Institute of Molecular Oncology and Functional Genomics

2025

A decision point between transdifferentiation and programmed cell death priming controls KRAS-dependent pancreatic cancer development

Schneider, A. T., Koppe, C., Crouchet, E., Papargyriou, A., Singer, M. T., Büttner, V., Keysberg, L., Szydlowska, M., Jühling, F., Moehlin, J., Chen, M. C., Leone, V., Mueller, S., Neuß, T., Castoldi, M., Lesina, M., Bergmann, F., Hackert, T., Steiger, K. & Knoefel, W. T. & 18 others, Zaufel, A., Kather, J. N., Esposito, I., Gaida, M. M., Ghallab, A., Hengstler, J. G., Einwächter, H., Unger, K., Algül, H., Gassler, N., Schmid, R. M., Rad, R., Baumert, T. F., Reichert, M., Heikenwalder, M., Kondylis, V., Vucur, M. & Luedde, T., Dec 2025, In: Nature Communications. 16, 1, 1765.

Research output: Contribution to journal › Article › peer-review

Open Access

Autoimmunity promotes chronic lymphocytic leukemia progression in an indolent disease model

Pfeuffer, L., Siegert, V., Trozzo, R., Steiger, K., Rad, R., Ruland, J. & Buchner, M., 3 Feb 2025, In: Scientific Reports. 15, 1, p. 4117 1 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Genomic and phenotypic stability of fusion-driven pediatric sarcoma cell lines

Kasan, M., Geyer, F. H., Siebenlist, J., Sill, M., Öllinger, R., Faehling, T., de Álava, E., Surdez, D., Dirksen, U., Oehme, I., Scotlandi, K., Delattre, O., Müller-Nurasyid, M., Rad, R., Strauch, K., Grünewald, T. G. P. & Cidre-Aranaz, F., Dec 2025, In: Nature Communications. 16, 1, 380.

Research output: Contribution to journal › Article › peer-review

Open Access

Two-layered immune escape in AML is overcome by Fcγ receptor activation and inhibition of PGE₂ signaling in NK cells

Rothfuß, C., Baumann, T., Donakonda, S., Brauchle, B., Marcinek, A., Urban, C., Mergner, J., Pedde, A. M., Hirschberger, A., Krupka, C., Neumann, A. S., Hänel, G., Merten, C., Öllinger, R., Hecker, J. S., Bauer, T., Schmid, C., Götze, K. S., Altomonte, J. & Bücklein, V. & 10 others, Jacobs, R., Rad, R., Dawid, C., Simeoni, L., Schraven, B., Pichlmair, A., Subklewe, M., Knolle, P. A., Böttcher, J. P. & Höchst, B., 2025, (Accepted/In press) In: Blood.

Research output: Contribution to journal › Article › peer-review

Open Access

2024

A liver immune rheostat regulates CD8 T cell immunity in chronic HBV infection

Bosch, M., Kallin, N., Donakonda, S., Zhang, J. D., Wintersteller, H., Hegenbarth, S., Heim, K., Ramirez, C., Fürst, A., Lattouf, E. I., Feuerherd, M., Chattopadhyay, S., Kumpesa, N., Griesser, V., Hoflack, J. C., Siebourg-Polster, J., Mogler, C., Swadling, L., Pallett, L. J. & Meiser, P. & 36 others, Manske, K., de Almeida, G. P., Kosinska, A. D., Sandu, I., Schneider, A., Steinbacher, V., Teng, Y., Schnabel, J., Theis, F., Gehring, A. J., Boonstra, A., Janssen, H. L. A., Vandenbosch, M., Cuypers, E., Öllinger, R., Engleitner, T., Rad, R., Steiger, K., Oxenius, A., Lo, W. L., Klepsch, V., Baier, G., Holzmann, B., Maini, M. K., Heeren, R., Murray, P. J., Thimme, R., Herrmann, C., Protzer, U., Böttcher, J. P., Zehn, D., Wohlleber, D., Lauer, G. M., Hofmann, M., Luangsay, S. & Knolle, P. A., 25 Jul 2024, In: Nature. 631, 8022, p. 867-875 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

11 Scopus citations

A Novel AMPK Inhibitor Sensitizes Pancreatic Cancer Cells to Ferroptosis Induction

Schneider, C., Hilbert, J., Genevaux, F., Höfer, S., Krauß, L., Schicktanz, F., Contreras, C. T., Jansari, S., Papargyriou, A., Richter, T., Alfayomy, A. M., Falcomatà, C., Schneeweis, C., Orben, F., Öllinger, R., Wegwitz, F., Boshnakovska, A., Rehling, P., Müller, D. & Ströbel, P. & 13 others, Ellenrieder, V., Conradi, L., Hessmann, E., Ghadimi, M., Grade, M., Wirth, M., Steiger, K., Rad, R., Kuster, B., Sippl, W., Reichert, M., Saur, D. & Schneider, G., 2024, (Accepted/In press) In: Advanced Science.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Scopus citations

A ONECUT1 regulatory, non-coding region in pancreatic development and diabetes

Merz, S., Senée, V., Philippi, A., Oswald, F., Shaigan, M., Führer, M., Drewes, C., Allgöwer, C., Öllinger, R., Heni, M., Boland, A., Deleuze, J. F., Birkhofer, F., Gusmao, E. G., Wagner, M., Hohwieler, M., Breunig, M., Rad, R., Siebert, R. & Messerer, D. A. C. & 5 others, Costa, I. G., Alvarez, F., Julier, C., Kleger, A. & Heller, S., 26 Nov 2024, In: Cell Reports. 43, 11, 114853.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

B-cell intrinsic RANK signaling cooperates with TCL1 to induce lineage-dependent B-cell transformation

Pfeuffer, L., Siegert, V., Frede, J., Rieger, L., Trozzo, R., de Andrade Krätzig, N., Ring, S., Sarhadi, S., Beck, N., Niedermeier, S., Abril-Gil, M., Elbahloul, M., Remke, M., Steiger, K., Eichner, R., Jellusova, J., Rad, R., Bassermann, F., Winter, C. & Ruland, J. & 1 others, Buchner, M., Dec 2024, In: Blood Cancer Journal. 14, 1, 151.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

B cells orchestrate tolerance to the neuromyelitis optica autoantigen AQP4

Afzali, A. M., Nirschl, L., Sie, C., Pfaller, M., Ulianov, O., Hassler, T., Federle, C., Petrozziello, E., Kalluri, S. R., Chen, H. H., Tyystjärvi, S., Muschaweckh, A., Lammens, K., Delbridge, C., Büttner, A., Steiger, K., Seyhan, G., Ottersen, O. P., Öllinger, R. & Rad, R. & 16 others, Jarosch, S., Straub, A., Mühlbauer, A., Grassmann, S., Hemmer, B., Böttcher, J. P., Wagner, I., Kreutzfeldt, M., Merkler, D., Pardàs, I. B., Schmidt Supprian, M., Buchholz, V. R., Heink, S., Busch, D. H., Klein, L. & Korn, T., 14 Mar 2024, In: Nature. 627, 8003, p. 407-415 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

15 Scopus citations

CDK4/6 inhibition initiates cell cycle arrest by nuclear translocation of RB and induces a multistep molecular response

Hong, T., Hogger, A. C., Wang, D., Pan, Q., Gansel, J., Engleitner, T., Öllinger, R., Gschwend, J. E., Rad, R. & Nawroth, R., Dec 2024, In: Cell Death Discovery. 10, 1, 453.

Research output: Contribution to journal › Article › peer-review

Open Access

Genome-scale pan-cancer interrogation of lncRNA dependencies using CasRx

Montero, J. J., Trozzo, R., Sugden, M., Öllinger, R., Belka, A., Zhigalova, E., Waetzig, P., Engleitner, T., Schmidt-Supprian, M., Saur, D. & Rad, R., Apr 2024, In: Nature Methods. 21, 4, p. 584-596 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

7 Scopus citations

HBV-related HCC development in mice is STAT3 dependent and indicates an oncogenic effect of HBx

Ringelhan, M., Schuehle, S., van de Klundert, M., Kotsiliti, E., Plissonnier, M. L., Faure-Dupuy, S., Riedl, T., Lange, S., Wisskirchen, K., Thiele, F., Cheng, C. C., Yuan, D., Leone, V., Schmidt, R., Hünergard, J., Geisler, F., Unger, K., Algül, H., Schmid, R. M. & Rad, R. & 4 others, Wedemeyer, H., Levrero, M., Protzer, U. & Heikenwalder, M., Oct 2024, In: JHEP Reports. 6, 10, 101128.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

Heterogeneity-driven phenotypic plasticity and treatment response in branched-organoid models of pancreatic ductal adenocarcinoma

Papargyriou, A., Najajreh, M., Cook, D. P., Maurer, C. H., Bärthel, S., Messal, H. A., Ravichandran, S. K., Richter, T., Knolle, M., Metzler, T., Shastri, A. R., Öllinger, R., Jasper, J., Schmidleitner, L., Wang, S., Schneeweis, C., Ishikawa-Ankerhold, H., Engleitner, T., Mataite, L. & Semina, M. & 24 others, Trabulssi, H., Lange, S., Ravichandra, A., Schuster, M., Mueller, S., Peschke, K., Schäfer, A., Dobiasch, S., Combs, S. E., Schmid, R. M., Bausch, A. R., Braren, R., Heid, I., Scheel, C. H., Schneider, G., Zeigerer, A., Luecken, M. D., Steiger, K., Kaissis, G., van Rheenen, J., Theis, F. J., Saur, D., Rad, R. & Reichert, M., 2024, (Accepted/In press) In: Nature Biomedical Engineering. 102858.

Research output: Contribution to journal › Article › peer-review

Open Access

High Concordance of Different Assays in the Determination of Homologous Recombination Deficiency–Associated Genomic Instability in Ovarian Cancer

on behalf of the German HRD assay Harmonization Consortium, 1 Mar 2024, In: JCO Precision Oncology. 8, e2300348.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Scopus citations

High-resolution profile of neoantigen-specific TCR activation links moderate stimulation to increased resilience of engineered TCR-T cells

Füchsl, F., Untch, J., Kavaka, V., Zuleger, G., Braun, S., Schwanzer, A., Jarosch, S., Vogelsang, C., de Andrade Krätzig, N., Gosmann, D., Öllinger, R., Giansanti, P., Hiltensperger, M., Rad, R., Busch, D. H., Beltrán, E., Bräunlein, E. & Krackhardt, A. M., Dec 2024, In: Nature Communications. 15, 1, 10520.

Research output: Contribution to journal › Article › peer-review

Open Access

Multi-omics characterization of the monkeypox virus infection

Huang, Y., Bergant, V., Grass, V., Emslander, Q., Hamad, M. S., Hubel, P., Mergner, J., Piras, A., Krey, K., Henrici, A., Öllinger, R., Tesfamariam, Y. M., Dalla Rosa, I., Bunse, T., Sutter, G., Ebert, G., Schmidt, F. I., Way, M., Rad, R. & Bowie, A. G. & 2 others, Protzer, U. & Pichlmair, A., Dec 2024, In: Nature Communications. 15, 1, 6778.

Research output: Contribution to journal › Article › peer-review

Open Access

9 Scopus citations

Mutual regulation of CD4⁺ T cells and intravascular fibrin in infections

Mueller, T. T., Pilartz, M., Thakur, M., LangHeinrich, T., Luo, J., Block, R., Hoeflinger, J. K. L., Meister, S., Karaj, F., Perez, L. G., Öllinger, R., Engleitner, T., Thoss, J., Voelkl, M., Tersteeg, C., Koedel, U., Kohlmaier, A. Z., Teupser, D., Wygrecka, M. & Ye, H. & 12 others, Preissner, K. T., Radbruch, H., Elezkurtaj, S., Mack, M., Von Hundelshausen, P., Weber, C., Massberg, S., Schulz, C., Rad, R., Huber, S., Ishikawa-Ankerhold, H. & Engelmann, B., Aug 2024, In: Haematologica. 109, 8, p. 2487-2499 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Preclinical efficacy of carfilzomib in BRAF-mutant colorectal cancer models

Maione, F., Oddo, D., Galvagno, F., Falcomatà, C., Pandini, M., Macagno, M., Pessei, V., Barault, L., Gigliotti, C., Mira, A., Corti, G., Lamba, S., Riganti, C., Castella, B., Massaia, M., Rad, R., Saur, D., Bardelli, A. & Di Nicolantonio, F., Jun 2024, In: Molecular Oncology. 18, 6, p. 1552-1570 19 p.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

The Caspase-Activated DNase drives inflammation and contributes to defense against viral infection

Moeed, A., Thilmany, N., Beck, F., Puthussery, B. K., Ortmann, N., Haimovici, A., Badr, M. T., Haghighi, E. B., Boerries, M., Öllinger, R., Rad, R., Kirschnek, S., Gentle, I. E., Donakonda, S., Petric, P. P., Hummel, J. F., Pfaffendorf, E., Zanetta, P., Schell, C. & Schwemmle, M. & 2 others, Weber, A. & Häcker, G., Jul 2024, In: Cell Death and Differentiation. 31, 7, p. 924-937 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

Tissue-colonizing disseminated tumor cells secrete prostaglandin E2 to promote NK cell dysfunction and evade anti-metastatic immunity

Pedde, A. M., Kim, H., Donakonda, S., Baumann, T., Bayerl, F., Meiser, P., Hirschberger, A., Klement, C., Grassmann, S., Öllinger, R., Hüser, N., Hartmann, D., Laschinger, M., Trapani, J. A., Zippelius, A., Bald, T., Wiedemann, G. M., Rad, R., Sun, J. C. & Höchst, B. & 1 others, Böttcher, J. P., 26 Nov 2024, In: Cell Reports. 43, 11, 114855.

Research output: Contribution to journal › Article › peer-review

Open Access

2023

Actionable loss of SLF2 drives B-cell lymphomagenesis and impairs the DNA damage response

Zhang, L., Wirth, M., Patra, U., Stroh, J., Isaakidis, K., Rieger, L., Kossatz, S., Milanovic, M., Zang, C., Demel, U., Keiten-Schmitz, J., Wagner, K., Steiger, K., Rad, R., Bassermann, F., Müller, S., Keller, U. & Schick, M., 11 Sep 2023, In: EMBO Molecular Medicine. 15, 9, e16431.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

An integrated cellular and molecular model of gastric neuroendocrine cancer evolution highlights therapeutic targets

Griger, J., Widholz, S. A., Jesinghaus, M., de Andrade Krätzig, N., Lange, S., Engleitner, T., Montero, J. J., Zhigalova, E., Öllinger, R., Suresh, V., Winkler, W., Lier, S., Baranov, O., Trozzo, R., Ben Khaled, N., Chakraborty, S., Yu, J., Konukiewitz, B., Steiger, K. & Pfarr, N. & 16 others, Rajput, A., Sailer, D., Keller, G., Schirmacher, P., Röcken, C., Fagerstedt, K. W., Mayerle, J., Schmidt-Supprian, M., Schneider, G., Weichert, W., Calado, D. P., Sommermann, T., Klöppel, G., Rajewsky, K., Saur, D. & Rad, R., 10 Jul 2023, In: Cancer Cell. 41, 7, p. 1327-1344.e10

Research output: Contribution to journal › Article › peer-review

Open Access

12 Scopus citations

AP1/Fra1 confers resistance to MAPK cascade inhibition in pancreatic cancer

Schneeweis, C., Diersch, S., Hassan, Z., Krauß, L., Schneider, C., Lucarelli, D., Falcomatà, C., Steiger, K., Öllinger, R., Krämer, O. H., Arlt, A., Grade, M., Schmidt-Supprian, M., Hessmann, E., Wirth, M., Rad, R., Reichert, M., Saur, D. & Schneider, G., Jan 2023, In: Cellular and Molecular Life Sciences. 80, 1, 12.

Research output: Contribution to journal › Article › peer-review

Open Access

7 Scopus citations

Combined proteomics and CRISPR‒Cas9 screens in PDX identify ADAM10 as essential for leukemia in vivo

Bahrami, E., Schmid, J. P., Jurinovic, V., Becker, M., Wirth, A. K., Ludwig, R., Kreissig, S., Duque Angel, T. V., Amend, D., Hunt, K., Öllinger, R., Rad, R., Frenz, J. M., Solovey, M., Ziemann, F., Mann, M., Vick, B., Wichmann, C., Herold, T. & Jayavelu, A. K. & 1 others, Jeremias, I., Dec 2023, In: Molecular Cancer. 22, 1, 107.

Research output: Contribution to journal › Article › peer-review

Open Access

9 Scopus citations

eIF3 mRNA selectivity profiling reveals eIF3k as a cancer-relevant regulator of ribosome content

Duan, H., Zhang, S., Zarai, Y., Öllinger, R., Wu, Y., Sun, L., Hu, C., He, Y., Tian, G., Rad, R., Kong, X., Cheng, Y., Tuller, T. & Wolf, D. A., 15 Jun 2023, In: EMBO Journal. 42, 12, e112362.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Scopus citations

Germ line variant GFI1-36N affects DNA repair and sensitizes AML cells to DNA damage and repair therapy

Frank, D., Patnana, P. K., Vorwerk, J., Mao, L., Gopal, L. M., Jung, N., Hennig, T., Ruhnke, L., Frenz, J. M., Kuppusamy, M., Autry, R., Wei, L., Sun, K., Mohammed Ahmed, H. M., Künstner, A., Busch, H., Müller, H., Hutter, S., Hoermann, G. & Liu, L. & 39 others, Xie, X., Al-Matary, Y., Nimmagadda, S. C., Cano, F. C., Heuser, M., Thol, F., Göhring, G., Steinemann, D., Thomale, J., Leitner, T., Fischer, A., Rad, R., Röllig, C., Altmann, H., Kunadt, D., Berdel, W. E., Hüve, J., Neumann, F., Klingauf, J., Calderon, V., Opalka, B., Dührsen, U., Rosenbauer, F., Dugas, M., Varghese, J., Reinhardt, H. C., von Bubnoff, N., Möröy, T., Lenz, G., Batcha, A. M. N., Giorgi, M., Selvam, M., Wang, E., McWeeney, S. K., Tyner, J. W., Stölzel, F., Mann, M., Jayavelu, A. K. & Khandanpour, C., 21 Dec 2023, In: Blood. 142, 25, p. 2175-2191 17 p.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

Intestinal B cells license metabolic T-cell activation in NASH microbiota/antigen-independently and contribute to fibrosis by IgA-FcR signalling

Kotsiliti, E., Leone, V., Schuehle, S., Govaere, O., Li, H., Wolf, M. J., Horvatic, H., Bierwirth, S., Hundertmark, J., Inverso, D., Zizmare, L., Sarusi-Portuguez, A., Gupta, R., O'Connor, T., Giannou, A. D., Shiri, A. M., Schlesinger, Y., Beccaria, M. G., Rennert, C. & Pfister, D. & 52 others, Öllinger, R., Gadjalova, I., Ramadori, P., Rahbari, M., Rahbari, N., Healy, M. E., Fernández-Vaquero, M., Yahoo, N., Janzen, J., Singh, I., Fan, C., Liu, X., Rau, M., Feuchtenberger, M., Schwaneck, E., Wallace, S. J., Cockell, S., Wilson-Kanamori, J., Ramachandran, P., Kho, C., Kendall, T. J., Leblond, A. L., Keppler, S. J., Bielecki, P., Steiger, K., Hofmann, M., Rippe, K., Zitzelsberger, H., Weber, A., Malek, N., Luedde, T., Vucur, M., Augustin, H. G., Flavell, R., Parnas, O., Rad, R., Pabst, O., Henderson, N. C., Huber, S., Macpherson, A., Knolle, P., Claassen, M., Geier, A., Trautwein, C., Unger, K., Elinav, E., Waisman, A., Abdullah, Z., Haller, D., Tacke, F., Anstee, Q. M. & Heikenwalder, M., Aug 2023, In: Journal of Hepatology. 79, 2, p. 296-313 18 p.

Research output: Contribution to journal › Article › peer-review

Open Access

44 Scopus citations

In vivo interrogation of regulatory genomes reveals extensive quasi-insufficiency in cancer evolution

Fischer, A., Lersch, R., de Andrade Krätzig, N., Strong, A., Friedrich, M. J., Weber, J., Engleitner, T., Öllinger, R., Yen, H. Y., Kohlhofer, U., Gonzalez-Menendez, I., Sailer, D., Kogan, L., Lahnalampi, M., Laukkanen, S., Kaltenbacher, T., Klement, C., Rezaei, M., Ammon, T. & Montero, J. J. & 16 others, Schneider, G., Mayerle, J., Heikenwälder, M., Schmidt-Supprian, M., Quintanilla-Martinez, L., Steiger, K., Liu, P., Cadiñanos, J., Vassiliou, G. S., Saur, D., Lohi, O., Heinäniemi, M., Conte, N., Bradley, A., Rad, L. & Rad, R., 8 Mar 2023, In: Cell Genomics. 3, 3, 100276.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

mRNA 3’UTR lengthening by alternative polyadenylation attenuates inflammatory responses and correlates with virulence of Influenza A virus

Bergant, V., Schnepf, D., de Andrade Krätzig, N., Hubel, P., Urban, C., Engleitner, T., Dijkman, R., Ryffel, B., Steiger, K., Knolle, P. A., Kochs, G., Rad, R., Staeheli, P. & Pichlmair, A., Dec 2023, In: Nature Communications. 14, 1, 4906.

Research output: Contribution to journal › Article › peer-review

Open Access

7 Scopus citations

N-acetylcysteine overcomes NF1 loss-driven resistance to PI3Kα inhibition in breast cancer

Auf der Maur, P., Trefny, M. P., Baumann, Z., Vulin, M., Correia, A. L., Diepenbruck, M., Kramer, N., Volkmann, K., Preca, B. T., Ramos, P., Leroy, C., Eichlisberger, T., Buczak, K., Zilli, F., Okamoto, R., Rad, R., Jensen, M. R., Fritsch, C., Zippelius, A. & Stadler, M. B. & 1 others, Bentires-Alj, M., 18 Apr 2023, In: Cell Reports Medicine. 4, 4, 101002.

Research output: Contribution to journal › Article › peer-review

Open Access

7 Scopus citations

Negative feedback regulation of MAPK signaling is an important driver of chronic lymphocytic leukemia progression

Ecker, V., Brandmeier, L., Stumpf, M., Giansanti, P., Moreira, A. V., Pfeuffer, L., Fens, M. H. A. M., Lu, J., Kuster, B., Engleitner, T., Heidegger, S., Rad, R., Ringshausen, I., Zenz, T., Wendtner, C. M., Müschen, M., Jellusova, J., Ruland, J. & Buchner, M., 31 Oct 2023, In: Cell Reports. 42, 10, 113017.

Research output: Contribution to journal › Article › peer-review

Open Access

9 Scopus citations

Non-canonical functions of SNAIL drive context-specific cancer progression

Paul, M. C., Schneeweis, C., Falcomatà, C., Shan, C., Rossmeisl, D., Koutsouli, S., Klement, C., Zukowska, M., Widholz, S. A., Jesinghaus, M., Heuermann, K. K., Engleitner, T., Seidler, B., Sleiman, K., Steiger, K., Tschurtschenthaler, M., Walter, B., Weidemann, S. A., Pietsch, R. & Schnieke, A. & 7 others, Schmid, R. M., Robles, M. S., Andrieux, G., Boerries, M., Rad, R., Schneider, G. & Saur, D., Dec 2023, In: Nature Communications. 14, 1, 1201.

Research output: Contribution to journal › Article › peer-review

Open Access

15 Scopus citations

Osteoprogenitor SFRP1 prevents exhaustion of hematopoietic stem cells via PP2A-PR72/130-mediated regulation of p300

Hettler, F., Schreck, C., Marquez, S. R., Engleitner, T., Vilne, B., Landspersky, T., Weidner, H., Hausinger, R., Mishra, R., Oellinger, R., Rauner, M., Naumann, R., Peschel, C., Bassermann, F., Rad, R., Istvanffy, R. & Oostendorp, R. A. J., Feb 2023, In: Haematologica. 108, 2, p. 490-501 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

Ovulation is triggered by a cyclical modulation of gonadotropes into a hyperexcitable state

Götz, V., Qiao, S., Das, D., Wartenberg, P., Wyatt, A., Wahl, V., Gamayun, I., Alasmi, S., Fecher-Trost, C., Meyer, M. R., Rad, R., Kaltenbacher, T., Kattler, K., Lipp, P., Becherer, U., Mollard, P., Candlish, M. & Boehm, U., 27 Jun 2023, In: Cell Reports. 42, 6, 112543.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

PD-1 instructs a tumor-suppressive metabolic program that restricts glycolysis and restrains AP-1 activity in T cell lymphoma

Wartewig, T., Daniels, J., Schulz, M., Hameister, E., Joshi, A., Park, J., Morrish, E., Venkatasubramani, A. V., Cernilogar, F. M., van Heijster, F. H. A., Hundshammer, C., Schneider, H., Konstantinidis, F., Gabler, J. V., Klement, C., Kurniawan, H., Law, C., Lee, Y., Choi, S. & Guitart, J. & 13 others, Forne, I., Giustinani, J., Müschen, M., Jain, S., Weinstock, D. M., Rad, R., Ortonne, N., Schilling, F., Schotta, G., Imhof, A., Brenner, D., Choi, J. & Ruland, J., Oct 2023, In: Nature Cancer. 4, 10, p. 1508-1525 18 p.

Research output: Contribution to journal › Article › peer-review

Open Access

18 Scopus citations

PD-L1 positive astrocytes attenuate inflammatory functions of PD-1 positive microglia in models of autoimmune neuroinflammation

Linnerbauer, M., Beyer, T., Nirschl, L., Farrenkopf, D., Lößlein, L., Vandrey, O., Peter, A., Tsaktanis, T., Kebir, H., Laplaud, D., Oellinger, R., Engleitner, T., Alvarez, J. I., Rad, R., Korn, T., Hemmer, B., Quintana, F. J. & Rothhammer, V., Dec 2023, In: Nature Communications. 14, 1, 5555.

Research output: Contribution to journal › Article › peer-review

Open Access

14 Scopus citations

Phenotype screens of murine pancreatic cancer identify a Tgf-α-Ccl2-paxillin axis driving human-like neural invasion

Wang, X., Istvanffy, R., Ye, L., Teller, S., Laschinger, M., Diakopoulos, K. N., Görgülü, K., Li, Q., Ren, L., Jäger, C., Steiger, K., Muckenhuber, A., Vilne, B., Çifcibaşı, K., Reyes, C. M., Yurteri, Ü., Kießler, M., Gürçınar, I. H., Sugden, M. & Yıldızhan, S. E. & 15 others, Sezerman, O. U., Çilingir, S., Süyen, G., Reichert, M., Schmid, R. M., Bärthel, S., Oellinger, R., Krüger, A., Rad, R., Saur, D., Algül, H., Friess, H., Lesina, M., Ceyhan, G. O. & Demir, I. E., 1 Nov 2023, In: Journal of Clinical Investigation. 133, 21, e166333.

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Open Access

6 Scopus citations

Proteogenomic analysis reveals RNA as a source for tumor-agnostic neoantigen identification

Tretter, C., de Andrade Krätzig, N., Pecoraro, M., Lange, S., Seifert, P., von Frankenberg, C., Untch, J., Zuleger, G., Wilhelm, M., Zolg, D. P., Dreyer, F. S., Bräunlein, E., Engleitner, T., Uhrig, S., Boxberg, M., Steiger, K., Slotta-Huspenina, J., Ochsenreither, S., von Bubnoff, N. & Bauer, S. & 19 others, Boerries, M., Jost, P. J., Schenck, K., Dresing, I., Bassermann, F., Friess, H., Reim, D., Grützmann, K., Pfütze, K., Klink, B., Schröck, E., Haller, B., Kuster, B., Mann, M., Weichert, W., Fröhling, S., Rad, R., Hiltensperger, M. & Krackhardt, A. M., Dec 2023, In: Nature Communications. 14, 1, 4632.

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Open Access

17 Scopus citations

Systematic P2Y receptor survey identifies P2Y11 as modulator of immune responses and virus replication in macrophages

Andersen, L. L., Huang, Y., Urban, C., Oubraham, L., Winheim, E., Stafford, C., Nagl, D., O'Duill, F., Ebert, T., Engleitner, T., Paludan, S. R., Krug, A., Rad, R., Hornung, V. & Pichlmair, A., 1 Dec 2023, In: EMBO Journal. 42, 23, e113279.

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Open Access

2 Scopus citations

Targeting nucleic acid sensors in tumor cells to reprogram biogenesis and RNA cargo of extracellular vesicles for T cell-mediated cancer immunotherapy

Heidegger, S., Stritzke, F., Dahl, S., Daßler-Plenker, J., Joachim, L., Buschmann, D., Fan, K., Sauer, C. M., Ludwig, N., Winter, C., Enssle, S., Li, S., Perl, M., Görgens, A., Haas, T., Orberg, E. T., Göttert, S., Wölfel, C., Engleitner, T. & Cortés-Ciriano, I. & 8 others, Rad, R., Herr, W., Giebel, B., Ruland, J., Bassermann, F., Coch, C., Hartmann, G. & Poeck, H., 19 Sep 2023, In: Cell Reports Medicine. 4, 9, 101171.

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Open Access

8 Scopus citations

Transmicron: Accurate prediction of insertion probabilities improves detection of cancer driver genes from transposon mutagenesis screens

Bredthauer, C., Fischer, A., Ahari, A. J., Cao, X., Weber, J., Rad, L., Rad, R., Wachutka, L. & Gagneur, J., 28 Feb 2023, In: Nucleic Acids Research. 51, 4, p. E21-E21

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Open Access

3 Scopus citations

Trimannose-coupled antimiR-21 for macrophage-targeted inhalation treatment of acute inflammatory lung damage

Beck, C., Ramanujam, D., Vaccarello, P., Widenmeyer, F., Feuerherd, M., Cheng, C. C., Bomhard, A., Abikeeva, T., Schädler, J., Sperhake, J. P., Graw, M., Safi, S., Hoffmann, H., Staab-Weijnitz, C. A., Rad, R., Protzer, U., Frischmuth, T. & Engelhardt, S., Dec 2023, In: Nature Communications. 14, 1, 4564.

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Open Access

12 Scopus citations

Tumor-derived prostaglandin E2 programs cDC1 dysfunction to impair intratumoral orchestration of anti-cancer T cell responses

Bayerl, F., Meiser, P., Donakonda, S., Hirschberger, A., Lacher, S. B., Pedde, A. M., Hermann, C. D., Elewaut, A., Knolle, M., Ramsauer, L., Rudolph, T. J., Grassmann, S., Öllinger, R., Kirchhammer, N., Trefny, M., Anton, M., Wohlleber, D., Höchst, B., Zaremba, A. & Krüger, A. & 7 others, Rad, R., Obenauf, A. C., Schadendorf, D., Zippelius, A., Buchholz, V. R., Schraml, B. U. & Böttcher, J. P., 13 Jun 2023, In: Immunity. 56, 6, p. 1341-1358.e11

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Open Access

74 Scopus citations

2022

A GATA6-centred gene regulatory network involving HNFs and "np63 controls plasticity and immune escape in pancreatic cancer

Kloesch, B., Ionasz, V., Paliwal, S., Hruschka, N., Martinez De Villarreal, J., Öllinger, R., Mueller, S., Dienes, H. P., Schindl, M., Gruber, E. S., Stift, J., Herndler-Brandstetter, D., Lomberk, G. A., Seidler, B., Saur, D., Rad, R., Urrutia, R. A., Real, F. X. & Martinelli, P., 1 Apr 2022, In: Gut. 71, 4, p. 766-777 12 p.

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Open Access

53 Scopus citations

A novel Cereblon E3 ligase modulator with antitumor activity in gastrointestinal cancer

Lier, S., Sellmer, A., Orben, F., Heinzlmeir, S., Krauß, L., Schneeweis, C., Hassan, Z., Schneider, C., Patricia Gloria Schäfer, A., Pongratz, H., Engleitner, T., Öllinger, R., Kuisl, A., Bassermann, F., Schlag, C., Kong, B., Dove, S., Kuster, B., Rad, R. & Reichert, M. & 4 others, Wirth, M., Saur, D., Mahboobi, S. & Schneider, G., Feb 2022, In: Bioorganic Chemistry. 119, 105505.

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Open Access

17 Scopus citations

CCL17 Promotes Colitis-Associated Tumorigenesis Dependent on the Microbiota

Metzger, R., Winter, L., Bouznad, N., Garzetti, D., von Armansperg, B., Rokavec, M., Lutz, K., Schäfer, Y., Krebs, S., Winheim, E., Friedrich, V., Matzek, D., Öllinger, R., Rad, R., Stecher, B., Hermeking, H., Brocker, T. & Krug, A. B., 1 Dec 2022, In: Journal of Immunology. 209, 11, p. 2227-2238 12 p.

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Open Access

2 Scopus citations

Comparative Study of the Role of Interepithelial Mucosal Mast Cells in the Context of Intestinal Adenoma-Carcinoma Progression

Groll, T., Silva, M., Sarker, R. S. J., Tschurtschenthaler, M., Schnalzger, T., Mogler, C., Denk, D., Schölch, S., Schraml, B. U., Ruland, J., Rad, R., Saur, D., Weichert, W., Jesinghaus, M., Matiasek, K. & Steiger, K., 1 May 2022, In: Cancers. 14, 9, 2248.

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Open Access

5 Scopus citations

Disease Modeling on Tumor Organoids Implicates AURKA as a Therapeutic Target in Liver Metastatic Colorectal Cancer

Boos, S. L., Loevenich, L. P., Vosberg, S., Engleitner, T., Öllinger, R., Kumbrink, J., Rokavec, M., Michl, M., Greif, P. A., Jung, A., Hermeking, H., Neumann, J., Kirchner, T., Rad, R. & Jung, P., Jan 2022, In: CMGH. 13, 2, p. 517-540 24 p.

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Open Access

20 Scopus citations

Endothelial Retargeting of AAV9 In Vivo

Bozoglu, T., Lee, S., Ziegler, T., Jurisch, V., Maas, S., Baehr, A., Hinkel, R., Hoenig, A., Hariharan, A., Kim, C. I., Decker, S., Sami, H., Koppara, T., Oellinger, R., Müller, O. J., Frank, D., Megens, R., Nelson, P., Weber, C. & Schnieke, A. & 8 others, Sperandio, M., Santamaria, G., Rad, R., Moretti, A., Laugwitz, K. L., Soehnlein, O., Ogris, M. & Kupatt, C., 4 Mar 2022, In: Advanced Science. 9, 7, 2103867.

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Open Access

24 Scopus citations

Epigenetic drug screening defines a PRMT5 inhibitor-sensitive pancreatic cancer subtype

Orben, F., Lankes, K., Schneeweis, C., Hassan, Z., Jakubowsky, H., Krauß, L., Boniolo, F., Schneider, C., Schäfer, A., Murr, J., Schlag, C., Kong, B., Öllinger, R., Wang, C., Beyer, G., Mahajan, U. M., Xue, Y., Mayerle, J., Schmid, R. M. & Kuster, B. & 6 others, Rad, R., Braun, C. J., Wirth, M., Reichert, M., Saur, D. & Schneider, G., 23 May 2022, In: JCI Insight. 7, 10, e151353.

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Open Access

16 Scopus citations

Institute of Molecular Oncology and Functional Genomics

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