Associate Professorship of Experimental Hematology

2025

ARID1A mutations protect follicular lymphoma from FAS-dependent immune surveillance by reducing RUNX3/ETS1-driven FAS-expression

Antoniolli, M., Solovey, M., Hildebrand, J. A., Freyholdt, T., Strobl, C. D., Bararia, D., Keay, W. D., Adolph, L., Heide, M., Passerini, V., Winter, L., Wange, L., Enard, W., Thieme, S., Blum, H., Rudelius, M., Mergner, J., Ludwig, C., Bultmann, S. & Schmidt-Supprian, M. & 5 others, Leonhardt, H., Subklewe, M., von Bergwelt-Baildon, M., Colomé-Tatché, M. & Weigert, O., 2025, (Accepted/In press) In: Cell Death and Differentiation. 109943.

Research output: Contribution to journal › Article › peer-review

Open Access

NK cell-derived IFNγ mobilizes free fatty acids from adipose tissue to promote early B cell activation during viral infection

Krapić, M., Kavazović, I., Mikašinović, S., Mladenić, K., Krstanović, F., Seyhan, G., Helmrath, S., Camerini, E., Brizić, I., Peters, F. S., Schmidt-Supprian, M., Polić, B., Turk Wensveen, T. & Wensveen, F. M., 2025, (Accepted/In press) In: Nature Metabolism. 14210.

Research output: Contribution to journal › Article › peer-review

2024

B cells orchestrate tolerance to the neuromyelitis optica autoantigen AQP4

Afzali, A. M., Nirschl, L., Sie, C., Pfaller, M., Ulianov, O., Hassler, T., Federle, C., Petrozziello, E., Kalluri, S. R., Chen, H. H., Tyystjärvi, S., Muschaweckh, A., Lammens, K., Delbridge, C., Büttner, A., Steiger, K., Seyhan, G., Ottersen, O. P., Öllinger, R. & Rad, R. & 16 others, Jarosch, S., Straub, A., Mühlbauer, A., Grassmann, S., Hemmer, B., Böttcher, J. P., Wagner, I., Kreutzfeldt, M., Merkler, D., Pardàs, I. B., Schmidt Supprian, M., Buchholz, V. R., Heink, S., Busch, D. H., Klein, L. & Korn, T., 14 Mar 2024, In: Nature. 627, 8003, p. 407-415 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

21 Scopus citations

Genome-scale pan-cancer interrogation of lncRNA dependencies using CasRx

Montero, J. J., Trozzo, R., Sugden, M., Öllinger, R., Belka, A., Zhigalova, E., Waetzig, P., Engleitner, T., Schmidt-Supprian, M., Saur, D. & Rad, R., Apr 2024, In: Nature Methods. 21, 4, p. 584-596 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

12 Scopus citations

NF-κB subunits RelA and c-Rel selectively control CD4⁺ T cell function in multiple sclerosis and cancer

Lalle, G., Lautraite, R., Bouherrou, K., Plaschka, M., Pignata, A., Voisin, A., Twardowski, J., Perrin-Niquet, M., Stéphan, P., Durget, S., Tonon, L., Ardin, M., Degletagne, C., Viari, A., Dutron, L. B., Davoust, N., Postler, T. S., Zhao, J., Caux, C. & Caramel, J. & 7 others, Dalle, S., Cassier, P. A., Klein, U., Schmidt-Supprian, M., Liblau, R., Ghosh, S. & Grinberg-Bleyer, Y., 3 Jun 2024, In: Journal of Experimental Medicine. 221, 6, e20231348.

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Notch2 controls developmental fate choices between germinal center and marginal zone B cells upon immunization

Babushku, T., Lechner, M., Ehrenberg, S., Rambold, U., Schmidt-Supprian, M., Yates, A. J., Rane, S., Zimber-Strobl, U. & Strobl, L. J., Dec 2024, In: Nature Communications. 15, 1, 1960.

Research output: Contribution to journal › Article › peer-review

Open Access

8 Scopus citations

2023

A20 and the noncanonical NF-κB pathway are key regulators of neutrophil recruitment during fetal ontogeny

Rohwedder, I., Wackerbarth, L. M., Heinig, K., Ballweg, A., Altstätter, J., Ripphahn, M., Nussbaum, C., Salvermoser, M., Bierschenk, S., Straub, T., Gunzer, M., Schmidt-Supprian, M., Kolben, T., Schulz, C., Ma, A., Walzog, B., Heinig, M. & Sperandio, M., 22 Feb 2023, In: JCI Insight. 8, 4, e155968.

Research output: Contribution to journal › Article › peer-review

Open Access

7 Scopus citations

An integrated cellular and molecular model of gastric neuroendocrine cancer evolution highlights therapeutic targets

Griger, J., Widholz, S. A., Jesinghaus, M., de Andrade Krätzig, N., Lange, S., Engleitner, T., Montero, J. J., Zhigalova, E., Öllinger, R., Suresh, V., Winkler, W., Lier, S., Baranov, O., Trozzo, R., Ben Khaled, N., Chakraborty, S., Yu, J., Konukiewitz, B., Steiger, K. & Pfarr, N. & 16 others, Rajput, A., Sailer, D., Keller, G., Schirmacher, P., Röcken, C., Fagerstedt, K. W., Mayerle, J., Schmidt-Supprian, M., Schneider, G., Weichert, W., Calado, D. P., Sommermann, T., Klöppel, G., Rajewsky, K., Saur, D. & Rad, R., 10 Jul 2023, In: Cancer Cell. 41, 7, p. 1327-1344.e10

Research output: Contribution to journal › Article › peer-review

Open Access

14 Scopus citations

AP1/Fra1 confers resistance to MAPK cascade inhibition in pancreatic cancer

Schneeweis, C., Diersch, S., Hassan, Z., Krauß, L., Schneider, C., Lucarelli, D., Falcomatà, C., Steiger, K., Öllinger, R., Krämer, O. H., Arlt, A., Grade, M., Schmidt-Supprian, M., Hessmann, E., Wirth, M., Rad, R., Reichert, M., Saur, D. & Schneider, G., Jan 2023, In: Cellular and Molecular Life Sciences. 80, 1, 12.

Research output: Contribution to journal › Article › peer-review

Open Access

7 Scopus citations

Context-Specific Determinants of the Immunosuppressive Tumor Microenvironment in Pancreatic Cancer

Falcomatà, C., Bärthel, S., Schneider, G., Rad, R., Schmidt-Supprian, M. & Saur, D., 1 Feb 2023, In: Cancer Discovery. 13, 2, p. 278-297 20 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

98 Scopus citations

In vivo interrogation of regulatory genomes reveals extensive quasi-insufficiency in cancer evolution

Fischer, A., Lersch, R., de Andrade Krätzig, N., Strong, A., Friedrich, M. J., Weber, J., Engleitner, T., Öllinger, R., Yen, H. Y., Kohlhofer, U., Gonzalez-Menendez, I., Sailer, D., Kogan, L., Lahnalampi, M., Laukkanen, S., Kaltenbacher, T., Klement, C., Rezaei, M., Ammon, T. & Montero, J. J. & 16 others, Schneider, G., Mayerle, J., Heikenwälder, M., Schmidt-Supprian, M., Quintanilla-Martinez, L., Steiger, K., Liu, P., Cadiñanos, J., Vassiliou, G. S., Saur, D., Lohi, O., Heinäniemi, M., Conte, N., Bradley, A., Rad, L. & Rad, R., 8 Mar 2023, In: Cell Genomics. 3, 3, 100276.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

Slow integrin-dependent migration organizes networks of tissue-resident mast cells

Kaltenbach, L., Martzloff, P., Bambach, S. K., Aizarani, N., Mihlan, M., Gavrilov, A., Glaser, K. M., Stecher, M., Thünauer, R., Thiriot, A., Heger, K., Kierdorf, K., Wienert, S., von Andrian, U. H., Schmidt-Supprian, M., Nerlov, C., Klauschen, F., Roers, A., Bajénoff, M. & Grün, D. & 1 others, Lämmermann, T., Jun 2023, In: Nature Immunology. 24, 6, p. 915-924 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

22 Scopus citations

2022

CRISPR somatic genome engineering and cancer modeling in the mouse pancreas and liver

Kaltenbacher, T., Löprich, J., Maresch, R., Weber, J., Müller, S., Oellinger, R., Groß, N., Griger, J., de Andrade Krätzig, N., Avramopoulos, P., Ramanujam, D., Brummer, S., Widholz, S. A., Bärthel, S., Falcomatà, C., Pfaus, A., Alnatsha, A., Mayerle, J., Schmidt-Supprian, M. & Reichert, M. & 6 others, Schneider, G., Ehmer, U., Braun, C. J., Saur, D., Engelhardt, S. & Rad, R., Apr 2022, In: Nature Protocols. 17, 4, p. 1142-1188 47 p.

Research output: Contribution to journal › Review article › peer-review

15 Scopus citations

Neutrophil “plucking” on megakaryocytes drives platelet production and boosts cardiovascular disease

Petzold, T., Zhang, Z., Ballesteros, I., Saleh, I., Polzin, A., Thienel, M., Liu, L., Ul Ain, Q., Ehreiser, V., Weber, C., Kilani, B., Mertsch, P., Götschke, J., Cremer, S., Fu, W., Lorenz, M., Ishikawa-Ankerhold, H., Raatz, E., El-Nemr, S. & Görlach, A. & 12 others, Marhuenda, E., Stark, K., Pircher, J., Stegner, D., Gieger, C., Schmidt-Supprian, M., Gaertner, F., Almendros, I., Kelm, M., Schulz, C., Hidalgo, A. & Massberg, S., 13 Dec 2022, In: Immunity. 55, 12, p. 2285-2299.e7

Research output: Contribution to journal › Article › peer-review

Open Access

47 Scopus citations

NF-κB in control of regulatory T cell development, identity, and function

Hövelmeyer, N., Schmidt-Supprian, M. & Ohnmacht, C., Jul 2022, In: Journal of Molecular Medicine. 100, 7, p. 985-995 11 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

22 Scopus citations

PARP14 is a novel target in STAT6 mutant follicular lymphoma

Mentz, M., Keay, W., Strobl, C. D., Antoniolli, M., Adolph, L., Heide, M., Lechner, A., Haebe, S., Osterode, E., Kridel, R., Ziegenhain, C., Wange, L. E., Hildebrand, J. A., Shree, T., Silkenstedt, E., Staiger, A. M., Ott, G., Horn, H., Szczepanowski, M. & Richter, J. & 12 others, Levy, R., Rosenwald, A., Enard, W., Zimber-Strobl, U., von Bergwelt-Baildon, M., Hiddemann, W., Klapper, W., Schmidt-Supprian, M., Rudelius, M., Bararia, D., Passerini, V. & Weigert, O., Sep 2022, In: Leukemia. 36, 9, p. 2281-2292 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

14 Scopus citations

Selective multi-kinase inhibition sensitizes mesenchymal pancreatic cancer to immune checkpoint blockade by remodeling the tumor microenvironment

Falcomatà, C., Bärthel, S., Widholz, S. A., Schneeweis, C., Montero, J. J., Toska, A., Mir, J., Kaltenbacher, T., Heetmeyer, J., Swietlik, J. J., Cheng, J. Y., Teodorescu, B., Reichert, O., Schmitt, C., Grabichler, K., Coluccio, A., Boniolo, F., Veltkamp, C., Zukowska, M. & Vargas, A. A. & 17 others, Paik, W. H., Jesinghaus, M., Steiger, K., Maresch, R., Öllinger, R., Ammon, T., Baranov, O., Robles, M. S., Rechenberger, J., Kuster, B., Meissner, F., Reichert, M., Flossdorf, M., Rad, R., Schmidt-Supprian, M., Schneider, G. & Saur, D., Mar 2022, In: Nature Cancer. 3, 3, p. 318-336 19 p.

Research output: Contribution to journal › Article › peer-review

Open Access

64 Scopus citations

2021

Brief homogeneous TCR signals instruct common iNKT progenitors whose effector diversification is characterized by subsequent cytokine signaling

Bortoluzzi, S., Dashtsoodol, N., Engleitner, T., Drees, C., Helmrath, S., Mir, J., Toska, A., Flossdorf, M., Öllinger, R., Solovey, M., Colomé-Tatché, M., Kalfaoglu, B., Ono, M., Buch, T., Ammon, T., Rad, R. & Schmidt-Supprian, M., 9 Nov 2021, In: Immunity. 54, 11, p. 2497-2513.e9

Research output: Contribution to journal › Article › peer-review

Open Access

24 Scopus citations

Cerebral angiogenesis ameliorates pathological disorders in Nemo-deficient mice with small-vessel disease

Jiang, Y., Müller, K., Khan, M. A., Assmann, J. C., Lampe, J., Kilau, K., Richter, M., Kleint, M., Ridder, D. A., Hübner, N., Schmidt-Supprian, M., Wenzel, J. & Schwaninger, M., Feb 2021, In: Journal of Cerebral Blood Flow and Metabolism. 41, 2, p. 219-235 17 p.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Scopus citations

Differences in cell-intrinsic inflammatory programs of yolk sac and bone marrow macrophages

Elhag, S., Stremmel, C., Zehrer, A., Plocke, J., Hennel, R., Keuper, M., Knabe, C., Winterhalter, J., Gölling, V., Tomas, L., Weinberger, T., Fischer, M., Liu, L., Wagner, F., Lorenz, M., Stark, K., Häcker, H., Schmidt-Supprian, M., Völker, U. & Jastroch, M. & 5 others, Lauber, K., Straub, T., Walzog, B., Hammer, E. & Schulz, C., Dec 2021, In: Cells. 10, 12, 3564.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Scopus citations

Genetic screens identify a context-specific pi3k/p27^kip1 node driving extrahepatic biliary cancer

Falcomatà, C., Bärthel, S., Ulrich, A., Diersch, S., Veltkamp, C., Rad, L., Boniolo, F., Solar, M., Steiger, K., Seidler, B., Zukowska, M., Madej, J., Wang, M., Öllinger, R., Maresch, R., Barenboim, M., Eser, S., Tschurtschenthaler, M., Mehrabi, A. & Roessler, S. & 14 others, Goeppert, B., Kind, A., Schnieke, A., Robles, M. S., Bradley, A., Schmid, R. M., Schmidt-Supprian, M., Reichert, M., Weichert, W., Sansom, O. J., Morton, J. P., Rad, R., Schneider, G. & Saur, D., Dec 2021, In: Cancer Discovery. 11, 12, p. 3158-3177 20 p.

Research output: Contribution to journal › Article › peer-review

Open Access

13 Scopus citations

In vivo inducible reverse genetics in patients’ tumors to identify individual therapeutic targets

Carlet, M., Völse, K., Vergalli, J., Becker, M., Herold, T., Arner, A., Senft, D., Jurinovic, V., Liu, W. H., Gao, Y., Dill, V., Fehse, B., Baldus, C. D., Bastian, L., Lenk, L., Schewe, D. M., Bagnoli, J. W., Vick, B., Schmid, J. P. & Wilhelm, A. & 7 others, Marschalek, R., Jost, P. J., Miething, C., Riecken, K., Schmidt-Supprian, M., Binder, V. & Jeremias, I., 1 Dec 2021, In: Nature Communications. 12, 1, 5655.

Research output: Contribution to journal › Article › peer-review

Open Access

10 Scopus citations

Notch2-mediated plasticity between marginal zone and follicular B cells

Lechner, M., Engleitner, T., Babushku, T., Schmidt-Supprian, M., Rad, R., Strobl, L. J. & Zimber-Strobl, U., 1 Dec 2021, In: Nature Communications. 12, 1, 1111.

Research output: Contribution to journal › Article › peer-review

Open Access

35 Scopus citations

2020

Cathepsin S Alterations Induce a Tumor-Promoting Immune Microenvironment in Follicular Lymphoma

Bararia, D., Hildebrand, J. A., Stolz, S., Haebe, S., Alig, S., Trevisani, C. P., Osorio-Barrios, F., Bartoschek, M. D., Mentz, M., Pastore, A., Gaitzsch, E., Heide, M., Jurinovic, V., Rautter, K., Gunawardana, J., Sabdia, M. B., Szczepanowski, M., Richter, J., Klapper, W. & Louissaint, A. & 18 others, Ludwig, C., Bultmann, S., Leonhardt, H., Eustermann, S., Hopfner, K. P., Hiddemann, W., von Bergwelt-Baildon, M., Steidl, C., Kridel, R., Tobin, J. W. D., Gandhi, M. K., Weinstock, D. M., Schmidt-Supprian, M., Sárosi, M. B., Rudelius, M., Passerini, V., Mautner, J. & Weigert, O., 5 May 2020, In: Cell Reports. 31, 5, 107522.

Research output: Contribution to journal › Article › peer-review

Open Access

57 Scopus citations

C-Rel gain in B cells drives germinal center reactions and autoantibody production

Kober-Hasslacher, M., Oh-Strauß, H., Kumar, D., Soberon, V., Diehl, C., Lech, M., Engleitner, T., Katab, E., Fernández-Sáiz, V., Piontek, G., Li, H., Menze, B., Ziegenhain, C., Enard, W., Rad, R., Böttcher, J. P., Anders, H. J., Rudelius, M. & Schmidt-Supprian, M., 1 Jun 2020, In: Journal of Clinical Investigation. 130, 6, p. 3270-3286 17 p.

Research output: Contribution to journal › Article › peer-review

Open Access

11 Scopus citations

Renal proximal tubular NEMO plays a critical role in ischemic acute kidney injury

Han, S. J., Williams, R. M., Kim, M., Heller, D. A., D'Agati, V., Schmidt-Supprian, M. & Thomas Lee, H., 2 Oct 2020, In: JCI Insight. 5, 19, 139246.

Research output: Contribution to journal › Article › peer-review

Open Access

13 Scopus citations

Stromal cell protein kinase C-β inhibition enhances chemosensitivity in B cell malignancies and overcomes drug resistance

Park, E., Chen, J., Moore, A., Mangolini, M., Santoro, A., Boyd, J. R., Schjerven, H., Ecker, V., Buchner, M., Williamson, J. C., Lehner, P. J., Gasparoli, L., Williams, O., Bloehdorn, J., Stilgenbauer, S., Leitges, M., Egle, A., Schmidt-Supprian, M., Frietze, S. & Ringshausen, I., 15 Jan 2020, In: Science Translational Medicine. 12, 526, eaax9340.

Research output: Contribution to journal › Article › peer-review

Open Access

21 Scopus citations

2019

Chronic CD30 signaling in B cells results in lymphomagenesis by driving the expansion of plasmablasts and B1 cells

Sperling, S., Fiedler, P., Lechner, M., Pollithy, A., Ehrenberg, S., Schiefer, A. I., Kenner, L., Feuchtinger, A., Kühn, R., Swinerd, G., Schmidt-Supprian, M., Strobl, L. J. & Zimber-Strobl, U., 2019, In: Blood. 133, 24, p. 2597-2609 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

16 Scopus citations

PiggyBac transposon tools for recessive screening identify B-cell lymphoma drivers in mice

Weber, J., de la Rosa, J., Grove, C. S., Schick, M., Rad, L., Baranov, O., Strong, A., Pfaus, A., Friedrich, M. J., Engleitner, T., Lersch, R., Öllinger, R., Grau, M., Menendez, I. G., Martella, M., Kohlhofer, U., Banerjee, R., Turchaninova, M. A., Scherger, A. & Hoffman, G. J. & 21 others, Hess, J., Kuhn, L. B., Ammon, T., Kim, J., Schneider, G., Unger, K., Zimber-Strobl, U., Heikenwälder, M., Schmidt-Supprian, M., Yang, F., Saur, D., Liu, P., Steiger, K., Chudakov, D. M., Lenz, G., Quintanilla-Martinez, L., Keller, U., Vassiliou, G. S., Cadiñanos, J., Bradley, A. & Rad, R., 1 Dec 2019, In: Nature Communications. 10, 1, 1415.

Research output: Contribution to journal › Article › peer-review

Open Access

44 Scopus citations

Single-Cell Transcriptomics Identifies the Adaptation of Scart1⁺ Vγ6⁺ T Cells to Skin Residency as Activated Effector Cells

Tan, L., Sandrock, I., Odak, I., Aizenbud, Y., Wilharm, A., Barros-Martins, J., Tabib, Y., Borchers, A., Amado, T., Gangoda, L., Herold, M. J., Schmidt-Supprian, M., Kisielow, J., Silva-Santos, B., Koenecke, C., Hovav, A. H., Krebs, C., Prinz, I. & Ravens, S., 18 Jun 2019, In: Cell Reports. 27, 12, p. 3657-3671.e4

Research output: Contribution to journal › Article › peer-review

Open Access

79 Scopus citations

T cell receptor expression timing and signal strength in the functional differentiation of invariant natural killer T cells

Dashtsoodol, N., Bortoluzzi, S. & Schmidt-Supprian, M., 2019, In: Frontiers in Immunology. 10, APR, 841.

Research output: Contribution to journal › Review article › peer-review

Open Access

19 Scopus citations

The unsolved puzzle of C-rel in B cell lymphoma

Kober-Hasslacher, M. & Schmidt-Supprian, M., Jul 2019, In: Cancers. 11, 7, 941.

Research output: Contribution to journal › Review article › peer-review

Open Access

11 Scopus citations

2018

Notch2 controls non-autonomous Wnt-signalling in chronic lymphocytic leukaemia

Mangolini, M., Götte, F., Moore, A., Ammon, T., Oelsner, M., Lutzny-Geier, G., Klein-Hitpass, L., Williamson, J. C., Lehner, P. J., Dürig, J., Möllmann, M., Rásó-Barnett, L., Hughes, K., Santoro, A., Méndez-Ferrer, S., Oostendorp, R. A. J., Zimber-Strobl, U., Peschel, C., Hodson, D. J. & Schmidt-Supprian, M. & 1 others, Ringshausen, I., 1 Dec 2018, In: Nature Communications. 9, 1, 3839.

Research output: Contribution to journal › Article › peer-review

Open Access

54 Scopus citations

2017

A20 restrains thymic regulatory T Cell development

Fischer, J. C., Otten, V., Kober, M., Drees, C., Rosenbaum, M., Schmickl, M., Heidegger, S., Beyaert, R., Van Loo, G., Chang Li, X., Peschel, C., Schmidt-Supprian, M., Haas, T., Spoerl, S. & Poeck, H., 1 Oct 2017, In: Journal of Immunology. 199, 7, p. 2356-2365 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

31 Scopus citations

Roquin paralogs differentially regulate functional NKT cell subsets

Drees, C., Vahl, J. C., Bortoluzzi, S., Heger, K. D., Fischer, J. C., Wunderlich, F. T., Peschel, C. & Schmidt-Supprian, M., 1 Apr 2017, In: Journal of Immunology. 198, 7, p. 2747-2759 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

14 Scopus citations

Tissue-specific tumorigenesis: Context matters

Schneider, G., Schmidt-Supprian, M., Rad, R. & Saur, D., 1 Apr 2017, In: Nature Reviews Cancer. 17, 4, p. 239-253 15 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

230 Scopus citations

Trans-presentation of IL-6 by dendritic cells is required for the priming of pathogenic T H 17 cells

Heink, S., Yogev, N., Garbers, C., Herwerth, M., Aly, L., Gasperi, C., Husterer, V., Croxford, A. L., Möller-Hackbarth, K., Bartsch, H. S., Sotlar, K., Krebs, S., Regen, T., Blum, H., Hemmer, B., Misgeld, T., Wunderlich, T. F., Hidalgo, J., Oukka, M. & Rose-John, S. & 3 others, Schmidt-Supprian, M., Waisman, A. & Korn, T., 1 Jan 2017, In: Nature Immunology. 18, 1, p. 74-85 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

317 Scopus citations

2016

Alternative splicing of MALT1 controls signalling and activation of CD4 + T cells

Meininger, I., Griesbach, R. A., Hu, D., Gehring, T., Seeholzer, T., Bertossi, A., Kranich, J., Oeckinghaus, A., Eitelhuber, A. C., Greczmiel, U., Gewies, A., Schmidt-Supprian, M., Ruland, J., Brocker, T., Heissmeyer, V., Heyd, F. & Krappmann, D., 12 Apr 2016, In: Nature Communications. 7, 11292.

Research output: Contribution to journal › Article › peer-review

Open Access

91 Scopus citations

Canonical NF-κB signaling is uniquely required for the long-term persistence of functional mature B cells

Derudder, E., Herzog, S., Labi, V., Yasuda, T., Köchert, K., Janz, M., Villunger, A., Schmidt-Supprian, M. & Rajewsky, K., 3 May 2016, In: Proceedings of the National Academy of Sciences of the United States of America. 113, 18, p. 5065-5070 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

18 Scopus citations

K⁺ Efflux-Independent NLRP3 Inflammasome Activation by Small Molecules Targeting Mitochondria

Groß, C. J., Mishra, R., Schneider, K. S., Médard, G., Wettmarshausen, J., Dittlein, D. C., Shi, H., Gorka, O., Koenig, P. A., Fromm, S., Magnani, G., Ćiković, T., Hartjes, L., Smollich, J., Robertson, A. A. B., Cooper, M. A., Schmidt-Supprian, M., Schuster, M., Schroder, K. & Broz, P. & 7 others, Traidl-Hoffmann, C., Beutler, B., Kuster, B., Ruland, J., Schneider, S., Perocchi, F. & Groß, O., 18 Oct 2016, In: Immunity. 45, 4, p. 761-773 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

400 Scopus citations

2015

An Oncogenic Role for Alternative NF-κB Signaling in DLBCL Revealed upon Deregulated BCL6 Expression

Zhang, B., Calado, D. P., Wang, Z., Fröhler, S., Köchert, K., Qian, Y., Koralov, S. B., Schmidt-Supprian, M., Sasaki, Y., Unitt, C., Rodig, S., Chen, W., Dalla-Favera, R., Alt, F. W., Pasqualucci, L. & Rajewsky, K., 2015, In: Cell Reports. 11, 5, p. 715-726 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

71 Scopus citations

A novel Cre recombinase reporter mouse strain facilitates selective and efficient infection of primary immune cells with adenoviral vectors

Heger, K., Kober, M., Rieß, D., Drees, C., de Vries, I., Bertossi, A., Roers, A., Sixt, M. & Schmidt-Supprian, M., 1 Jun 2015, In: European Journal of Immunology. 45, 6, p. 1614-1620 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

11 Scopus citations

Brain endothelial TAK1 and NEMO safeguard the neurovascular unit

Ridder, D. A., Wenzel, J., Müller, K., Töllner, K., Tong, X. K., Assmann, J. C., Stroobants, S., Weber, T., Niturad, C., Fischer, L., Lembrich, B., Wolburg, H., Grand'Maison, M., Papadopoulos, P., Korpos, E., Truchetet, F., Rades, D., Sorokin, L. M., Schmidt-Supprian, M. & Bedell, B. J. & 6 others, Pasparakis, M., Balschun, D., D'Hooge, R., Löscher, W., Hame, E. & Schwaninger, M., 21 Sep 2015, In: Journal of Experimental Medicine. 212, 10, p. 1529-1549 21 p.

Research output: Contribution to journal › Article › peer-review

Open Access

62 Scopus citations

Dicer is indispensable for the development of murine mast cells: To the editor

Förster, A., Blissenbach, B., Machova, A., Leja, S., Rabenhorst, A., Wilmschen, S., Heger, K., Schmidt-Supprian, M., Roers, A., Hartmann, K. & Papadopoulou, N., 1 Apr 2015, In: Journal of Allergy and Clinical Immunology. 135, 4, p. 1077-1080.e4

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Machine learning-based classification of diffuse large B-cell lymphoma patients by their protein expression profiles

Deeb, S. J., Tyanova, S., Hummel, M., Schmidt-Supprian, M., Cox, J. & Mann, M., Nov 2015, In: Molecular and Cellular Proteomics. 14, 11, p. 2947-2960 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

72 Scopus citations

RC3H1 post-transcriptionally regulates A20 mRNA and modulates the activity of the IKK/NF-κ B pathway

Murakawa, Y., Hinz, M., Mothes, J., Schuetz, A., Uhl, M., Wyler, E., Yasuda, T., Mastrobuoni, G., Friedel, C. C., Dölken, L., Kempa, S., Schmidt-Supprian, M., Blüthgen, N., Backofen, R., Heinemann, U., Wolf, J., Scheidereit, C. & Landthaler, M., 14 Jul 2015, In: Nature Communications. 6, 7367.

Research output: Contribution to journal › Article › peer-review

Open Access

94 Scopus citations

TCR signals fuel T_reg cells

Drees, C., Christoph Vahl, J. & Schmidt-Supprian, M., 2015, In: Oncotarget. 6, 26, p. 21773-21774 2 p.

Research output: Contribution to journal › Editorial

Open Access

γ-secretase directly sheds the survival receptor BCMA from plasma cells

Laurent, S. A., Hoffmann, F. S., Kuhn, P. H., Cheng, Q., Chu, Y., Schmidt-Supprian, M., Hauck, S. M., Schuh, E., Krumbholz, M., Rübsamen, H., Wanngren, J., Khademi, M., Olsson, T., Alexander, T., Hiepe, F., Pfister, H. W., Weber, F., Jenne, D., Wekerle, H. & Hohlfeld, R. & 2 others, Lichtenthaler, S. F. & Meinl, E., 11 Jun 2015, In: Nature Communications. 6, 7333.

Research output: Contribution to journal › Article › peer-review

Open Access

302 Scopus citations

2014

Continuous T Cell Receptor Signals Maintain a Functional Regulatory T Cell Pool

Vahl, J. C., Drees, C., Heger, K., Heink, S., Fischer, J. C., Nedjic, J., Ohkura, N., Morikawa, H., Poeck, H., Schallenberg, S., Rieß, D., Hein, M. Y., Buch, T., Polic, B., Schönle, A., Zeiser, R., Schmitt-Gräff, A., Kretschmer, K., Klein, L. & Korn, T. & 2 others, Sakaguchi, S. & Schmidt-Supprian, M., 20 Nov 2014, In: Immunity. 41, 5, p. 722-736 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

255 Scopus citations

Distinct Roles for JNK and IKK Activation in Agouti-Related Peptide Neurons in the Development of Obesity and Insulin Resistance

Tsaousidou, E., Paeger, L., Belgardt, B. F., Pal, M., Wunderlich, C. M., Brönneke, H., Collienne, U., Hampel, B., Wunderlich, F. T., Schmidt-Supprian, M., Kloppenburg, P. & Brüning, J. C., 20 Nov 2014, In: Cell Reports. 9, 4, p. 1495-1506 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

94 Scopus citations

Associate Professorship of Experimental Hematology

Research output

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