Associate Professorship of Translationale Pankreaskrebsforschung

2025

A decision point between transdifferentiation and programmed cell death priming controls KRAS-dependent pancreatic cancer development

Schneider, A. T., Koppe, C., Crouchet, E., Papargyriou, A., Singer, M. T., Büttner, V., Keysberg, L., Szydlowska, M., Jühling, F., Moehlin, J., Chen, M. C., Leone, V., Mueller, S., Neuß, T., Castoldi, M., Lesina, M., Bergmann, F., Hackert, T., Steiger, K. & Knoefel, W. T. & 18 others, Zaufel, A., Kather, J. N., Esposito, I., Gaida, M. M., Ghallab, A., Hengstler, J. G., Einwächter, H., Unger, K., Algül, H., Gassler, N., Schmid, R. M., Rad, R., Baumert, T. F., Reichert, M., Heikenwalder, M., Kondylis, V., Vucur, M. & Luedde, T., Dec 2025, In: Nature Communications. 16, 1, 1765.

Research output: Contribution to journal › Article › peer-review

Open Access

Disrupting AGR2/IGF1 paracrine and reciprocal signaling for pancreatic cancer therapy

Li, H., Zhang, Z., Shi, Z., Zhou, S., Nie, S., Yu, Y., Zhang, L., Sun, Y., Fang, C., Hu, J., Niu, Y., Schuck, K., Wang, L., Jiang, K., Lu, Z., Kahlert, C., Roth, S., Loos, M., Herr, I. & Sunami, Y. & 8 others, Kleeff, J., Friess, H., Reichert, M., Dantes, Z., Zou, X., Michalski, C. W., Shen, S. & Kong, B., 2025, (Accepted/In press) In: Cell Reports Medicine. 101927.

Research output: Contribution to journal › Article › peer-review

Open Access

Gemcitabine and ATR inhibitors synergize to kill PDAC cells by blocking DNA damage response

Höfer, S., Frasch, L., Brajkovic, S., Putzker, K., Lewis, J., Schürmann, H., Leone, V., Sakhteman, A., The, M., Bayer, F. P., Müller, J., Hamood, F., Siveke, J. T., Reichert, M. & Kuster, B., 2025, (Accepted/In press) In: Molecular Systems Biology. 7902.

Research output: Contribution to journal › Article › peer-review

Open Access

2024

An NFATc1/SMAD3/cJUN Complex Restricted to SMAD4-Deficient Pancreatic Cancer Guides Rational Therapies

Hasselluhn, M. C., Schlösser, D., Versemann, L., Schmidt, G. E., Ulisse, M., Oschwald, J., Zhang, Z., Hamdan, F., Xiao, H., Kopp, W., Spitalieri, J., Kellner, C., Schneider, C., Reutlinger, K., Nagarajan, S., Steuber, B., Sastra, S. A., Palermo, C. F., Appelhans, J. & Bohnenberger, H. & 20 others, Todorovic, J., Kostyuchek, I., Ströbel, P., Bockelmann, A., König, A., Ammer-Herrmenau, C., Schmidleitner, L., Kaulfuß, S., Wollnik, B., Hahn, S. A., Neesse, A., Singh, S. K., Bastians, H., Reichert, M., Sax, U., Olive, K. P., Johnsen, S. A., Schneider, G., Ellenrieder, V. & Hessmann, E., Feb 2024, In: Gastroenterology. 166, 2, p. 298-312.e14

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

A Novel AMPK Inhibitor Sensitizes Pancreatic Cancer Cells to Ferroptosis Induction

Schneider, C., Hilbert, J., Genevaux, F., Höfer, S., Krauß, L., Schicktanz, F., Contreras, C. T., Jansari, S., Papargyriou, A., Richter, T., Alfayomy, A. M., Falcomatà, C., Schneeweis, C., Orben, F., Öllinger, R., Wegwitz, F., Boshnakovska, A., Rehling, P., Müller, D. & Ströbel, P. & 13 others, Ellenrieder, V., Conradi, L., Hessmann, E., Ghadimi, M., Grade, M., Wirth, M., Steiger, K., Rad, R., Kuster, B., Sippl, W., Reichert, M., Saur, D. & Schneider, G., 2024, (Accepted/In press) In: Advanced Science.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Scopus citations

Coexisting mechanisms of luminogenesis in pancreatic cancer-derived organoids

Randriamanantsoa, S. J., Raich, M. K., Saur, D., Reichert, M. & Bausch, A. R., 19 Jul 2024, In: iScience. 27, 7, 110299.

Research output: Contribution to journal › Article › peer-review

Open Access

Heterogeneity-driven phenotypic plasticity and treatment response in branched-organoid models of pancreatic ductal adenocarcinoma

Papargyriou, A., Najajreh, M., Cook, D. P., Maurer, C. H., Bärthel, S., Messal, H. A., Ravichandran, S. K., Richter, T., Knolle, M., Metzler, T., Shastri, A. R., Öllinger, R., Jasper, J., Schmidleitner, L., Wang, S., Schneeweis, C., Ishikawa-Ankerhold, H., Engleitner, T., Mataite, L. & Semina, M. & 24 others, Trabulssi, H., Lange, S., Ravichandra, A., Schuster, M., Mueller, S., Peschke, K., Schäfer, A., Dobiasch, S., Combs, S. E., Schmid, R. M., Bausch, A. R., Braren, R., Heid, I., Scheel, C. H., Schneider, G., Zeigerer, A., Luecken, M. D., Steiger, K., Kaissis, G., van Rheenen, J., Theis, F. J., Saur, D., Rad, R. & Reichert, M., 2024, (Accepted/In press) In: Nature Biomedical Engineering. 102858.

Research output: Contribution to journal › Article › peer-review

Open Access

KRAS^G^12C-inhibitor-based combination therapies for pancreatic cancer: insights from drug screening

Tapia Contreras, C., Falke, J. D., Seifert, D. M., Schneider, C., Krauß, L., Fang, X., Müller, D., Demirdizen, E., Spitzner, M., De Oliveira, T., Schneeweis, C., Gaedcke, J., Kaulfuß, S., Mirzakhani, K., Wollnik, B., Conrads, K., Beißbarth, T., Salinas, G., Hügel, J. & Beyer, N. & 12 others, Rheinländer, S., Sax, U., Wirth, M., Conradi, L. C., Reichert, M., Ellenrieder, V., Ströbel, P., Ghadimi, M., Grade, M., Saur, D., Hessmann, E. & Schneider, G., 2024, (Accepted/In press) In: Molecular Oncology.

Research output: Contribution to journal › Article › peer-review

Open Access

2023

In-vitro model to mimic T cell subset change in human PDAC organoid co-culture

Knoblauch, M., Ma, T., Beirith, I., Koch, D., Hofmann, F., Heinrich, K., Aghamaliev, U., Sirtl, S., Westphalen, C. B., Nieß, H., Reichert, M., Angele, M. K., Regel, I., Bazhin, A. V., Werner, J., Ilmer, M. & Renz, B. W., Nov 2023, In: Journal of Cancer Research and Clinical Oncology. 149, 14, p. 13051-13064 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

7 Scopus citations

Phenotype screens of murine pancreatic cancer identify a Tgf-α-Ccl2-paxillin axis driving human-like neural invasion

Wang, X., Istvanffy, R., Ye, L., Teller, S., Laschinger, M., Diakopoulos, K. N., Görgülü, K., Li, Q., Ren, L., Jäger, C., Steiger, K., Muckenhuber, A., Vilne, B., Çifcibaşı, K., Reyes, C. M., Yurteri, Ü., Kießler, M., Gürçınar, I. H., Sugden, M. & Yıldızhan, S. E. & 15 others, Sezerman, O. U., Çilingir, S., Süyen, G., Reichert, M., Schmid, R. M., Bärthel, S., Oellinger, R., Krüger, A., Rad, R., Saur, D., Algül, H., Friess, H., Lesina, M., Ceyhan, G. O. & Demir, I. E., 1 Nov 2023, In: Journal of Clinical Investigation. 133, 21, e166333.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Scopus citations

Resistance to mesenchymal reprogramming sustains clonal propagation in metastatic breast cancer

Saini, M., Schmidleitner, L., Moreno, H. D., Donato, E., Falcone, M., Bartsch, J. M., Klein, C., Vogel, V., Würth, R., Pfarr, N., Espinet, E., Lehmann, M., Königshoff, M., Reitberger, M., Haas, S., Graf, E., Schwarzmayr, T., Strom, T. M., Spaich, S. & Sütterlin, M. & 8 others, Schneeweiss, A., Weichert, W., Schotta, G., Reichert, M., Aceto, N., Sprick, M. R., Trumpp, A. & Scheel, C. H., 27 Jun 2023, In: Cell Reports. 42, 6, 112533.

Research output: Contribution to journal › Article › peer-review

Open Access

12 Scopus citations

2022

A novel Cereblon E3 ligase modulator with antitumor activity in gastrointestinal cancer

Lier, S., Sellmer, A., Orben, F., Heinzlmeir, S., Krauß, L., Schneeweis, C., Hassan, Z., Schneider, C., Patricia Gloria Schäfer, A., Pongratz, H., Engleitner, T., Öllinger, R., Kuisl, A., Bassermann, F., Schlag, C., Kong, B., Dove, S., Kuster, B., Rad, R. & Reichert, M. & 4 others, Wirth, M., Saur, D., Mahboobi, S. & Schneider, G., Feb 2022, In: Bioorganic Chemistry. 119, 105505.

Research output: Contribution to journal › Article › peer-review

Open Access

17 Scopus citations

Detecting drug resistance in pancreatic cancer organoids guides optimized chemotherapy treatment

Hennig, A., Baenke, F., Klimova, A., Drukewitz, S., Jahnke, B., Brückmann, S., Secci, R., Winter, C., Schmäche, T., Seidlitz, T., Bereuter, J. P., Polster, H., Eckhardt, L., Schneider, S. A., Brückner, S., Schmelz, R., Babatz, J., Kahlert, C., Distler, M. & Hampe, J. & 7 others, Reichert, M., Zeißig, S., Folprecht, G., Weitz, J., Aust, D., Welsch, T. & Stange, D. E., Aug 2022, In: Journal of Pathology. 257, 5, p. 607-619 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

23 Scopus citations

Epigenetic drug screening defines a PRMT5 inhibitor-sensitive pancreatic cancer subtype

Orben, F., Lankes, K., Schneeweis, C., Hassan, Z., Jakubowsky, H., Krauß, L., Boniolo, F., Schneider, C., Schäfer, A., Murr, J., Schlag, C., Kong, B., Öllinger, R., Wang, C., Beyer, G., Mahajan, U. M., Xue, Y., Mayerle, J., Schmid, R. M. & Kuster, B. & 6 others, Rad, R., Braun, C. J., Wirth, M., Reichert, M., Saur, D. & Schneider, G., 23 May 2022, In: JCI Insight. 7, 10, e151353.

Research output: Contribution to journal › Article › peer-review

Open Access

16 Scopus citations

Identification of treatment-induced vulnerabilities in pancreatic cancer patients using functional model systems

Peschke, K., Jakubowsky, H., Schäfer, A., Maurer, C., Lange, S., Orben, F., Bernad, R., Harder, F. N., Eiber, M., Öllinger, R., Steiger, K., Schlitter, M., Weichert, W., Mayr, U., Phillip, V., Schlag, C., Schmid, R. M., Braren, R. F., Kong, B. & Demir, I. E. & 5 others, Friess, H., Rad, R., Saur, D., Schneider, G. & Reichert, M., 7 Apr 2022, In: EMBO Molecular Medicine. 14, 4, e14876.

Research output: Contribution to journal › Article › peer-review

Open Access

19 Scopus citations

NOXA expression drives synthetic lethality to RUNX1 inhibition in pancreatic cancer

Doffo, J., Bamopoulos, S. A., Köse, H., Orben, F., Zang, C., Pons, M., den Dekker, A. T., Brouwer, R. W. W., Baluapuri, A., Habringer, S., Reichert, M., Illendula, A., Krämer, O. H., Schick, M., Wolf, E., van IJcken, W. F. J., Esposito, I., Keller, U., Schneider, G. & Wirth, M., 1 Mar 2022, In: Proceedings of the National Academy of Sciences of the United States of America. 119, 9, e2105691119.

Research output: Contribution to journal › Article › peer-review

Open Access

19 Scopus citations

Selective multi-kinase inhibition sensitizes mesenchymal pancreatic cancer to immune checkpoint blockade by remodeling the tumor microenvironment

Falcomatà, C., Bärthel, S., Widholz, S. A., Schneeweis, C., Montero, J. J., Toska, A., Mir, J., Kaltenbacher, T., Heetmeyer, J., Swietlik, J. J., Cheng, J. Y., Teodorescu, B., Reichert, O., Schmitt, C., Grabichler, K., Coluccio, A., Boniolo, F., Veltkamp, C., Zukowska, M. & Vargas, A. A. & 17 others, Paik, W. H., Jesinghaus, M., Steiger, K., Maresch, R., Öllinger, R., Ammon, T., Baranov, O., Robles, M. S., Rechenberger, J., Kuster, B., Meissner, F., Reichert, M., Flossdorf, M., Rad, R., Schmidt-Supprian, M., Schneider, G. & Saur, D., Mar 2022, In: Nature Cancer. 3, 3, p. 318-336 19 p.

Research output: Contribution to journal › Article › peer-review

Open Access

61 Scopus citations

Spatiotemporal dynamics of self-organized branching in pancreas-derived organoids

Randriamanantsoa, S., Papargyriou, A., Maurer, H. C., Peschke, K., Schuster, M., Zecchin, G., Steiger, K., Öllinger, R., Saur, D., Scheel, C., Rad, R., Hannezo, E., Reichert, M. & Bausch, A. R., Dec 2022, In: Nature Communications. 13, 1, 5219.

Research output: Contribution to journal › Article › peer-review

Open Access

24 Scopus citations

2021

AGR2-Dependent Nuclear Import of RNA Polymerase II Constitutes a Specific Target of Pancreatic Ductal Adenocarcinoma in the Context of Wild-Type p53

Zhang, Z., Li, H., Deng, Y., Schuck, K., Raulefs, S., Maeritz, N., Yu, Y., Hechler, T., Pahl, A., Fernández-Sáiz, V., Wan, Y., Wang, G., Engleitner, T., Öllinger, R., Rad, R., Reichert, M., Diakopoulos, K. N., Weber, V., Li, J. & Shen, S. & 7 others, Zou, X., Kleeff, J., Mihaljevic, A., Michalski, C. W., Algül, H., Friess, H. & Kong, B., Nov 2021, In: Gastroenterology. 161, 5, p. 1601-1614.e23

Research output: Contribution to journal › Article › peer-review

Open Access

15 Scopus citations

Combination therapies induce cancer cell death through the integrated stress response and disturbed pyrimidine metabolism

Hartleben, G., Schorpp, K., Kwon, Y., Betz, B., Tsokanos, F. F., Dantes, Z., Schäfer, A., Rothenaigner, I., Monroy Kuhn, J. M., Morigny, P., Mehr, L., Lin, S., Seitz, S., Tokarz, J., Artati, A., Adamsky, J., Plettenburg, O., Lutter, D., Irmler, M. & Beckers, J. & 5 others, Reichert, M., Hadian, K., Zeigerer, A., Herzig, S. & Berriel Diaz, M., 9 Apr 2021, In: EMBO Molecular Medicine. 13, 4, e12461.

Research output: Contribution to journal › Article › peer-review

Open Access

12 Scopus citations

Genetic screens identify a context-specific pi3k/p27^kip1 node driving extrahepatic biliary cancer

Falcomatà, C., Bärthel, S., Ulrich, A., Diersch, S., Veltkamp, C., Rad, L., Boniolo, F., Solar, M., Steiger, K., Seidler, B., Zukowska, M., Madej, J., Wang, M., Öllinger, R., Maresch, R., Barenboim, M., Eser, S., Tschurtschenthaler, M., Mehrabi, A. & Roessler, S. & 14 others, Goeppert, B., Kind, A., Schnieke, A., Robles, M. S., Bradley, A., Schmid, R. M., Schmidt-Supprian, M., Reichert, M., Weichert, W., Sansom, O. J., Morton, J. P., Rad, R., Schneider, G. & Saur, D., Dec 2021, In: Cancer Discovery. 11, 12, p. 3158-3177 20 p.

Research output: Contribution to journal › Article › peer-review

Open Access

13 Scopus citations

Important role of Nfkb2 in the Kras^G12D-driven carcinogenesis in the pancreas

Hassan, Z., Schneeweis, C., Wirth, M., Müller, S., Geismann, C., Neuß, T., Steiger, K., Krämer, O. H., Schmid, R. M., Rad, R., Arlt, A., Reichert, M., Saur, D. & Schneider, G., Aug 2021, In: Pancreatology. 21, 5, p. 912-919 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

Modeling plasticity and dysplasia of pancreatic ductal organoids derived from human pluripotent stem cells

Breunig, M., Merkle, J., Wagner, M., Melzer, M. K., Barth, T. F. E., Engleitner, T., Krumm, J., Wiedenmann, S., Cohrs, C. M., Perkhofer, L., Jain, G., Krüger, J., Hermann, P. C., Schmid, M., Madácsy, T., Varga, Á., Griger, J., Azoitei, N., Müller, M. & Wessely, O. & 17 others, Robey, P. G., Heller, S., Dantes, Z., Reichert, M., Günes, C., Bolenz, C., Kuhn, F., Maléth, J., Speier, S., Liebau, S., Sipos, B., Kuster, B., Seufferlein, T., Rad, R., Meier, M., Hohwieler, M. & Kleger, A., 3 Jun 2021, In: Cell Stem Cell. 28, 6, p. 1105-1124.e19

Research output: Contribution to journal › Article › peer-review

Open Access

71 Scopus citations

New Insights Into Pancreatic Cancer: Notes from a Virtual Meeting

1 Virtual Göttingen-Munich-Marburg Pancreatic Cancer Meeting, Sep 2021, In: Gastroenterology. 161, 3, p. 785-791 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Scopus citations

PALLD mutation in a European family conveys a stromal predisposition for familial pancreatic cancer

Liotta, L., Lange, S., Maurer, H. C., Olive, K. P., Braren, R., Pfarr, N., Burger, S., Muckenhuber, A., Jesinghaus, M., Steiger, K., Weichert, W., Friess, H., Schmid, R., Algül, H., Jost, P. J., Ramser, J., Fischer, C., Quante, A. S., Reichert, M. & Quante, M., 1 Apr 2021, In: JCI Insight. 6, 8, e141532.

Research output: Contribution to journal › Article › peer-review

Open Access

7 Scopus citations

Penetration of isavuconazole in ascites fluid of critically ill patients

Lahmer, T., Batres Baires, G., Schmid, R. M., Wiessner, J. R., Ulrich, J., Reichert, M., Huber, W., Sörgel, F., Kinzig, M., Rasch, S. & Mayr, U., 2021, In: Journal of Fungi. 7, 5, 376.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Scopus citations

Phosphoproteomics identifies PI3K inhibitor-selective adaptive responses in pancreatic cancer cell therapy and resistance

Cintas, C., Douche, T., Dantes, Z., Mouton-Barbosa, E., Bousquet, M. P., Cayron, C., Therville, N., Pont, F., Ramos-Delgado, F., Guyon, C., Garmy-Susini, B., Cappello, P., Burlet-Schiltz, O., Hirsch, E., Gomez-Brouchet, A., Thibault, B., Reichert, M. & Guillermet-Guibert, J., Dec 2021, In: Molecular Cancer Therapeutics. 20, 12, p. 2433-2445 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Scopus citations

T cells armed with C-X-C chemokine receptor type 6 enhance adoptive cell therapy for pancreatic tumours

Lesch, S., Blumenberg, V., Stoiber, S., Gottschlich, A., Ogonek, J., Cadilha, B. L., Dantes, Z., Rataj, F., Dorman, K., Lutz, J., Karches, C. H., Heise, C., Kurzay, M., Larimer, B. M., Grassmann, S., Rapp, M., Nottebrock, A., Kruger, S., Tokarew, N. & Metzger, P. & 38 others, Hoerth, C., Benmebarek, M. R., Dhoqina, D., Grünmeier, R., Seifert, M., Oener, A., Umut, Ö., Joaquina, S., Vimeux, L., Tran, T., Hank, T., Baba, T., Huynh, D., Megens, R. T. A., Janssen, K. P., Jastroch, M., Lamp, D., Ruehland, S., Di Pilato, M., Pruessmann, J. N., Thomas, M., Marr, C., Ormanns, S., Reischer, A., Hristov, M., Tartour, E., Donnadieu, E., Rothenfusser, S., Duewell, P., König, L. M., Schnurr, M., Subklewe, M., Liss, A. S., Halama, N., Reichert, M., Mempel, T. R., Endres, S. & Kobold, S., Nov 2021, In: Nature Biomedical Engineering. 5, 11, p. 1246-1260 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

115 Scopus citations

2020

SUMO pathway inhibition targets an aggressive pancreatic cancer subtype

Biederstädt, A., Hassan, Z., Schneeweis, C., Schick, M., Schneider, L., Muckenhuber, A., Hong, Y., Siegers, G., Nilsson, L., Wirth, M., Dantes, Z., Steiger, K., Schunck, K., Langston, S., Lenhof, H. P., Coluccio, A., Orben, F., Slawska, J., Scherger, A. & Saur, D. & 7 others, Müller, S., Rad, R., Weichert, W., Nilsson, J., Reichert, M., Schneider, G. & Keller, U., 1 Aug 2020, In: Gut. 69, 8, p. 1472-1482 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

70 Scopus citations

2019

PRRX1 isoforms cooperate with FOXM1 to regulate the DNA damage response in pancreatic cancer cells

Marchand, B., Pitarresi, J. R., Reichert, M., Suzuki, K., Laczkó, D. & Rustgi, A. K., 30 May 2019, In: Oncogene. 38, 22, p. 4325-4339 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

29 Scopus citations

2018

Cholinergic signaling via muscarinic receptors directly and indirectly suppresses pancreatic tumorigenesis and cancer stemness

Renz, B. W., Tanaka, T., Sunagawa, M., Takahashi, R., Jiang, Z., Macchini, M., Dantes, Z., Valenti, G., White, R. A., Middelhoff, M. A., Ilmer, M., Oberstein, P. E., Angele, M. K., Deng, H., Hayakawa, Y., Westphalen, C. B., Werner, J., Remotti, H., Reichert, M. & Tailor, Y. H. & 5 others, Nagar, K., Friedman, R. A., Iuga, A. C., Olive, K. P. & Wang, T. C., Nov 2018, In: Cancer Discovery. 8, 11, p. 1458-1473 16 p.

Research output: Contribution to journal › Article › peer-review

Open Access

195 Scopus citations

ETV5 regulates ductal morphogenesis with Sox9 and is critical for regeneration from pancreatitis

Das, K. K., Heeg, S., Pitarresi, J. R., Reichert, M., Bakir, B., Takano, S., Kopp, J. L., Wahl-Feuerstein, A., Hicks, P., Sander, M. & Rustgi, A. K., Jun 2018, In: Developmental Dynamics. 247, 6, p. 854-866 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Scopus citations

2017

HDAC1 and HDAC2 integrate the expression of p53 mutants in pancreatic cancer

Stojanovic, N., Hassan, Z., Wirth, M., Wenzel, P., Beyer, M., Schäfer, C., Brand, P., Kroemer, A., Stauber, R. H., Schmid, R. M., Arlt, A., Sellmer, A., Mahboobi, S., Rad, R., Reichert, M., Saur, D., Krämer, O. H. & Schneider, G., 30 Mar 2017, In: Oncogene. 36, 13, p. 1804-1815 12 p.

Research output: Contribution to journal › Article › peer-review

87 Scopus citations

2016

Dclk1 Defines Quiescent Pancreatic Progenitors that Promote Injury-Induced Regeneration and Tumorigenesis

Westphalen, C. B., Takemoto, Y., Tanaka, T., Macchini, M., Jiang, Z., Renz, B. W., Chen, X., Ormanns, S., Nagar, K., Tailor, Y., May, R., Cho, Y., Asfaha, S., Worthley, D. L., Hayakawa, Y., Urbanska, A. M., Quante, M., Reichert, M., Broyde, J. & Subramaniam, P. S. & 9 others, Remotti, H., Su, G. H., Rustgi, A. K., Friedman, R. A., Honig, B., Califano, A., Houchen, C. W., Olive, K. P. & Wang, T. C., 7 Apr 2016, In: Cell Stem Cell. 18, 4, p. 441-455 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

178 Scopus citations

ETS-Transcription Factor ETV1 Regulates Stromal Expansion and Metastasis in Pancreatic Cancer

Heeg, S., Das, K. K., Reichert, M., Bakir, B., Takano, S., Caspers, J., Aiello, N. M., Wu, K., Neesse, A., Maitra, A., Iacobuzio-Donahue, C. A., Hicks, P. & Rustgi, A. K., 1 Sep 2016, In: Gastroenterology. 151, 3, p. 540-553.e14

Research output: Contribution to journal › Article › peer-review

Open Access

52 Scopus citations

Membranous CD24 drives the epithelial phenotype of pancreatic cancer

Lubeseder-Martellato, C., Hidalgo-Sastre, A., Hartmann, C., Alexandrow, K., Kamyabi-Moghaddam, Z., Sipos, B., Wirth, M., Neff, F., Reichert, M., Heid, I., Schneider, G., Braren, R., Schmid, R. M. & Siveke, J. T., 2016, In: Oncotarget. 7, 31, p. 49156-49168 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

19 Scopus citations

Prrx1 isoform switching regulates pancreatic cancer invasion and metastatic colonization

Takano, S., Reichert, M., Bakir, B., Das, K. K., Nishida, T., Miyazaki, M., Heeg, S., Collins, M. A., Marchand, B., Hicks, P. D., Maitra, A. & Rustgi, A. K., 15 Jan 2016, In: Genes and Development. 30, 2, p. 233-247 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

97 Scopus citations

2015

Detection of tumor suppressor genes in cancer development by a novel shRNA-based method

Von Burstin, J., Diersch, S., Schneider, G., Reichert, M., Rustgi, A. K. & Schmid, R. M., 1 May 2015, In: Molecular Cancer Research. 13, 5, p. 863-869 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Scopus citations

2009

PI3K signaling maintains c-myc expression to regulate transcription of E2F1 in pancreatic cancer cells

Schild, C., Wirth, M., Reichert, M., Schmid, R. M., Saur, D. & Schneider, G., Dec 2009, In: Molecular Carcinogenesis. 48, 12, p. 1149-1158 10 p.

Research output: Contribution to journal › Article › peer-review

56 Scopus citations

2007

Casein kinase II inhibition induces apoptosis in pancreatic cancer cells

Hamacher, R., Saur, D., Fritsch, R., Reichert, M., Schmid, R. M. & Schneider, G., Sep 2007, In: Oncology Reports. 18, 3, p. 695-701 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

41 Scopus citations

HDAC3 is linked to cell cycle machinery in MiaPaCa2 cells by regulating transcription of skp2

Schneider, G., Reichert, M., Saur, D., Hamacher, R., Fritsch, R. & Schmid, R. M., Aug 2007, In: Cell Proliferation. 40, 4, p. 522-531 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

10 Scopus citations

HMGA1 controls transcription of insulin receptor to regulate cyclin D1 translation in pancreatic cancer cells

Kolb, S., Fritsch, R., Saur, D., Reichert, M., Schmid, R. M. & Schneider, G., 15 May 2007, In: Cancer Research. 67, 10, p. 4679-4686 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

35 Scopus citations

Phosphoinositide-3-kinase signaling controls S-phase kinase-associated protein 2 transcription via E2F1 in pancreatic ductal adenocarcinoma cells

Reichert, M., Saur, D., Hamacher, R., Schmid, R. M. & Schneider, G., 1 May 2007, In: Cancer Research. 67, 9, p. 4149-4156 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

98 Scopus citations

Associate Professorship of Translationale Pankreaskrebsforschung

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