Chair of Silicon Chemistry

2021

Proteolysis of Rab32 by Salmonella GtgE induces an inactive GTPase conformation

Savitskiy, S., Wachtel, R., Pourjafar-Dehkordi, D., Kang, H. S., Trauschke, V., Lamb, D. C., Sattler, M., Zacharias, M. & Itzen, A., 22 Jan 2021, In: iScience. 24, 1, 101940.

Research output: Contribution to journal › Article › peer-review

Open Access

13 Scopus citations

Rab1-AMPylation by Legionella DrrA is allosterically activated by Rab1

Du, J., Wrisberg, M. K. V., Gulen, B., Stahl, M., Pett, C., Hedberg, C., Lang, K., Schneider, S. & Itzen, A., 1 Dec 2021, In: Nature Communications. 12, 1, 460.

Research output: Contribution to journal › Article › peer-review

Open Access

17 Scopus citations

Reversible Activation and Transfer of White Phosphorus by Silyl-Stannylene

Sarkar, D., Weetman, C., Munz, D. & Inoue, S., 15 Feb 2021, In: Angewandte Chemie International Edition in English. 60, 7, p. 3519-3523 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

41 Scopus citations

SopD from Salmonella specifically inactivates Rab8

Savitskiy, S. & Itzen, A., Aug 2021, In: Biochimica et Biophysica Acta - Proteins and Proteomics. 1869, 8, 140661.

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Specificity of AMPylation of the human chaperone BiP is mediated by TPR motifs of FICD

Fauser, J., Gulen, B., Pogenberg, V., Pett, C., Pourjafar-Dehkordi, D., Krisp, C., Höpfner, D., König, G., Schlüter, H., Feige, M. J., Zacharias, M., Hedberg, C. & Itzen, A., 1 Dec 2021, In: Nature Communications. 12, 1, 2426.

Research output: Contribution to journal › Article › peer-review

Open Access

19 Scopus citations

2020

An Air-Stable Heterobimetallic Si₂M₂ Tetrahedral Cluster

Dübek, G., Hanusch, F., Munz, D. & Inoue, S., 27 Mar 2020, In: Angewandte Chemie International Edition in English. 59, 14, p. 5823-5829 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

9 Scopus citations

Application of multifunctional silylenes and siliranes as universal crosslinkers for metal-free curing of silicones

Herz, F. A. D., Nobis, M., Wendel, D., Pahl, P., Altmann, P. J., Tillmann, J., Weidner, R., Inoue, S. & Rieger, B., 21 Jul 2020, In: Green Chemistry. 22, 14, p. 4489-4497 9 p.

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Conformational control of small GTPases by AMPylation

Barthelmes, K., Ramcke, E., Kang, H. S., Sattler, M. & Itzen, A., 17 Mar 2020, In: Proceedings of the National Academy of Sciences of the United States of America. 117, 11, p. 5772-5781 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

13 Scopus citations

Dialumenes-aryl: Vs. silyl stabilisation for small molecule activation and catalysis

Weetman, C., Porzelt, A., Bag, P., Hanusch, F. & Inoue, S., 14 May 2020, In: Chemical Science. 11, 18, p. 4817-4827 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

75 Scopus citations

Divergent evolution of legionella RCC1 repeat effectors defines the range of ran gtpase cycle targets

Swart, A. L., Steiner, B., Gomez-Valero, L., Schütz, S., Hannemann, M., Janning, P., Irminger, M., Rothmeier, E., Buchrieser, C., Itzen, A., Panse, V. G. & Hilbi, H., 1 Mar 2020, In: mBio. 11, 2, e00405-20.

Research output: Contribution to journal › Article › peer-review

Open Access

9 Scopus citations

DMAP-stabilized bis(silyl)silylenes as versatile synthons for organosilicon compounds

Holzner, R., Reiter, D., Frisch, P. & Inoue, S., 2020, In: RSC Advances. 10, 6, p. 3402-3406 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

22 Scopus citations

Facile Access to Dative, Single, and Double Silicon−Metal Bonds Through M−Cl Insertion Reactions of Base-Stabilized Si^II Cations

Frisch, P., Szilvási, T. & Inoue, S., 15 May 2020, In: Chemistry - A European Journal. 26, 28, p. 6271-6278 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

8 Scopus citations

Identification of targets of AMPylating Fic enzymes by co-substrate-mediated covalent capture

Gulen, B., Rosselin, M., Fauser, J., Albers, M. F., Pett, C., Krisp, C., Pogenberg, V., Schlüter, H., Hedberg, C. & Itzen, A., 1 Aug 2020, In: Nature Chemistry. 12, 8, p. 732-739 8 p.

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Isolation and Reactivity of Chlorotetryliumylidenes Using a Bidentate Bis(N-heterocyclic imine) Ligand

Tschernuth, F. S., Hanusch, F., Szilvási, T. & Inoue, S., 14 Dec 2020, In: Organometallics. 39, 23, p. 4265-4272 8 p.

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Legionella effector AnkX displaces the switch II region for Rab1b phosphocholination

Ernst, S., Ecker, F., Kaspers, M. S., Ochtrop, P., Hedberg, C., Groll, M. & Itzen, A., May 2020, In: Science Advances. 6, 20, eaaz8041.

Research output: Contribution to journal › Article › peer-review

Open Access

11 Scopus citations

Lewis base-stabilized silyliumylidene ions in transition metal coordination chemistry

Frisch, P. & Inoue, S., 21 May 2020, In: Dalton Transactions. 49, 19, p. 6176-6182 7 p.

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Monoclonal Anti-AMP Antibodies Are Sensitive and Valuable Tools for Detecting Patterns of AMPylation

Höpfner, D., Fauser, J., Kaspers, M. S., Pett, C., Hedberg, C. & Itzen, A., 18 Dec 2020, In: iScience. 23, 12, 101800.

Research output: Contribution to journal › Article › peer-review

Open Access

17 Scopus citations

N-Heterocyclic Carbene-Stabilized Germa-acylium Ion: Reactivity and Utility in Catalytic CO₂Functionalizations

Sarkar, D., Weetman, C., Dutta, S., Schubert, E., Jandl, C., Koley, D. & Inoue, S., 9 Sep 2020, In: Journal of the American Chemical Society. 142, 36, p. 15403-15411 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

52 Scopus citations

Oxidation reactions of a versatile, two-coordinate, acyclic iminosiloxysilylene

Reiter, D., Frisch, P., Wendel, D., Hörmann, F. M. & Inoue, S., 7 Jun 2020, In: Dalton Transactions. 49, 21, p. 7060-7068 9 p.

Research output: Contribution to journal › Article › peer-review

50 Scopus citations

PINK1-dependent phosphorylation of serine111 within the SF3 motif of rab GTPases impairs effector interactions and LRRK2-mediated phosphorylation at Threonine72

Vieweg, S., Mulholland, K., Bräuning, B., Kachariya, N., Lai, Y. C., Toth, R., Singh, P. K., Volpi, I., Sattler, M., Groll, M., Itzen, A. & Muqit, M. M. K., May 2020, In: Biochemical Journal. 477, 9, p. 1651-1668 18 p.

Research output: Contribution to journal › Article › peer-review

Open Access

24 Scopus citations

Silylated silicon–carbonyl complexes as mimics of ubiquitous transition-metal carbonyls

Reiter, D., Holzner, R., Porzelt, A., Frisch, P. & Inoue, S., Dec 2020, In: Nature Chemistry. 12, 12, p. 1131-1135 5 p.

Research output: Contribution to journal › Article › peer-review

62 Scopus citations

The trimer to monomer transition of Tumor Necrosis Factor-Alpha is a dynamic process that is significantly altered by therapeutic antibodies

Daub, H., Traxler, L., Ismajli, F., Groitl, B., Itzen, A. & Rant, U., 1 Dec 2020, In: Scientific Reports. 10, 1, 9265.

Research output: Contribution to journal › Article › peer-review

Open Access

32 Scopus citations

Validation of the Slow Off-Kinetics of Sirtuin-Rearranging Ligands (SirReals) by Means of Label-Free Electrically Switchable Nanolever Technology

Schiedel, M., Daub, H., Itzen, A. & Jung, M., 17 Apr 2020, In: ChemBioChem. 21, 8, p. 1161-1166 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

7 Scopus citations

2019

Catalytic CO₂ Reduction with Boron- and Aluminum Hydrides

Franz, D., Jandl, C., Stark, C. & Inoue, S., 7 Nov 2019, In: ChemCatChem. 11, 21, p. 5275-5281 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

52 Scopus citations

CO₂ Fixation and Catalytic Reduction by a Neutral Aluminum Double Bond

Weetman, C., Bag, P., Szilvási, T., Jandl, C. & Inoue, S., 5 Aug 2019, In: Angewandte Chemie International Edition in English. 58, 32, p. 10961-10965 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

80 Scopus citations

Disilene-Silylene Interconversion: A Synthetically Accessible Acyclic Bis(silyl)silylene

Reiter, D., Holzner, R., Porzelt, A., Altmann, P. J., Frisch, P. & Inoue, S., 28 Aug 2019, In: Journal of the American Chemical Society. 141, 34, p. 13536-13546 11 p.

Research output: Contribution to journal › Article › peer-review

71 Scopus citations

Heavier Carbonyl Olefination: The Sila-Wittig Reaction

Reiter, D., Frisch, P., Szilvási, T. & Inoue, S., 23 Oct 2019, In: Journal of the American Chemical Society. 141, 42, p. 16991-16996 6 p.

Research output: Contribution to journal › Article › peer-review

41 Scopus citations

Isolation of an N-Heterocyclic Carbene Complex of a Borasilene

Franz, D., Szilvási, T., Pöthig, A. & Inoue, S., 22 Aug 2019, In: Chemistry - A European Journal. 25, 47, p. 11036-11041 6 p.

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Isolation of a Relatively Air-Stable, Bulky Silyl-Substituted, Neutral Silicon-Centered Radical

Holzner, R., Kaushansky, A., Tumanskii, B., Frisch, P., Linsenmann, F. & Inoue, S., 7 Jul 2019, In: European Journal of Inorganic Chemistry. 2019, 25, p. 2977-2981 5 p.

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

NHC-Stabilized Silyl-Substituted Chlorosilylene

Dübek, G., Hanusch, F. & Inoue, S., 2 Dec 2019, In: Inorganic Chemistry. 58, 23, p. 15700-15704 5 p.

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

NHC-stabilized silyl-substituted silyliumylidene ions

Frisch, P. & Inoue, S., 2019, In: Dalton Transactions. 48, 28, p. 10403-10406 4 p.

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

N-Heterocyclic Carbene-Stabilized Germanium and Tin Analogues of Heavier Nitriles: Synthesis, Reactivity, and Catalytic Application

Nesterov, V., Baierl, R., Hanusch, F., Ferao, A. E. & Inoue, S., 18 Sep 2019, In: Journal of the American Chemical Society. 141, 37, p. 14576-14580 5 p.

Research output: Contribution to journal › Article › peer-review

73 Scopus citations

NHI-and NHC-supported Al(III) hydrides for amine-borane dehydrocoupling catalysis

Weetman, C., Ito, N., Unno, M., Hanusch, F. & Inoue, S., 2019, In: Inorganics. 7, 8, 92.

Research output: Contribution to journal › Article › peer-review

Open Access

11 Scopus citations

Nucleotide exchange factor Rab3GEP requires DENN and non-DENN elements for activation and targeting of rab27a

Sanza, P., Evans, R. D., Briggs, D. A., Cantero, M., Montoliu, L., Patel, S., Sviderskaya, E. V., Itzen, A., Figueiredo, A. C., Seabra, M. C. & Hume, A. N., 1 May 2019, In: Journal of Cell Science. 132, 9, jcs212035.

Research output: Contribution to journal › Article › peer-review

Open Access

9 Scopus citations

Reactivity of an NHC-stabilized pyramidal hydrosilylene with electrophilic boron sources

Dübek, G., Franz, D., Eisenhut, C., Altmann, P. J. & Inoue, S., 2019, In: Dalton Transactions. 48, 17, p. 5756-5765 10 p.

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

The Quest for Stable Silaaldehydes: Synthesis and Reactivity of a Masked Silacarbonyl

Sarkar, D., Nesterov, V., Szilvási, T., Altmann, P. J. & Inoue, S., 24 Jan 2019, In: Chemistry - A European Journal. 25, 5, p. 1198-1202 5 p.

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Transition Metal Carbonyl Complexes of an N-Heterocyclic Carbene Stabilized Silyliumylidene Ion

Frisch, P., Szilvási, T., Porzelt, A. & Inoue, S., 4 Nov 2019, In: Inorganic Chemistry. 58, 21, p. 14931-14937 7 p.

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

2018

Coinage metal complexes of NHC-stabilized silyliumylidene ions

Frisch, P. & Inoue, S., 2018, In: Chemical Communications. 54, 97, p. 13658-13661 4 p.

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Precise Activation of Ammonia and Carbon Dioxide by an Iminodisilene

Wendel, D., Szilvási, T., Henschel, D., Altmann, P. J., Jandl, C., Inoue, S. & Rieger, B., 26 Oct 2018, In: Angewandte Chemie International Edition in English. 57, 44, p. 14575-14579 5 p.

Research output: Contribution to journal › Article › peer-review

59 Scopus citations

S-H bond activation in hydrogen sulfide by NHC-stabilized silyliumylidene ions

Porzelt, A., Schweizer, J. I., Baierl, R., Altmann, P. J., Holthausen, M. C. & Inoue, S., Jun 2018, In: Inorganics. 6, 2, 54.

Research output: Contribution to journal › Article › peer-review

Open Access

16 Scopus citations

The protease GtgE from Salmonella exclusively targets inactive Rab GTPases

Wachtel, R., Bräuning, B., Mader, S. L., Ecker, F., Kaila, V. R. I., Groll, M. & Itzen, A., 1 Dec 2018, In: Nature Communications. 9, 1, 44.

Research output: Contribution to journal › Article › peer-review

Open Access

27 Scopus citations

The Road Travelled: After Main-Group Elements as Transition Metals

Weetman, C. & Inoue, S., 9 Oct 2018, In: ChemCatChem. 10, 19, p. 4213-4228 16 p.

Research output: Contribution to journal › Article › peer-review

Open Access

399 Scopus citations

Three-Coordinate Boron(III) and Diboron(II) Dications

Franz, D., Szilvási, T., Pöthig, A., Deiser, F. & Inoue, S., 20 Mar 2018, In: Chemistry - A European Journal. 24, 17, p. 4283-4288 6 p.

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

2017

A Stable Neutral Compound with an Aluminum-Aluminum Double Bond

Bag, P., Porzelt, A., Altmann, P. J. & Inoue, S., 18 Oct 2017, In: Journal of the American Chemical Society. 139, 41, p. 14384-14387 4 p.

Research output: Contribution to journal › Article › peer-review

134 Scopus citations

Chalcogen-atom transfer and exchange reactions of NHC-stabilized heavier silaacylium ions

Sarkar, D., Wendel, D., Ahmad, S. U., Szilvási, T., Pöthig, A. & Inoue, S., 2017, In: Dalton Transactions. 46, 46, p. 16014-16018 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

21 Scopus citations

From Si(II) to Si(IV) and Back: Reversible Intramolecular Carbon-Carbon Bond Activation by an Acyclic Iminosilylene

Wendel, D., Porzelt, A., Herz, F. A. D., Sarkar, D., Jandl, C., Inoue, S. & Rieger, B., 21 Jun 2017, In: Journal of the American Chemical Society. 139, 24, p. 8134-8137 4 p.

Research output: Contribution to journal › Article › peer-review

144 Scopus citations

Proximity-Triggered Covalent Stabilization of Low-Affinity Protein Complexes In Vitro and In Vivo

Cigler, M., Müller, T. G., Horn-Ghetko, D., von Wrisberg, M. K., Fottner, M., Goody, R. S., Itzen, A., Müller, M. P. & Lang, K., 4 Dec 2017, In: Angewandte Chemie International Edition in English. 56, 49, p. 15737-15741 5 p.

Research output: Contribution to journal › Article › peer-review

63 Scopus citations

Silicon and Oxygen's Bond of Affection: An Acyclic Three-Coordinate Silanone and Its Transformation to an Iminosiloxysilylene

Wendel, D., Reiter, D., Porzelt, A., Altmann, P. J., Inoue, S. & Rieger, B., 29 Nov 2017, In: Journal of the American Chemical Society. 139, 47, p. 17193-17198 6 p.

Research output: Contribution to journal › Article › peer-review

120 Scopus citations

Synthesis and reactivity of functionalized silicon(II) compounds: Iminosilylene, phosphinosilylene, hydrosilylene, and related compounds

Bag, P., Ahmad, S. U. & Inoue, S., 2017, In: Bulletin of the Chemical Society of Japan. 90, 3, p. 255-271 17 p.

Research output: Contribution to journal › Article › peer-review

Open Access

25 Scopus citations

Synthesis of a cyclopentadienyl(imino)stannylene and its direct conversion into halo(imino)stannylenes

Ochiai, T. & Inoue, S., 2017, In: RSC Advances. 7, 2, p. 801-804 4 p.

Research output: Contribution to journal › Article › peer-review

Open Access

16 Scopus citations

Chair of Silicon Chemistry

Research output

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