Versatile flexible graphene multielectrode arrays

Dmitry Kireev; Silke Seyock; Mathis Ernst; Vanessa Maybeck; Bernhard Wolfrum; Andreas Offenhäusser

doi:10.3390/bios7010001

Versatile flexible graphene multielectrode arrays

Dmitry Kireev, Silke Seyock, Mathis Ernst, Vanessa Maybeck, Bernhard Wolfrum, Andreas Offenhäusser

Professur für Neuroelektronik

Forschungszentrum Jülich (FZJ)

Publikation: Beitrag in Fachzeitschrift › Artikel › Begutachtung

31 Zitate (Scopus)

Abstract

Graphene is a promising material possessing features relevant to bioelectronics applications. Graphene microelectrodes (GMEAs), which are fabricated in a dense array on a flexible polyimide substrate, were investigated in this work for their performance via electrical impedance spectroscopy. Biocompatibility and suitability of the GMEAs for extracellular recordings were tested by measuring electrical activities from acute heart tissue and cardiac muscle cells. The recordings show encouraging signal-to-noise ratios of 65 ± 15 for heart tissue recordings and 20 ± 10 for HL-1 cells. Considering the low noise and excellent robustness of the devices, the sensor arrays are suitable for diverse and biologically relevant applications.

Originalsprache	Englisch
Aufsatznummer	1
Fachzeitschrift	Biosensors
Jahrgang	7
Ausgabenummer	1
DOIs	https://doi.org/10.3390/bios7010001
Publikationsstatus	Veröffentlicht - 23 Dez. 2016

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abstract = "Graphene is a promising material possessing features relevant to bioelectronics applications. Graphene microelectrodes (GMEAs), which are fabricated in a dense array on a flexible polyimide substrate, were investigated in this work for their performance via electrical impedance spectroscopy. Biocompatibility and suitability of the GMEAs for extracellular recordings were tested by measuring electrical activities from acute heart tissue and cardiac muscle cells. The recordings show encouraging signal-to-noise ratios of 65 ± 15 for heart tissue recordings and 20 ± 10 for HL-1 cells. Considering the low noise and excellent robustness of the devices, the sensor arrays are suitable for diverse and biologically relevant applications.",

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AU - Kireev, Dmitry

AU - Seyock, Silke

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AU - Maybeck, Vanessa

AU - Wolfrum, Bernhard

AU - Offenhäusser, Andreas

PY - 2016/12/23

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AB - Graphene is a promising material possessing features relevant to bioelectronics applications. Graphene microelectrodes (GMEAs), which are fabricated in a dense array on a flexible polyimide substrate, were investigated in this work for their performance via electrical impedance spectroscopy. Biocompatibility and suitability of the GMEAs for extracellular recordings were tested by measuring electrical activities from acute heart tissue and cardiac muscle cells. The recordings show encouraging signal-to-noise ratios of 65 ± 15 for heart tissue recordings and 20 ± 10 for HL-1 cells. Considering the low noise and excellent robustness of the devices, the sensor arrays are suitable for diverse and biologically relevant applications.

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KW - Graphene electrodes

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Versatile flexible graphene multielectrode arrays

Abstract

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