Scopus citations

  • Targeting MDM2 enhances antileukemia immunity after allogeneic transplantation via MHC-II and TRAIL-R1/2 upregulation

    Ho, J. N. H. G., Schmidt, D., Lowinus, T., Ryoo, J., Dopfer, E. P., Gonzalo Núñez, N., Costa-Pereira, S., Toffalori, C., Punta, M., Fetsch, V., Wertheimer, T., Rittmann, M. C., Braun, L. M., Follo, M., Briere, C., Vinnakota, J. M., Langenbach, M., Koppers, F., Shoumariyeh, K. & Engel, H. & 23 others, Rückert, T., Märklin, M., Holzmayer, S., Illert, A. L., Magon, F., Andrieux, G., Duquesne, S., Pfeifer, D., Staniek, J., Rizzi, M., Miething, C., Köhler, N., Duyster, J., Menssen, H. D., Boerries, M., Buescher, J. M., Cabezas-Wallscheid, N., Blazar, B. R., Apostolova, P., Vago, L., Pearce, E. L., Becher, B. & Zeiser, R., 8 Sep 2022, In: Blood. 140, 10, p. 1167-1181 15 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    38 Scopus citations

  • The IL-3, IL-5, and GM-CSF common receptor beta chain mediates oncogenic activity of FLT3-ITD-positive AML

    Charlet, A., Kappenstein, M., Keye, P., Kläsener, K., Endres, C., Poggio, T., Gorantla, S. P., Kreutmair, S., Sänger, J., Illert, A. L., Miething, C., Reth, M., Duyster, J., Rummelt, C. & von Bubnoff, N., Mar 2022, In: Leukemia. 36, 3, p. 701-711 11 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    13 Scopus citations
  • 2021

    Blockade of tumor necrosis factor superfamily members CD30 and OX40 abrogates disease activity in murine immune-mediated glomerulonephritis

    Artinger, K., Kirsch, A. H., Mooslechner, A. A., Cooper, D. J., Aringer, I., Schuller, M., Schabhüttl, C., Klötzer, K. A., Schweighofer, K., Eller, P., Yagita, H., Illert, A. L., Rosenkranz, A. R., Lane, P. J. & Eller, K., Aug 2021, In: Kidney International. 100, 2, p. 336-348 13 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    6 Scopus citations

  • Comprehensive genomic and transcriptomic analysis for guiding therapeutic decisions in patients with rare cancers

    Horak, P., Heining, C., Kreutzfeldt, S., Hutter, B., Mock, A., Hüllein, J., Fröhlich, M., Uhrig, S., Jahn, A., Rump, A., Gieldon, L., Möhrmann, L., Hanf, D., Teleanu, V., Heilig, C. E., Lipka, D. B., Allgäuer, M., Ruhnke, L., Laßmann, A. & Endris, V. & 39 others, Neumann, O., Penzel, R., Beck, K., Richter, D., Winter, U., Wolf, S., Pfütze, K., Geörg, C., Meißburger, B., Buchhalter, I., Augustin, M., Aulitzky, W. E., Hohenberger, P., Kroiss, M., Schirmacher, P., Schlenk, R. F., Keilholz, U., Klauschen, F., Folprecht, G., Bauer, S., Siveke, J. T., Brandts, C. H., Kindler, T., Boerries, M., Illert, A. L., Von Bubnoff, N., Jost, P. J., Spiekermann, K., Bitzer, M., Schulze-Osthoff, K., Von Kalle, C., Klink, B., Brors, B., Stenzinger, A., Schröck, E., Hübschmann, D., Weichert, W., Glimm, H. & Fröhling, S., Nov 2021, In: Cancer Discovery. 11, 11, p. 2780-2795 16 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    173 Scopus citations

  • Rationale and design of the CRAFT (Continuous ReAssessment with Flexible ExTension in Rare Malignancies) multicenter phase II trial

    Heilig, C. E., Horak, P., Kreutzfeldt, S., Teleanu, V., Mock, A., Renner, M., Bhatti, I. A., Hutter, B., Hüllein, J., Fröhlich, M., Uhrig, S., Süße, H., Heiligenthal, L., Ochsenreither, S., Illert, A. L., Vogel, A., Desuki, A., Heinemann, V., Heidegger, S. & Bitzer, M. & 12 others, Scheytt, M., Brors, B., Hübschmann, D., Baretton, G., Stenzinger, A., Steindorf, K., Benner, A., Jäger, D., Heining, C., Glimm, H., Fröhling, S. & Schlenk, R. F., Dec 2021, In: ESMO Open. 6, 6, 100310.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    7 Scopus citations

  • Transitioning the molecular tumor board from proof of concept to clinical routine: A german single-center analysis

    Hoefflin, R., Lazarou, A., Hess, M. E., Reiser, M., Wehrle, J., Metzger, P., Frey, A. V., Becker, H., Aumann, K., Berner, K., Boeker, M., Buettner, N., Dierks, C., Duque-Afonso, J., Eisenblaetter, M., Erbes, T., Fritsch, R., Ge, I. X., Geißler, A. L. & Grabbert, M. & 25 others, Heeg, S., Heiland, D. H., Hettmer, S., Kayser, G., Keller, A., Kleiber, A., Kutilina, A., Mehmed, L., Meiss, F., Poxleitner, P., Rawluk, J., Ruf, J., Schäfer, H., Scherer, F., Shoumariyeh, K., Tzschach, A., Peters, C., Brummer, T., Werner, M., Duyster, J., Lassmann, S., Miething, C., Boerries, M., Illert, A. L. & Bubnoff, N. V., 1 Mar 2021, In: Cancers. 13, 5, p. 1-18 18 p., 1151.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    33 Scopus citations
  • 2020

    A novel conditional NPM-ALK-driven model of CD30+ T-cell lymphoma mediated by a translational stop cassette

    Shoumariyeh, K., Schneider, N., Poggio, T., Veratti, P., Ehrenfeld, S., Redhaber, D. M., Khan, R., Pfeifer, D., Klingeberg, C., Kreutmair, S., Rudelius, M., Quintanilla-Martinez, L., Fend, F., Illert, A. L., Duyster, J. & Miething, C., 27 Feb 2020, In: Oncogene. 39, 9, p. 1904-1913 10 p.

    Research output: Contribution to journal › Article › peer-review

    3 Scopus citations

  • Existence of reprogrammed lymphoma stem cells in a murine ALCL-like model

    Kreutmair, S., Klingeberg, C., Poggio, T., Andrieux, G., Keller, A., Miething, C., Follo, M., Pfeifer, D., Shoumariyeh, K., Lengerke, C., Gonzalez-Menendez, I., Fend, F., Zeiser, R., Turner, S. D., Quintanilla-Martinez, L., Boerries, M., Duyster, J. & Illert, A. L., Dec 2020, In: Leukemia. 34, 12, p. 3242-3255 14 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    5 Scopus citations

  • Identification of BCL-XL as highly active survival factor and promising therapeutic target in colorectal cancer

    Scherr, A. L., Mock, A., Gdynia, G., Schmitt, N., Heilig, C. E., Korell, F., Rhadakrishnan, P., Hoffmeister, P., Metzeler, K. H., Schulze-Osthoff, K., Illert, A. L., Boerries, M., Trojan, J., Waidmann, O., Falkenhorst, J., Siveke, J., Jost, P. J., Bitzer, M., Malek, N. P. & Vecchione, L. & 14 others, Jelas, I., Brors, B., Glimm, H., Stenzinger, A., Grekova, S. P., Gehrig, T., Schulze-Bergkamen, H., Jäger, D., Schirmacher, P., Heikenwalder, M., Goeppert, B., Schneider, M., Fröhling, S. & Köhler, B. C., 1 Oct 2020, In: Cell Death and Disease. 11, 10, 875.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    28 Scopus citations

  • Loss of the Fanconi anemia-associated protein NIPA causes bone marrow failure

    Kreutmair, S., Erlacher, M., Andrieux, G., Istvanffy, R., Mueller-Rudorf, A., Zwick, M., Rückert, T., Pantic, M., Poggio, T., Shoumariyeh, K., Mueller, T. A., Kawaguchi, H., Follo, M., Klingeberg, C., Wlodarski, M., Baumann, I., Pfeifer, D., Kulinski, M., Rudelius, M. & Lemeer, S. & 14 others, Kuster, B., Dierks, C., Peschel, C., Cabezas-Wallscheid, N., Duque-Afonso, J., Zeiser, R., Cleary, M. L., Schindler, D., Schmitt-Graeff, A., Boerries, M., Niemeyer, C. M., Oostendorp, R. A. J., Duyster, J. & Illert, A. L., 1 Jun 2020, In: Journal of Clinical Investigation. 130, 6, p. 2827-2844 18 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    8 Scopus citations

  • Personalized treatment selection and disease monitoring using circulating tumor DNA profiling in real-world cancer patient management

    Wehrle, J., Philipp, U., Jolic, M., Follo, M., Hussung, S., Waldeck, S., Deuter, M., Rassner, M., Braune, J., Rawluk, J., Greil, C., Waller, C. F., Becker, H., Duque-Afonso, J., Illert, A. L., Fritsch, R. M., Meiss, F., Duyster, J., von Bubnoff, N. & Scherer, F., Aug 2020, In: Diagnostics. 10, 8, 550.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    9 Scopus citations

  • Phosphorylation of BECLIN-1 by BCR-ABL suppresses autophagy in chronic myeloid leukemia

    Yu, C., Gorantla, S. P., Müller-Rudorf, A., Müller, T. A., Kreutmair, S., Albers, C., Jakob, L., Lippert, L. J., Yue, Z., Engelhardt, M., Follo, M., Zeiser, R., Huber, T. B., Duyster, J. & Illert, A. L., May 2020, In: Haematologica. 105, 5, p. 1285-1293 9 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    23 Scopus citations
  • 2019

    APC/C Cdh1 regulates the balance between maintenance and differentiation of hematopoietic stem and progenitor cells

    Ewerth, D., Kreutmair, S., Schmidts, A., Ihorst, G., Follo, M., Wider, D., Felthaus, J., Schüler, J., Duyster, J., Illert, A. L., Engelhardt, M. & Wäsch, R., 30 Jan 2019, In: Cellular and Molecular Life Sciences. 76, 2, p. 369-380 12 p.

    Research output: Contribution to journal › Article › peer-review

    5 Scopus citations

  • NPM1c alters FLT3-D835Y localization and signaling in acute myeloid leukemia

    Rudorf, A., Müller, T. A., Klingeberg, C., Kreutmair, S., Poggio, T., Gorantla, S. P., Rückert, T., Schmitt-Graeff, A., Gengenbacher, A., Paschka, P., Baldus, C., Zeiser, R., Vassiliou, G. S., Bradley, A., Duyster, J. & Illert, A. L., 25 Jul 2019, In: Blood. 134, 4, p. 383-388 6 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    14 Scopus citations

  • Proteomic phosphosite analysis identified crucial NPM-ALK-Mediated NIPA Serine and Threonine Residues

    Gengenbacher, A., Müller-Rudorf, A., Poggio, T., Gräßel, L., Dumit, V. I., Kreutmair, S., Lippert, L. J., Duyster, J. & Illert, A. L., 2 Aug 2019, In: International Journal of Molecular Sciences. 20, 16, 4060.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    4 Scopus citations
  • 2018

    Oncogenic JAK2 V617F causes PD-L1 expression, mediating immune escape in myeloproliferative neoplasms

    Prestipino, A., Emhardt, A. J., Aumann, K., O'Sullivan, D., Gorantla, S. P., Duquesne, S., Melchinger, W., Braun, L., Vuckovic, S., Boerries, M., Busch, H., Halbach, S., Pennisi, S., Poggio, T., Apostolova, P., Veratti, P., Hettich, M., Niedermann, G., Bartholomä, M. & Shoumariyeh, K. & 29 others, Jutzi, J. S., Wehrle, J., Dierks, C., Becker, H., Schmitt-Graeff, A., Follo, M., Pfeifer, D., Rohr, J., Fuchs, S., Ehl, S., Hartl, F. A., Minguet, S., Miething, C., Heidel, F. H., Kröger, N., Triviai, I., Brummer, T., Finke, J., Illert, A. L., Ruggiero, E., Bonini, C., Duyster, J., Pahl, H. L., Lane, S. W., Hill, G. R., Blazar, B. R., Von Bubnoff, N., Pearce, E. L. & Zeiser, R., 21 Feb 2018, In: Science Translational Medicine. 10, 429, eaam7729.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    190 Scopus citations

  • Phosphorylation of SOS1 on tyrosine 1196 promotes its RAC GEF activity and contributes to BCR-ABL leukemogenesis

    Gerboth, S., Frittoli, E., Palamidessi, A., Baltanas, F. C., Salek, M., Rappsilber, J., Giuliani, C., Troglio, F., Rolland, Y., Pruneri, G., Kreutmair, S., Pallavicini, I., Zobel, M., Cinquanta, M., Minucci, S., Gomez, C., Santos, E., Illert, A. L. & Scita, G., 1 Mar 2018, In: Leukemia. 32, 3, p. 820-827 8 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    27 Scopus citations

  • Sorafenib promotes graft-versus-leukemia activity in mice and humans through IL-15 production in FLT3-ITD-mutant leukemia cells

    Mathew, N. R., Baumgartner, F., Braun, L., O'Sullivan, D., Thomas, S., Waterhouse, M., Müller, T. A., Hanke, K., Taromi, S., Apostolova, P., Illert, A. L., Melchinger, W., Duquesne, S., Schmitt-Graeff, A., Osswald, L., Yan, K. L., Weber, A., Tugues, S., Spath, S. & Pfeifer, D. & 110 others, Follo, M., Claus, R., Lübbert, M., Rummelt, C., Bertz, H., Wäsch, R., Haag, J., Schmidts, A., Schultheiss, M., Bettinger, D., Thimme, R., Ullrich, E., Tanriver, Y., Vuong, G. L., Arnold, R., Hemmati, P., Wolf, D., Ditschkowski, M., Jilg, C., Wilhelm, K., Leiber, C., Gerull, S., Halter, J., Lengerke, C., Pabst, T., Schroeder, T., Kobbe, G., Rösler, W., Doostkam, S., Meckel, S., Stabla, K., Metzelder, S. K., Halbach, S., Brummer, T., Hu, Z., Dengjel, J., Hackanson, B., Schmid, C., Holtick, U., Scheid, C., Spyridonidis, A., Stölzel, F., Ordemann, R., Müller, L. P., Sicre-De-Fontbrune, F., Ihorst, G., Kuball, J., Ehlert, J. E., Feger, D., Wagner, E. M., Cahn, J. Y., Schnell, J., Kuchenbauer, F., Bunjes, D., Chakraverty, R., Richardson, S., Gill, S., Kröger, N., Ayuk, F., Vago, L., Ciceri, F., Müller, A. M., Kondo, T., Teshima, T., Klaeger, S., Kuster, B., Kim, D. H., Weisdorf, D., Van Der Velden, W., Dörfel, D., Bethge, W., Hilgendorf, I., Hochhaus, A., Andrieux, G., Börries, M., Busch, H., Magenau, J., Reddy, P., Labopin, M., Antin, J. H., Henden, A. S., Hill, G. R., Kennedy, G. A., Bar, M., Sarma, A., McLornan, D., Mufti, G., Oran, B., Rezvani, K., Shah, O., Negrin, R. S., Nagler, A., Prinz, M., Burchert, A., Neubauer, A., Beelen, D., Mackensen, A., Von Bubnoff, N., Herr, W., Becher, B., Socié, G., Caligiuri, M. A., Ruggiero, E., Bonini, C., Häcker, G., Duyster, J., Finke, J., Pearce, E., Blazar, B. R. & Zeiser, R., 1 Mar 2018, In: Nature Medicine. 24, 3, p. 282-291 10 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    234 Scopus citations
  • 2017

    Mycobacteria exploit nitric oxide-induced transformation of macrophages into permissive giant cells

    Gharun, K., Senges, J., Seidl, M., Lösslein, A., Kolter, J., Lohrmann, F., Fliegauf, M., Elgizouli, M., Vavra, M., Schachtrup, K., Illert, A. L., Gilleron, M., Kirschning, C. J., Triantafyllopoulou, A. & Henneke, P., Dec 2017, In: EMBO Reports. 18, 12, p. 2144-2159 16 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    26 Scopus citations
  • 2016

    Immuno-PET imaging of CD30-positive lymphoma using 89Zr-desferrioxamine-labeled CD30-specific ac-10 antibody

    Rylova, S. N., Del Pozzo, L., Klingeberg, C., Tönnesmann, R., Illert, A. L., Meyer, P. T., Maecke, H. R. & Holland, J. P., 1 Jan 2016, In: Journal of Nuclear Medicine. 57, 1, p. 96-102 7 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    36 Scopus citations

  • Lineage-specific STAT5 target gene activation in hematopoietic progenitor cells predicts the FLT3+-mediated leukemic phenotype

    Müller, T. A., Grundler, R., Istvanffy, R., Rudelius, M., Hennighausen, L., Illert, A. L. & Duyster, J., 1 Aug 2016, In: Leukemia. 30, 8, p. 1725-1733 9 p.

    Research output: Contribution to journal › Article › peer-review

    16 Scopus citations

  • Ptch2 loss drives myeloproliferation and myeloproliferative neoplasm progression

    Klein, C., Zwick, A., Kissel, S., Forster, C. U., Pfeifer, D., Follo, M., Illert, A. L., Decker, S., Benkler, T., Pahl, H., Oostendorp, R. A. J., Aumann, K., Duyster, J. & Dierks, C., 8 Feb 2016, In: Journal of Experimental Medicine. 213, 2, p. 273-290 18 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    32 Scopus citations
  • 2015

    F604S exchange in FIP1L1-PDGFRA enhances FIP1L1-PDGFRA protein stability via SHP-2 and SRC: A novel mode of kinase inhibitor resistance

    Gorantla, S. P., Zirlik, K., Reiter, A., Yu, C., Illert, A. L., Von Bubnoff, N. & Duyster, J., 7 Aug 2015, In: Leukemia. 29, 8, p. 1763-1770 8 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    12 Scopus citations

  • Grb10 is involved in BCR-ABL-positive leukemia in mice

    Illert, A. L., Albers, C., Kreutmair, S., Leischner, H., Peschel, C., Miething, C. & Duyster, J., 15 Apr 2015, In: Leukemia. 29, 4, p. 858-868 11 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    14 Scopus citations