Transmission of hepatitis C virus to children and husbands by women infected with contaminated anti-D immunoglobulin

H. Meisel; A. Reip; B. Faltus; D. H. Krüger; H. Porst; M. Wiese; M. Lu; M. Roggendorf

doi:10.1016/S0140-6736(95)91992-9

Transmission of hepatitis C virus to children and husbands by women infected with contaminated anti-D immunoglobulin

H. Meisel, A. Reip, B. Faltus, D. H. Krüger, H. Porst, M. Wiese, M. Lu, M. Roggendorf

Publikation: Beitrag in Fachzeitschrift › Artikel › Begutachtung

134 Zitate (Scopus)

Abstract

In 1978-79 a single-source outbreak of hepatitis C occurred in 2533 women who had received virus- contaminated anti-D immunoglobulin. Children and husbands of 74 women with self-limited, and of 86 women with chronic, hepatitis C were followed up for over 10-15 years. In 3 of 231 investigated children (1·3%) serological evidence for HCV infection was found. However, none of the children developed an apparent or chronic hepatitis. Serum samples of the 94 husbands investigated showed no HCV antibodies or HCV RNA. We consider the risk of intrauterine or perinatal transmission of HCV, as well as that of transmission through close family contacts, to be low. No evidence was found for sexual transmission from women to men.

Originalsprache	Englisch
Seiten (von - bis)	1209-1211
Seitenumfang	3
Fachzeitschrift	The Lancet
Jahrgang	345
Ausgabenummer	8959
DOIs	https://doi.org/10.1016/S0140-6736(95)91992-9
Publikationsstatus	Veröffentlicht - 13 Mai 1995
Extern publiziert	Ja

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abstract = "In 1978-79 a single-source outbreak of hepatitis C occurred in 2533 women who had received virus- contaminated anti-D immunoglobulin. Children and husbands of 74 women with self-limited, and of 86 women with chronic, hepatitis C were followed up for over 10-15 years. In 3 of 231 investigated children (1·3%) serological evidence for HCV infection was found. However, none of the children developed an apparent or chronic hepatitis. Serum samples of the 94 husbands investigated showed no HCV antibodies or HCV RNA. We consider the risk of intrauterine or perinatal transmission of HCV, as well as that of transmission through close family contacts, to be low. No evidence was found for sexual transmission from women to men.",

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T1 - Transmission of hepatitis C virus to children and husbands by women infected with contaminated anti-D immunoglobulin

AU - Meisel, H.

AU - Reip, A.

AU - Faltus, B.

AU - Krüger, D. H.

AU - Porst, H.

AU - Wiese, M.

AU - Lu, M.

AU - Roggendorf, M.

PY - 1995/5/13

Y1 - 1995/5/13

N2 - In 1978-79 a single-source outbreak of hepatitis C occurred in 2533 women who had received virus- contaminated anti-D immunoglobulin. Children and husbands of 74 women with self-limited, and of 86 women with chronic, hepatitis C were followed up for over 10-15 years. In 3 of 231 investigated children (1·3%) serological evidence for HCV infection was found. However, none of the children developed an apparent or chronic hepatitis. Serum samples of the 94 husbands investigated showed no HCV antibodies or HCV RNA. We consider the risk of intrauterine or perinatal transmission of HCV, as well as that of transmission through close family contacts, to be low. No evidence was found for sexual transmission from women to men.

AB - In 1978-79 a single-source outbreak of hepatitis C occurred in 2533 women who had received virus- contaminated anti-D immunoglobulin. Children and husbands of 74 women with self-limited, and of 86 women with chronic, hepatitis C were followed up for over 10-15 years. In 3 of 231 investigated children (1·3%) serological evidence for HCV infection was found. However, none of the children developed an apparent or chronic hepatitis. Serum samples of the 94 husbands investigated showed no HCV antibodies or HCV RNA. We consider the risk of intrauterine or perinatal transmission of HCV, as well as that of transmission through close family contacts, to be low. No evidence was found for sexual transmission from women to men.

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Transmission of hepatitis C virus to children and husbands by women infected with contaminated anti-D immunoglobulin

Abstract

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