Research output per year
Research output per year
- 41 results
Search results
-
2025
An atypical atherogenic chemokine that promotes advanced atherosclerosis and hepatic lipogenesis
El Bounkari, O., Zan, C., Yang, B., Ebert, S., Wagner, J., Bugar, E., Kramer, N., Bourilhon, P., Kontos, C., Zarwel, M., Sinitski, D., Milic, J., Jansen, Y., Kempf, W. E., Sachs, N., Maegdefessel, L., Ji, H., Gokce, O., Riols, F. & Haid, M. & 17 others, , Dec 2025, In: Nature Communications. 16, 1, 2297.Research output: Contribution to journal › Article › peer-review
Open Access -
Multi-Targeting Macrocyclic Peptides as Nanomolar Inhibitors of Self- and Cross-Seeded Amyloid Self-Assembly of α-Synuclein
Hornung, S., Vogl, D. P., Naltsas, D., Volta, B. D., Ballmann, M., Marcon, B., Syed, M. M. K., Wu, Y., Spanopoulou, A., Feederle, R., Heidrich, L., Bernhagen, J., Koeglsperger, T., Höglinger, G. U., Rammes, G., Lashuel, H. A. & Kapurniotu, A., 1 Apr 2025, In: Angewandte Chemie International Edition in English. 64, 14, e202422834.Research output: Contribution to journal › Article › peer-review
Open Access -
Multi-Targeting Macrocyclic Peptides as Nanomolar Inhibitors of Self- and Cross-Seeded Amyloid Self-Assembly of α-Synuclein
Hornung, S., Vogl, D. P., Naltsas, D., Volta, B. D., Ballmann, M., Marcon, B., Syed, M. M. K., Wu, Y., Spanopoulou, A., Feederle, R., Heidrich, L., Bernhagen, J., Koeglsperger, T., Höglinger, G. U., Rammes, G., Lashuel, H. A. & Kapurniotu, A., 1 Apr 2025, In: Angewandte Chemie International Edition in English. 64, 14, e202422834.Research output: Contribution to journal › Article › peer-review
Open Access -
2024
Modulation of Alzheimer’s Disease Aβ40 Fibril Polymorphism by the Small Heat Shock Protein αB-Crystallin
Rodina, N., Hornung, S., Sarkar, R., Suladze, S., Peters, C., Schmid, P. W. N., Niu, Z., Haslbeck, M., Buchner, J., Kapurniotu, A. & Reif, B., 17 Jul 2024, In: Journal of the American Chemical Society. 146, 28, p. 19077-19087 11 p.Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations -
2023
Lasso-grafted designer cytokines
Kapurniotu, A. & Bernhagen, J., Feb 2023, In: Nature Biomedical Engineering. 7, 2, p. 89-91 3 p.Research output: Contribution to journal › Article › peer-review
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Macrophage migration inhibitory factor (MIF) and its homolog D-dopachrome tautomerase (D-DT) are significant promotors of UVB- but not chemically induced non-melanoma skin cancer
Huth, S., Huth, L., Heise, R., Marquardt, Y., Lopopolo, L., Piecychna, M., Boor, P., Fingerle-Rowson, G., Kapurniotu, A., Yazdi, A. S., Bucala, R., Bernhagen, J. & Baron, J. M., Dec 2023, In: Scientific Reports. 13, 1, 11611.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
Pathways linking aging and atheroprotection in Mif-deficient atherosclerotic mice
Krammer, C., Yang, B., Reichl, S., Besson-Girard, S., Ji, H., Bolini, V., Schulte, C., Noels, H., Schlepckow, K., Jocher, G., Werner, G., Willem, M., El Bounkari, O., Kapurniotu, A., Gokce, O., Weber, C., Mohanta, S. & Bernhagen, J., Mar 2023, In: FASEB Journal. 37, 3, e22752.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
2022
Designed peptides as nanomolar cross-amyloid inhibitors acting via supramolecular nanofiber co-assembly
Taş, K., Volta, B. D., Lindner, C., El Bounkari, O., Hille, K., Tian, Y., Puig-Bosch, X., Ballmann, M., Hornung, S., Ortner, M., Prem, S., Meier, L., Rammes, G., Haslbeck, M., Weber, C., Megens, R. T. A., Bernhagen, J. & Kapurniotu, A., Dec 2022, In: Nature Communications. 13, 1, 5004.Research output: Contribution to journal › Article › peer-review
Open Access28 Scopus citations -
Heterocomplexes between the atypical chemokine MIF and the CXC-motif chemokine CXCL4L1 regulate inflammation and thrombus formation
Brandhofer, M., Hoffmann, A., Blanchet, X., Siminkovitch, E., Rohlfing, A. K., El Bounkari, O., Nestele, J. A., Bild, A., Kontos, C., Hille, K., Rohde, V., Fröhlich, A., Golemi, J., Gokce, O., Krammer, C., Scheiermann, P., Tsilimparis, N., Sachs, N., Kempf, W. E. & Maegdefessel, L. & 12 others, , Oct 2022, In: Cellular and Molecular Life Sciences. 79, 10, 512.Research output: Contribution to journal › Article › peer-review
Open Access12 Scopus citations -
2021
A MIF-Derived Cyclopeptide that Inhibits MIF Binding and Atherogenic Signaling via the Chemokine Receptor CXCR2
Krammer, C., Kontos, C., Dewor, M., Hille, K., Dalla Volta, B., El Bounkari, O., Taş, K., Sinitski, D., Brandhofer, M., Megens, R. T. A., Weber, C., Schultz, J. R., Bernhagen, J. & Kapurniotu, A., 16 Mar 2021, In: ChemBioChem. 22, 6, p. 1012-1019 8 p.Research output: Contribution to journal › Article › peer-review
Open Access9 Scopus citations -
2020
Cross-kingdom mimicry of the receptor signaling and leukocyte recruitment activity of a human cytokine by its plant orthologs
Sinitski, D., Gruner, K., Brandhofer, M., Kontos, C., Winkler, P., Reinstädler, A., Bourilhon, P., Xiao, Z., Cool, R., Kapurniotu, A., Dekker, F. J., Panstruga, R. & Bernhagen, J., 17 Jan 2020, In: Journal of Biological Chemistry. 295, 3, p. 850-867 18 p.Research output: Contribution to journal › Article › peer-review
Open Access8 Scopus citations -
Designed CXCR4 mimic acts as a soluble chemokine receptor that blocks atherogenic inflammation by agonist-specific targeting
Kontos, C., El Bounkari, O., Krammer, C., Sinitski, D., Hille, K., Zan, C., Yan, G., Wang, S., Gao, Y., Brandhofer, M., Megens, R. T. A., Hoffmann, A., Pauli, J., Asare, Y., Gerra, S., Bourilhon, P., Leng, L., Eckstein, H. H., Kempf, W. E. & Pelisek, J. & 7 others, , Dec 2020, In: Nature Communications. 11, 1, 5981.Research output: Contribution to journal › Article › peer-review
Open Access34 Scopus citations -
Structural Insight into IAPP-Derived Amyloid Inhibitors and Their Mechanism of Action
Niu, Z., Prade, E., Malideli, E., Hille, K., Jussupow, A., Mideksa, Y. G., Yan, L. M., Qian, C., Fleisch, M., Messias, A. C., Sarkar, R., Sattler, M., Lamb, D. C., Feige, M. J., Camilloni, C., Kapurniotu, A. & Reif, B., 27 Mar 2020, In: Angewandte Chemie International Edition in English. 59, 14, p. 5771-5781 11 p.Research output: Contribution to journal › Article › peer-review
Open Access19 Scopus citations -
The Human Host-Defense Peptide Cathelicidin LL-37 is a Nanomolar Inhibitor of Amyloid Self-Assembly of Islet Amyloid Polypeptide (IAPP)
Armiento, V., Hille, K., Naltsas, D., Lin, J. S., Barron, A. E. & Kapurniotu, A., 27 Jul 2020, In: Angewandte Chemie International Edition in English. 59, 31, p. 12837-12841 5 p.Research output: Contribution to journal › Article › peer-review
Open Access36 Scopus citations -
2019
Blocking Inflammasome Activation Caused by β-Amyloid Peptide (Aβ) and Islet Amyloid Polypeptide (IAPP) through an IAPP Mimic
Aftabizadeh, M., Tatarek-Nossol, M., Andreetto, E., El Bounkari, O., Kipp, M., Beyer, C., Latz, E., Bernhagen, J. & Kapurniotu, A., 21 Aug 2019, In: ACS Chemical Neuroscience. 10, 8, p. 3703-3717 15 p.Research output: Contribution to journal › Article › peer-review
19 Scopus citations -
Macrophage Migration Inhibitory Factor (MIF)-Based Therapeutic Concepts in Atherosclerosis and Inflammation
Sinitski, D., Kontos, C., Krammer, C., Asare, Y., Kapurniotu, A. & Bernhagen, J., 2019, In: Thrombosis and Haemostasis. 119, 4, p. 553-566 14 p.Research output: Contribution to journal › Article › peer-review
Open Access68 Scopus citations -
2018
Designed Macrocyclic Peptides as Nanomolar Amyloid Inhibitors Based on Minimal Recognition Elements
Spanopoulou, A., Heidrich, L., Chen, H. R., Frost, C., Hrle, D., Malideli, E., Hille, K., Grammatikopoulos, A., Bernhagen, J., Zacharias, M., Rammes, G. & Kapurniotu, A., 26 Oct 2018, In: Angewandte Chemie International Edition in English. 57, 44, p. 14503-14508 6 p.Research output: Contribution to journal › Article › peer-review
41 Scopus citations -
Identification of an Arg-Leu-Arg tripeptide that contributes to the binding interface between the cytokine MIF and the chemokine receptor CXCR4
Lacy, M., Kontos, C., Brandhofer, M., Hille, K., Gröning, S., Sinitski, D., Bourilhon, P., Rosenberg, E., Krammer, C., Thavayogarajah, T., Pantouris, G., Bakou, M., Weber, C., Lolis, E., Bernhagen, J. & Kapurniotu, A., 1 Dec 2018, In: Scientific Reports. 8, 1, 5171.Research output: Contribution to journal › Article › peer-review
Open Access42 Scopus citations -
LPS-mediated cell surface expression of CD74 promotes the proliferation of B cells in response to MIF
Klasen, C., Ziehm, T., Huber, M., Asare, Y., Kapurniotu, A., Shachar, I., Bernhagen, J. & El Bounkari, O., Jun 2018, In: Cellular Signalling. 46, p. 32-42 11 p.Research output: Contribution to journal › Article › peer-review
29 Scopus citations -
Mif-deficiency favors an atheroprotective autoantibody phenotype in atherosclerosis
Schmitz, C., Noels, H., El Bounkari, O., Straussfeld, E., Megens, R. T. A., Sternkopf, M., Alampour-Rajabi, S., Krammer, C., Tilstam, P. V., Gerdes, N., Bürger, C., Kapurniotu, A., Bucala, R., Jankowski, J., Weber, C. & Bernhagen, J., Aug 2018, In: FASEB Journal. 32, 8, p. 4428-4443 16 p.Research output: Contribution to journal › Article › peer-review
Open Access23 Scopus citations -
2017
Key aromatic/hydrophobic amino acids controlling a cross-amyloid peptide interaction versus amyloid self-assembly
Bakou, M., Hille, K., Kracklauer, M., Spanopoulou, A., Frost, C. V., Malideli, E., Yan, L. M., Caporale, A., Zacharias, M. & Kapurniotu, A., 1 Sep 2017, In: Journal of Biological Chemistry. 292, 35, p. 14587-14602 16 p.Research output: Contribution to journal › Article › peer-review
Open Access48 Scopus citations -
2016
Macrophage migration inhibitory factor-CXCR4 receptor interactions: Evidence for partial allosteric agonism in comparison with CXCL12 chemokine
Rajasekaran, D., Gröning, S., Schmitz, C., Zierow, S., Drucker, N., Bakou, M., Kohl, K., Mertens, A., Lue, H., Weber, C., Xiao, A., Luker, G., Kapurniotu, A., Lolis, E. & Bernhagen, J., 22 Jul 2016, In: Journal of Biological Chemistry. 291, 30, p. 15881-15895 15 p.Research output: Contribution to journal › Article › peer-review
Open Access66 Scopus citations -
Peptide Inhibitors of the amyloidogenesis of IAPP: verification of the hairpin-binding geometry hypothesis
Sivanesam, K., Shu, I., Huggins, K. N. L., Tatarek-Nossol, M., Kapurniotu, A. & Andersen, N. H., 1 Aug 2016, In: FEBS Letters. p. 2575-2583 9 p.Research output: Contribution to journal › Article › peer-review
Open Access27 Scopus citations -
2015
A Hot-Segment-Based Approach for the Design of Cross-Amyloid Interaction Surface Mimics as Inhibitors of Amyloid Self-Assembly
Andreetto, E., Malideli, E., Yan, L. M., Kracklauer, M., Farbiarz, K., Tatarek-Nossol, M., Rammes, G., Prade, E., Neumüller, T., Caporale, A., Spanopoulou, A., Bakou, M., Reif, B. & Kapurniotu, A., 1 Oct 2015, In: Angewandte Chemie International Edition in English. 54, 44, p. 13095-13100 6 p.Research output: Contribution to journal › Article › peer-review
55 Scopus citations -
2014
Development of accessible peptidic tool compounds to study the phosphatase PTP1B in intact cells
Meyer, C., Hoeger, B., Temmerman, K., Tatarek-Nossol, M., Pogenberg, V., Bernhagen, J., Wilmanns, M., Kapurniotu, A. & Köhn, M., 21 Mar 2014, In: ACS Chemical Biology. 9, 3, p. 769-776 8 p.Research output: Contribution to journal › Article › peer-review
21 Scopus citations -
Molecular characterization of the hetero-assembly of β-amyloid peptide with islet
Yan, L. M., Velkova, A. & Kapurniotu, A., 2014, In: Current Pharmaceutical Design. 20, 8, p. 1182-1191 10 p.Research output: Contribution to journal › Article › peer-review
33 Scopus citations -
2013
Selectively N-methylated soluble IAPP mimics as potent IAPP receptor agonists and nanomolar inhibitors of cytotoxic self-assembly of both IAPP and Aβ40
Yan, L. M., Velkova, A., Tatarek-Nossol, M., Rammes, G., Sibaev, A., Andreetto, E., Kracklauer, M., Bakou, M., Malideli, E., Göke, B., Schirra, J., Storr, M. & Kapurniotu, A., 23 Sep 2013, In: Angewandte Chemie International Edition in English. 52, 39, p. 10378-10383 6 p.Research output: Contribution to journal › Article › peer-review
43 Scopus citations -
The backbone dynamics of the amyloid precursor protein transmembrane helix provides a rationale for the sequential cleavage mechanism of γ-secretase
Pester, O., Barrett, P. J., Hornburg, D., Hornburg, P., Pröbstle, R., Widmaier, S., Kutzner, C., Dürrbaum, M., Kapurniotu, A., Sanders, C. R., Scharnagl, C. & Langosch, D., 30 Jan 2013, In: Journal of the American Chemical Society. 135, 4, p. 1317-1329 13 p.Research output: Contribution to journal › Article › peer-review
Open Access65 Scopus citations -
2012
Cross-amyloid interaction of Aβ and IAPP at lipid membranes
Seeliger, J., Evers, F., Jeworrek, C., Kapoor, S., Weise, K., Andreetto, E., Tolan, M., Kapurniotu, A. & Winter, R., 16 Jan 2012, In: Angewandte Chemie International Edition in English. 51, 3, p. 679-683 5 p.Research output: Contribution to journal › Article › peer-review
70 Scopus citations -
Strategien zur inhibition der protein - aggregation bei amyloidkrankheiten
Translated title of the contribution :Molecular medicine: Strategies for the inhibition of protein aggregation in amyloid diseases Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
2011
Designed hairpin peptides interfere with amyloidogenesis pathways: Fibril formation and cytotoxicity inhibition, interception of the preamyloid state
Huggins, K. N. L., Bisaglia, M., Bubacco, L., Tatarek-Nossol, M., Kapurniotu, A. & Andersen, N. H., 27 Sep 2011, In: Biochemistry. 50, 38, p. 8202-8212 11 p.Research output: Contribution to journal › Article › peer-review
Open Access51 Scopus citations -
Dissecting the Role of Single Regions of an IAPP Mimic and IAPP in Inhibition of Aβ40 Amyloid Formation and Cytotoxicity
Andreetto, E., Yan, L. M., Caporale, A. & Kapurniotu, A., 14 Jun 2011, In: ChemBioChem. 12, 9, p. 1313-1322 10 p.Research output: Contribution to journal › Article › peer-review
35 Scopus citations -
Interaction between amyloid beta peptide and an aggregation blocker peptide mimicking islet amyloid polypeptide
Rezaei-Ghaleh, N., Andreetto, E., Yan, L. M., Kapurniotu, A. & Zweckstetter, M., 2011, In: PLoS ONE. 6, 5, e20289.Research output: Contribution to journal › Article › peer-review
Open Access45 Scopus citations -
MIF-chemokine receptor interactions in atherogenesis are dependent on an N-loop-based 2-site binding mechanism
Kraemer, S., Lue, H., Zernecke, A., Kapurniotu, A., Andreetto, E., Frank, R., Lennartz, B., Weber, C. & Bernhagen, J., Mar 2011, In: FASEB Journal. 25, 3, p. 894-906 13 p.Research output: Contribution to journal › Article › peer-review
46 Scopus citations -
Terminating the amyloid zipper by design
Kapurniotu, A., 25 Nov 2011, In: Angewandte Chemie International Edition in English. 50, 48, p. 11293-11294 2 p.Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
2010
Identification of hot regions of the Aβ-IAPP Interaction interface as high-affinity binding sites in both cross- and self-association
Andreetto, E., Yan, L. M., Tatarek-Nossol, M., Velkova, A., Frank, R. & Kapurniotu, A., 12 Apr 2010, In: Angewandte Chemie International Edition in English. 49, 17, p. 3081-3085 5 p.Research output: Contribution to journal › Article › peer-review
174 Scopus citations -
Suppression of IAPP fibrillation at anionic lipid membranes via IAPP-derived amyloid inhibitors and insulin
Sellin, D., Yan, L. M., Kapurniotu, A. & Winter, R., Aug 2010, In: Biophysical Chemistry. 150, 1-3, p. 73-79 7 p.Research output: Contribution to journal › Article › peer-review
67 Scopus citations -
2008
Exploiting cross-amyloid interactions to inhibit protein aggregation but not function: Nanomolar affinity inhibition of insulin aggregation by an IAPP mimic
Velkova, A., Tatarek-Nossol, M., Andreetto, E. & Kapurniotu, A., 1 Sep 2008, In: Angewandte Chemie International Edition in English. 47, 37, p. 7114-7118 5 p.Research output: Contribution to journal › Article › peer-review
36 Scopus citations -
Structural determinants of MIF functions in CXCR2-mediated inflammatory and atherogenic leukocyte recruitment
Weber, C., Kraemer, S., Drechsler, M., Lue, H., Koenen, R. R., Kapurniotu, A., Zernecke, A. & Bernhagen, J., 21 Oct 2008, In: Proceedings of the National Academy of Sciences of the United States of America. 105, 42, p. 16278-16283 6 p.Research output: Contribution to journal › Article › peer-review
Open Access140 Scopus citations -
1999
Advanced glycation end products: Detection and reversal
Al-Abed, Y., Kapurniotu, A. & Bucala, R., 1999, In: Methods in Enzymology. 309, p. 152-172 21 p.Research output: Contribution to journal › Article › peer-review
37 Scopus citations -
Characterization of catalytic centre mutants of macrophage migration inhibitory factor (MIF) and comparison to Cys81Ser MIF
Kleemann, R., Kapurniotu, A., Mischke, R., Held, J. & Bernhagen, J., 1 May 1999, In: European Journal of Biochemistry. 261, 3, p. 753-766 14 p.Research output: Contribution to journal › Article › peer-review
54 Scopus citations