Anette-Gabriele Ziegler

2025

EDENT1FI Master Protocol for screening of presymptomatic early-stage type 1 diabetes in children and adolescents

EDENT1FI consortium, 2 Jan 2025, In: BMJ Open. 15, 1, p. e088522

Research output: Contribution to journal › Article › peer-review

Open Access

2024

Caesarean section and risk of type 1 diabetes

Singh, T., Weiss, A., Vehik, K., Krischer, J., Rewers, M., Toppari, J., Lernmark, Å., Hagopian, W., Akolkar, B., Bonifacio, E., Ziegler, A. G. & Winkler, C., 2024, (Accepted/In press) In: Diabetologia.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

Consensus guidance for monitoring individuals with islet autoantibody-positive pre-stage 3 type 1 diabetes

Phillip, M., Achenbach, P., Addala, A., Albanese-O’Neill, A., Battelino, T., Bell, K. J., Besser, R. E. J., Bonifacio, E., Colhoun, H. M., Couper, J. J., Craig, M. E., Danne, T., de Beaufort, C., Dovc, K., Driscoll, K. A., Dutta, S., Ebekozien, O., Larsson, H. E., Feiten, D. J. & Frohnert, B. I. & 46 others, Gabbay, R. A., Gallagher, M. P., Greenbaum, C. J., Griffin, K. J., Hagopian, W., Haller, M. J., Hendrieckx, C., Hendriks, E., Holt, R. I. G., Hughes, L., Ismail, H. M., Jacobsen, L. M., Johnson, S. B., Kolb, L. E., Kordonouri, O., Lange, K., Lash, R. W., Lernmark, Å., Libman, I., Lundgren, M., Maahs, D. M., Marcovecchio, M. L., Mathieu, C., Miller, K. M., O’Donnell, H. K., Oron, T., Patil, S. P., Pop-Busui, R., Rewers, M. J., Rich, S. S., Schatz, D. A., Schulman-Rosenbaum, R., Simmons, K. M., Sims, E. K., Skyler, J. S., Smith, L. B., Speake, C., Steck, A. K., Thomas, N. P. B., Tonyushkina, K. N., Veijola, R., Wentworth, J. M., Wherrett, D. K., Wood, J. R., Ziegler, A. G. & DiMeglio, L. A., Sep 2024, In: Diabetologia. 67, 9, p. 1731-1759 29 p.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Scopus citations

Consensus Guidance for Monitoring Individuals With Islet Autoantibody–Positive Pre-Stage 3 Type 1 Diabetes

Phillip, M., Achenbach, P., Addala, A., Neill, A. A. O., Battelino, T., Bell, K. J., Besser, R. E. J., Bonifacio, E., Colhoun, H. M., Couper, J. J., Craig, M. E., Danne, T., de Beaufort, C., Dovc, K., Driscoll, K. A., Dutta, S., Ebekozien, O., Larsson, H. E., Feiten, D. J. & Frohnert, B. I. & 46 others, Gabbay, R. A., Gallagher, M. P., Greenbaum, C. J., Griffin, K. J., Hagopian, W., Haller, M. J., Hendrieckx, C., Hendriks, E., Holt, R. I. G., Hughes, L., Ismail, H. M., Jacobsen, L. M., Johnson, S. B., Kolb, L. E., Kordonouri, O., Lange, K., Lash, R. W., Lernmark, Å., Libman, I., Lundgren, M., Maahs, D. M., Marcovecchio, M. L., Mathieu, C., Miller, K. M., Donnell, H. K. O., Oron, T., Patil, S. P., Busui, R. P., Rewers, M. J., Rich, S. S., Schatz, D. A., Rosenbaum, R. S., Simmons, K. M., Sims, E. K., Skyler, J. S., Smith, L. B., Speake, C., Steck, A. K., Thomas, N. P. B., Tonyushkina, K. N., Veijola, R., Wentworth, J. M., Wherrett, D. K., Wood, J. R., Ziegler, A. G. & Dimeglio, L. A., Aug 2024, In: Diabetes Care. 47, 8, p. 1276-1298 23 p.

Research output: Contribution to journal › Article › peer-review

Open Access

9 Scopus citations

Data-Driven Phenotyping of Presymptomatic Type 1 Diabetes Using Longitudinal Autoantibody Profiles

T1DI Study Group , 1 Aug 2024, In: Diabetes Care. 47, 8, p. 1424-1431 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Definition, Klassifikation, Diagnostik und Differenzialdiagnostik des Diabetes mellitus: Update 2024

Schwarz, T., Niederau, C., Pleus, S., Tytko, A., Landgraf, R., Werner, C., Müller-Wieland, D., Müller, U. A., Freckmann, G., Schleicher, E., Nauck, M., Petersmann, A., Ziegler, A. G. & Heinemann, L., 21 Nov 2024, In: Diabetologie und Stoffwechsel. 19, p. S125-S137

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Gene expression profiles in placenta and their association with anesthesia, delivery mode and maternal diabetes

Aljani, B., Garbe, A. I., Sedlmeier, E. M., Lickert, R., Rost, F., Ziegler, A. G., Bonifacio, E. & Eugster, A., Dec 2024, In: Placenta. 158, p. 126-135 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Infection episodes and islet autoantibodies in children at increased risk for type 1 diabetes before and during the COVID-19 pandemic

for the GPPAD Study Group, 2024, (Accepted/In press) In: Infection.

Research output: Contribution to journal › Article › peer-review

Open Access

Progression From Presymptomatic to Clinical Type 1 Diabetes After COVID-19 Infection

Fr1da Study Group, 13 Aug 2024, In: JAMA - Journal of the American Medical Association. 332, 6, p. 501-502 2 p.

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Risk of celiac disease autoimmunity is modified by interactions between CD247 and environmental exposures

Colorado Clinical Center, Previously, TEDDY Study Group, Other contributors, Repository, HLA Reference Laboratory, Genetics Laboratory, Autoantibody Reference Laboratories, Project Scientist, Data Coordinating Center, Pennsylvania Satellite Center, Washington Clinical Center, Sweden Clinical Center, Germany Clinical Center, Georgia/Florida Clinical Center & Finland Clinical Center, Dec 2024, In: Scientific Reports. 14, 1, 25463.

Research output: Contribution to journal › Article › peer-review

Open Access

The Influence of Pubertal Development on Autoantibody Appearance and Progression to Type 1 Diabetes in the TEDDY Study

Warncke, K., Tamura, R., Schatz, D. A., Veijola, R., Steck, A. K., Akolkar, B., Hagopian, W., Krischer, J. P., Lernmark, Å., Rewers, M. J., Toppari, J., McIndoe, R., Ziegler, A. G., Vehik, K., Haller, M. J. & Elding Larsson, H., 1 Jul 2024, In: Journal of the Endocrine Society. 8, 7, bvae103.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

2023

Der Beginn einer neuen Therapieära: Ein Gastkommentar

Translated title of the contribution: The beginning of a new era in therapy: A guest commentaryZiegler, A. G. & Teichgräber, F. J., 2023, In: Deutsche Apotheker Zeitung. 163, 6, 27.

Research output: Contribution to journal › Article › peer-review

Früherkennung von Typ-1-Diabetes durch Inselautoantikörper-Screening - ein Positionspapier der Fr1da ^Plex -Projektleiter und -Schulungszentren, des BVKJ Bayern und PaedNetz Bayern eV.

Achenbach, P., Berner, R., Bonifacio, E., Brämswig, S., Braig, S., Dunstheimer, D., Ermer, U., Ewald, D., Gemulla, G., Hauer, J., Haupt, F., Haus, G., Hubmann, M., Hummel, S., Kandler, M., Kordonouri, O., Lange, K., Laub, O., Lorrmann, A. & Nellen-Hellmuth, N. & 7 others, Sindichakis, M., Von Dem Berge, T., Warncke, K., Weber, L., Winkler, C., Wintermeyer, P. & Ziegler, A. G., 2023, (Accepted/In press) In: Gesundheitswesen.

Research output: Contribution to journal › Article › peer-review

Open Access

Triggert SARS-CoV-2 die Entwicklung von Typ-1-Diabetes?

Translated title of the contribution: Does SARS-CoV-2 trigger the development of type 1 diabetes? One-year-old children with genetic risk are particularly vulnerableZiegler, A. G., Schwenker, L. & Ochel, P., 2023, In: Deutsche Apotheker Zeitung. 2023, 46

Research output: Contribution to journal › Article › peer-review

2022

Durchbruch in der Immuntherapie des Typ-1-Diabetes

Translated title of the contribution: Breakthrough in the immunotherapy of type 1 diabetesZiegler, A. G., 1 May 2022, In: Diabetes Aktuell. 20, 3, p. 114 1 p.

Research output: Contribution to journal › Article › peer-review

INNODIA Master Protocol for the evaluation of investigational medicinal products in children, adolescents and adults with newly diagnosed type 1 diabetes

on behalf of the INNODIA consortium, Dec 2022, In: Trials. 23, 1, 414.

Research output: Contribution to journal › Article › peer-review

Open Access

19 Scopus citations

Integration of Infant Metabolite, Genetic, and Islet Autoimmunity Signatures to Predict Type 1 Diabetes by Age 6 Years

Webb-Robertson, B. J. M., Nakayasu, E. S., Frohnert, B. I., Bramer, L. M., Akers, S. M., Norris, J. M., Vehik, K., Ziegler, A. G., Metz, T. O., Rich, S. S. & Rewers, M. J., 1 Aug 2022, In: Journal of Clinical Endocrinology and Metabolism. 107, 8, p. 2329-2338 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

11 Scopus citations

Maternal haemoglobin levels in pregnancy and child DNA methylation: a study in the pregnancy and childhood epigenetics consortium

Ronkainen, J., Heiskala, A., Vehmeijer, F. O. L., Lowry, E., Caramaschi, D., Estrada Gutierrez, G., Heiss, J. A., Hummel, N., Keikkala, E., Kvist, T., Kupsco, A., Melton, P. E., Pesce, G., Soomro, M. H., Vives-Usano, M., Baiz, N., Binder, E., Czamara, D., Guxens, M. & Mustaniemi, S. & 17 others, London, S. J., Rauschert, S., Vääräsmäki, M., Vrijheid, M., Ziegler, A. G., Annesi-Maesano, I., Bustamante, M., Huang, R. C., Hummel, S., Just, A. C., Kajantie, E., Lahti, J., Lawlor, D., Räikkönen, K., Järvelin, M. R., Felix, J. F. & Sebert, S., 2022, In: Epigenetics. 17, 1, p. 19-31 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

Progression likelihood score identifies substages of presymptomatic type 1 diabetes in childhood public health screening

for the Fr1da-study group, Dec 2022, In: Diabetologia. 65, 12, p. 2121-2131 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

27 Scopus citations

Telomere length is not a main factor for the development of islet autoimmunity and type 1 diabetes in the TEDDY study

Genetics Laboratory, HLA Reference Laboratory, Repository, the TEDDY Study Group, Colorado Clinical Center, Finland Clinical Center, Georgia/Florida Clinical Center, Germany Clinical Center, Sweden Clinical Center, Washington Clinical Center, Pennsylvania Satellite Center, Data Coordinating Center, Past staff & Autoantibody Reference Laboratories, Dec 2022, In: Scientific Reports. 12, 1, 4516.

Research output: Contribution to journal › Article › peer-review

Open Access

9 Scopus citations

2021

First-appearing islet autoantibodies for type 1 diabetes in young children: maternal life events during pregnancy and the child’s genetic risk

the TEDDY Study Group, Mar 2021, In: Diabetologia. 64, 3, p. 591-602 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Scopus citations

Oral insulin immunotherapy in children at risk for type 1 diabetes in a randomised controlled trial

Assfalg, R., Knoop, J., Hoffman, K. L., Pfirrmann, M., Zapardiel-Gonzalo, J. M., Hofelich, A., Eugster, A., Weigelt, M., Matzke, C., Reinhardt, J., Fuchs, Y., Bunk, M., Weiss, A., Hippich, M., Halfter, K., Hauck, S. M., Hasford, J., Petrosino, J. F., Achenbach, P. & Bonifacio, E. & 1 others, Ziegler, A. G., May 2021, In: Diabetologia. 64, 5, p. 1079-1092 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

34 Scopus citations

Shortening the paths to type 1 diabetes mellitus prevention

Ziegler, A. G. & Bonifacio, E., Feb 2021, In: Nature Reviews Endocrinology. 17, 2, p. 73-74 2 p.

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Simplifying prediction of disease progression in pre-symptomatic type 1 diabetes using a single blood sample

Bediaga, N. G., Li-Wai-Suen, C. S. N., Haller, M. J., Gitelman, S. E., Evans-Molina, C., Gottlieb, P. A., Hippich, M., Ziegler, A. G., Lernmark, A., DiMeglio, L. A., Wherrett, D. K., Colman, P. G., Harrison, L. C. & Wentworth, J. M., Nov 2021, In: Diabetologia. 64, 11, p. 2432-2444 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

10 Scopus citations

Teplizumab improves and stabilizes beta cell function in antibody-positive high-risk individuals

Type 1 Diabetes TrialNet Study Group, 3 Mar 2021, In: Science Translational Medicine. 13, 583, eabc8980.

Research output: Contribution to journal › Article › peer-review

Open Access

185 Scopus citations

2020

A combined risk score enhances prediction of type 1 diabetes among susceptible children

Committees, 1 Aug 2020, In: Nature Medicine. 26, 8, p. 1247-1255 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

93 Scopus citations

Autoantibody-negative insulin-dependent diabetes mellitus after SARS-CoV-2 infection: a case report

Hollstein, T., Schulte, D. M., Schulz, J., Glück, A., Ziegler, A. G., Bonifacio, E., Wendorff, M., Franke, A., Schreiber, S., Bornstein, S. R. & Laudes, M., 1 Oct 2020, In: Nature Metabolism. 2, 10, p. 1021-1024 4 p.

Research output: Contribution to journal › Article › peer-review

Open Access

133 Scopus citations

Circulating unmethylated CHTOP and INS DNA fragments provide evidence of possible islet cell death in youth with obesity and diabetes

Syed, F., Tersey, S. A., Turatsinze, J. V., Felton, J. L., Kang, N. J., Nelson, J. B., Sims, E. K., Defrance, M., Bizet, M., Fuks, F., Cnop, M., Bugliani, M., Marchetti, P., Ziegler, A. G., Bonifacio, E., Webb-Robertson, B. J., Balamurugan, A. N., Evans-Molina, C., Eizirik, D. L. & Mather, K. J. & 2 others, Arslanian, S. & Mirmira, R. G., 31 Jul 2020, In: Clinical Epigenetics. 12, 1, 116.

Research output: Contribution to journal › Article › peer-review

Open Access

16 Scopus citations

DIABETES MELLITUS Typ-1-Diabetes aufhalten Neue Ansätze in der Prävention der Autoimmunerkrankung

Translated title of the contribution: Stopping type 1 diabetes: New approaches in the prevention of the autoimmune diseaseZiegler, A. G., 2020, In: Deutsche Apotheker Zeitung. 6, A25.

Research output: Contribution to journal › Article › peer-review

Distinct growth phases in early life associated with the risk of type 1 diabetes: The teddy study

TEDDY Study Group, 1 Mar 2020, In: Diabetes Care. 43, 3, p. 556-562 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

33 Scopus citations

Hierarchical order of distinct autoantibody spreading and progression to type 1 diabetes in the Teddy study

TEDDY Study Group, Sep 2020, In: Diabetes Care. 43, 9, p. 2066-2073 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

57 Scopus citations

Intergenerational metabolomic analysis of mothers with a history of gestational diabetes mellitus and their offspring

Ott, R., Pawlow, X., Weiß, A., Hofelich, A., Herbst, M., Hummel, N., Prehn, C., Adamski, J., Römisch-Margl, W., Kastenmüller, G., Ziegler, A. G. & Hummel, S., 2 Dec 2020, In: International Journal of Molecular Sciences. 21, 24, p. 1-23 23 p., 9647.

Research output: Contribution to journal › Article › peer-review

Open Access

9 Scopus citations

LifeTime and improving European healthcare through cell-based interceptive medicine

LifeTime Community Working Groups, 19 Nov 2020, In: Nature. 587, 7834, p. 377-386 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

105 Scopus citations

Longitudinal metabolome-wide signals prior to the appearance of a first islet autoantibody in children participating in the TEDDY study

Li, Q., Parikh, H., Butterworth, M. D., Lernmark, Å., Hagopian, W., Rewers, M., She, J. X., Toppari, J., Ziegler, A. G., Akolkar, B., Fiehn, O., Fan, S., Krischer, J. P., Barbour, A., Bautista, K., Baxter, J., Felipe-Morales, D., Driscoll, K., Frohnert, B. I. & Stahl, M. & 233 others, Gesualdo, P., Hoffman, M., Karban, R., Liu, E., Norris, J., Peacock, S., Shorrosh, H., Steck, A., Stern, M., Villegas, E., Waugh, K., Toppari, J., Simell, O. G., Adamsson, A., Ahonen, S., Åkerlund, M., Hakola, L., Hekkala, A., Holappa, H., Hyöty, H., Ikonen, A., Ilonen, J., Jäminki, S., Jokipuu, S., Karlsson, L., Kero, J., Kähönen, M., Knip, M., Koivikko, M. L., Koskinen, M., Koreasalo, M., Kurppa, K., Kytölä, J., Latva-Aho, T., Lindfors, K., Lönnrot, M., Mäntymäki, E., Mattila, M., Miettinen, M., Multasuo, K., Mykkänen, T., Niininen, T., Niinistö, S., Nyblom, M., Oikarinen, S., Ollikainen, P., Othmani, Z., Pohjola, S., Rajala, P., Rautanen, J., Riikonen, A., Riski, E., Pekkola, M., Romo, M., Ruohonen, S., Simell, S., Sjöberg, M., Stenius, A., Tossavainen, P., Vähä-Mäkilä, M., Vainionpää, S., Varjonen, E., Veijola, R., Viinikangas, I., Virtanen, S. M., She, J. X., Schatz, D., Hopkins, D., Steed, L., Bryant, J., Silvis, K., Haller, M., Gardiner, M., McIndoe, R., Sharma, A., Anderson, S. W., Jacobsen, L., Marks, J., Towe, P. D., Bonifacio, E., Gavrisan, A., Gezginci, C., Heublein, A., Hoffmann, V., Hummel, S., Keimer, A., Knopff, A., Koch, C., Koletzko, S., Ramminger, C., Roth, R., Scholz, M., Stock, J., Warncke, K., Wendel, L., Winkler, C., Agardh, D., Aronsson, C. A., Ask, M., Bennet, R., Cilio, C., Engqvist, H., Ericson-Hallström, E., Fors, A., Fransson, L., Gard, T., Hansen, M., Jisser, H., Johansen, F., Jonsdottir, B., Jovic, S., Larsson, H. E., Lindström, M., Lundgren, M., Maziarz, M., Månsson-Martinez, M., Markan, M., Melin, J., Mestan, Z., Nilsson, C., Ottosson, K., Rahmati, K., Ramelius, A., Salami, F., Sjöberg, A., Sjöberg, B., Svensson, M., Törn, C., Wallin, A., Wimar, Å., Åberg, S., Hagopian, W. A., Killian, M., Crouch, C. C., Skidmore, J., Chavoshi, M., Hervey, R., Lyons, R., Meyer, A., Mulenga, D., Radtke, J., Romancik, M., Schmitt, D., Zink, S., Becker, D., Franciscus, M., Smith, M. E. D. E., Daftary, A., Klein, M. B., Yates, C., Krischer, J. P., Austin-Gonzalez, S., Avendano, M., Baethke, S., Brown, R., Burkhardt, B., Butterworth, M., Clasen, J., Cuthbertson, D., Dankyi, S., Eberhard, C., Fiske, S., Garmeson, J., Gowda, V., Heyman, K., Hsiao, B., Karges, C., Laras, F. P., Lee, H. S., Li, Q., Liu, S., Liu, X., Lynch, K., Maguire, C., Malloy, J., McCarthy, C., Merrell, A., Parikh, H., Quigley, R., Remedios, C., Shaffer, C., Smith, L., Smith, S., Sulman, N., Tamura, R., Tewey, D., Toth, M., Uusitalo, U., Vehik, K., Vijayakandipan, P., Wood, K., Yang, J., Abbondondolo, M., Ballard, L., Hadley, D., McLeod, W., Meulemans, S., Akolkar, B., Bourcier, K., Briese, T., Johnson, S. B., Triplett, E., Yu, L., Miao, D., Bingley, P., Williams, A., Chandler, K., Ball, O., Kelland, I., Grace, S., Erlich, H., Mack, S. J., Fear, A. L., Fiehn, O., Wikoff, B., Defelice, B., Grapov, D., Kind, T., Palazoglu, M., Valdiviez, L., Wancewicz, B., Wohlgemuth, G., Wong, J., Rich, S. S., Chen, W. M., Onengut-Gumuscu, S., Farber, E., Pickin, R. R., Davis, J., Davis, J., Gallo, D., Bonnie, J. & Campolieto, P., 1 Mar 2020, In: Diabetes. 69, 3, p. 465-476 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

31 Scopus citations

Maternal type 1 diabetes reduces autoantigen-responsive CD4¹ T cells in offspring

Knoop, J., Eugster, A., Gavrisan, A., Lickert, R., Sedlmeier, E. M., Dietz, S., Lindner, A., Warncke, K., Hummel, N., Ziegler, A. G. & Bonifacio, E., 1 Apr 2020, In: Diabetes. 69, 4, p. 661-669 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

11 Scopus citations

Metagenomics of the faecal virome indicate a cumulative effect of enterovirus and gluten amount on the risk of coeliac disease autoimmunity in genetically at risk children: The TEDDY study

Lindfors, K., Lin, J., Lee, H. S., Hyöty, H., Nykter, M., Kurppa, K., Liu, E., Koletzko, S., Rewers, M., Hagopian, W., Toppari, J., Ziegler, A. G., Akolkar, B., Krischer, J. P., Petrosino, J. F., Lloyd, R. E. & Agardh, D., 1 Aug 2020, In: Gut. 69, 8, p. 1416-1422 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

93 Scopus citations

Plasma ascorbic acid and the risk of islet autoimmunity and type 1 diabetes: the TEDDY study

for the TEDDY Study Group, 1 Feb 2020, In: Diabetologia. 63, 2, p. 278-286 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

26 Scopus citations

Randomized 52-week phase 2 trial of albiglutide versus placebo in adult patients with newly diagnosed type 1 diabetes

Pozzilli, P., Bosi, E., Cirkel, D., Harris, J., Leech, N., Tinahones, F. J., Vantyghem, M. C., Vlasakakis, G., Ziegler, A. G. & Janmohamed, S., 1 Jun 2020, In: Journal of Clinical Endocrinology and Metabolism. 105, 6

Research output: Contribution to journal › Article › peer-review

Open Access

22 Scopus citations

Yield of a Public Health Screening of Children for Islet Autoantibodies in Bavaria, Germany

Ziegler, A. G., Kick, K., Bonifacio, E., Haupt, F., Hippich, M., Dunstheimer, D., Lang, M., Laub, O., Warncke, K., Lange, K., Assfalg, R., Jolink, M., Winkler, C. & Achenbach, P., 28 Jan 2020, In: JAMA - Journal of the American Medical Association. 323, 4, p. 339-351 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

169 Scopus citations

2019

Age, HLA, and sex define a marked risk of organ-specific autoimmunity in first-degree relatives of patients with type 1 diabetes

Winkler, C., Jolink, M., Knopff, A., Kwarteng, N. A., Achenbach, P., Bonifacio,, E. & Ziegler, A. G., 1 Sep 2019, In: Diabetes Care. 42, 9, p. 1684-1691 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

14 Scopus citations

An anti-CD3 antibody, teplizumab, in relatives at risk for type 1 diabetes

Herold, K. C., Bundy, B. N., Alice Long, S., Bluestone, J. A., DiMeglio, L. A., Dufort, M. J., Gitelman, S. E., Gottlieb, P. A., Krischer, J. P., Linsley, P. S., Marks, J. B., Moore, W., Moran, A., Rodriguez, H., Russell, W. E., Schatz, D., Skyler, J. S., Tsalikian, E., Wherrett, D. K. & Ziegler, A. G. & 1 others, Greenbaum, C. J., 15 Aug 2019, In: New England Journal of Medicine. 381, 7, p. 603-613 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

671 Scopus citations

Association of Dendritic Cell Signatures With Autoimmune Inflammation Revealed by Single-Cell Profiling

Ashton, M. P., Eugster, A., Dietz, S., Loebel, D., Lindner, A., Kuehn, D., Taranko, A. E., Heschel, B., Gavrisan, A., Ziegler, A. G., Aringer, M. & Bonifacio, E., May 2019, In: Arthritis and Rheumatology. 71, 5, p. 817-828 12 p.

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Association of gluten intake during the first 5 years of life with incidence of celiac disease autoimmunity and celiac disease among children at increased risk

Andrén Aronsson, C., Lee, H. S., Hård Af Segerstad, E. M., Uusitalo, U., Yang, J., Koletzko, S., Liu, E., Kurppa, K., Bingley, P. J., Toppari, J., Ziegler, A. G., She, J. X., Hagopian, W. A., Rewers, M., Akolkar, B., Krischer, J. P., Virtanen, S. M., Norris, J. M. & Agardh, D., 13 Aug 2019, In: JAMA - Journal of the American Medical Association. 322, 6, p. 514-523 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

110 Scopus citations

Blood draws up to 3% of blood volume in clinical trials are safe in children

Peplow, C., Assfalg, R., Beyerlein, A., Hasford, J., Bonifacio, E. & Ziegler, A. G., May 2019, In: Acta Paediatrica, International Journal of Paediatrics. 108, 5, p. 940-944 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

14 Scopus citations

Common patterns of gene regulation associated with Cesarean section and the development of islet autoimmunity – indications of immune cell activation

Laimighofer, M., Lickert, R., Fuerst, R., Theis, F. J., Winkler, C., Bonifacio, E., Ziegler, A. G. & Krumsiek, J., 1 Dec 2019, In: Scientific Reports. 9, 1, 6250.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Scopus citations

Cytoplasmic ends of tetraspanin 7 harbour epitopes recognised by autoantibodies in type 1 diabetes

Eugster, A., Kraus, G., Lidzba, V., Müller, D., Jolink, M., Ziegler, A. G. & Bonifacio, E., 1 May 2019, In: Diabetologia. 62, 5, p. 805-810 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

7 Scopus citations

Early probiotic supplementation and the risk of celiac disease in children at genetic risk

TEDDY Study Group, Aug 2019, In: Nutrients. 11, 8, 1790.

Research output: Contribution to journal › Article › peer-review

Open Access

25 Scopus citations

Feasibility and organization of a population-based screening for pre-symptomatic type 1 diabetes in children — evaluation of the Fr1da study

Kick, K., Hoffmann, V. S., Lange, K., Lang, M., Laub, O., Bechtold-Dalla Pozza, S., Böcker, D., Braig, S., Dietz, B., Dunstheimer, D., Eber, S., Ermer, U., Gavazzeni, A., Gerstl, E. M., Götz, M., Huhn, F., Kuhnle-Krahl, U., Landendörfer, W., Leipold, G. & Leppik, K. H. & 12 others, Müller, H., Müller, I., Nellen-Hellmuth, N., Ockert, C., Renner, C., Sindichakis, M., Tretter, S., Warncke, K., Winkler, C., Zeller, S., Achenbach, P. & Ziegler, A. G., 1 Oct 2019, In: Journal of Public Health (Germany). 27, 5, p. 553-560 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

Genetic contribution to the divergence in type 1 diabetes risk between children from the general population and children from affected families

the TEDDY Study Group, 1 Apr 2019, In: Diabetes. 68, 4, p. 847-857 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

25 Scopus citations

Identification of infants with increased type 1 diabetes genetic risk for enrollment into Primary Prevention Trials—GPPAD-02 study design and first results

the GPPAD Study Group, 2019, In: Pediatric Diabetes. 20, 6, p. 720-727 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

38 Scopus citations

Anette-Gabriele Ziegler

Research output

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