TY - JOUR
T1 - Trans-ethnic association study of blood pressure determinants in over 750,000 individuals
AU - Understanding Society Scientific Group
AU - International Consortium for Blood Pressure
AU - Blood Pressure-International Consortium of Exome Chip Studies
AU - Million Veteran Program
AU - Giri, Ayush
AU - Hellwege, Jacklyn N.
AU - Keaton, Jacob M.
AU - Park, Jihwan
AU - Qiu, Chengxiang
AU - Warren, Helen R.
AU - Torstenson, Eric S.
AU - Kovesdy, Csaba P.
AU - Sun, Yan V.
AU - Wilson, Otis D.
AU - Robinson-Cohen, Cassianne
AU - Roumie, Christianne L.
AU - Chung, Cecilia P.
AU - Birdwell, Kelly A.
AU - Damrauer, Scott M.
AU - DuVall, Scott L.
AU - Klarin, Derek
AU - Cho, Kelly
AU - Wang, Yu
AU - Evangelou, Evangelos
AU - Cabrera, Claudia P.
AU - Wain, Louise V.
AU - Shrestha, Rojesh
AU - Mautz, Brian S.
AU - Akwo, Elvis A.
AU - Sargurupremraj, Muralidharan
AU - Debette, Stéphanie
AU - Boehnke, Michael
AU - Scott, Laura J.
AU - Luan, Jian’an
AU - Zhao, Jing Hua
AU - Willems, Sara M.
AU - Thériault, Sébastien
AU - Shah, Nabi
AU - Oldmeadow, Christopher
AU - Almgren, Peter
AU - Li-Gao, Ruifang
AU - Verweij, Niek
AU - Boutin, Thibaud S.
AU - Mangino, Massimo
AU - Ntalla, Ioanna
AU - Feofanova, Elena
AU - Surendran, Praveen
AU - Cook, James P.
AU - Karthikeyan, Savita
AU - Lahrouchi, Najim
AU - Liu, Chunyu
AU - Sepúlveda, Nuno
AU - Richardson, Tom G.
AU - Zeggini, Eleftheria
N1 - Publisher Copyright:
© 2018, The Author(s), under exclusive licence to Springer Nature America, Inc.
PY - 2019/1/1
Y1 - 2019/1/1
N2 - In this trans-ethnic multi-omic study, we reinterpret the genetic architecture of blood pressure to identify genes, tissues, phenomes and medication contexts of blood pressure homeostasis. We discovered 208 novel common blood pressure SNPs and 53 rare variants in genome-wide association studies of systolic, diastolic and pulse pressure in up to 776,078 participants from the Million Veteran Program (MVP) and collaborating studies, with analysis of the blood pressure clinical phenome in MVP. Our transcriptome-wide association study detected 4,043 blood pressure associations with genetically predicted gene expression of 840 genes in 45 tissues, and mouse renal single-cell RNA sequencing identified upregulated blood pressure genes in kidney tubule cells.
AB - In this trans-ethnic multi-omic study, we reinterpret the genetic architecture of blood pressure to identify genes, tissues, phenomes and medication contexts of blood pressure homeostasis. We discovered 208 novel common blood pressure SNPs and 53 rare variants in genome-wide association studies of systolic, diastolic and pulse pressure in up to 776,078 participants from the Million Veteran Program (MVP) and collaborating studies, with analysis of the blood pressure clinical phenome in MVP. Our transcriptome-wide association study detected 4,043 blood pressure associations with genetically predicted gene expression of 840 genes in 45 tissues, and mouse renal single-cell RNA sequencing identified upregulated blood pressure genes in kidney tubule cells.
UR - http://www.scopus.com/inward/record.url?scp=85058906993&partnerID=8YFLogxK
U2 - 10.1038/s41588-018-0303-9
DO - 10.1038/s41588-018-0303-9
M3 - Article
C2 - 30578418
AN - SCOPUS:85058906993
SN - 1061-4036
VL - 51
SP - 51
EP - 62
JO - Nature Genetics
JF - Nature Genetics
IS - 1
ER -