TY - JOUR
T1 - Toward the Understanding of Immunosuppression
AU - Kessler, Horst
AU - Mierke, Dale F.
AU - Donald, David
AU - Furber, Mark
PY - 1991/8
Y1 - 1991/8
N2 - Cyclosporin, FK506, and rapamycin exhibit astounding immunosuppressive effects. The first of these is a cyclic undecapeptide, the second a peptide macrolide. In the cytosol they bind to proteins that exhibit rotamase activity. Presumably, therefore, these immunosuppressives inhibit the ubiquitous rotamases. Much information has been obtained recently on the structures of FK506 and its complex with the FK506 binding protein, and the mechanism of action of these compounds is beginning to emerge. (Figure Presented.)
AB - Cyclosporin, FK506, and rapamycin exhibit astounding immunosuppressive effects. The first of these is a cyclic undecapeptide, the second a peptide macrolide. In the cytosol they bind to proteins that exhibit rotamase activity. Presumably, therefore, these immunosuppressives inhibit the ubiquitous rotamases. Much information has been obtained recently on the structures of FK506 and its complex with the FK506 binding protein, and the mechanism of action of these compounds is beginning to emerge. (Figure Presented.)
UR - http://www.scopus.com/inward/record.url?scp=0025913670&partnerID=8YFLogxK
U2 - 10.1002/anie.199109541
DO - 10.1002/anie.199109541
M3 - Article
AN - SCOPUS:0025913670
SN - 0570-0833
VL - 30
SP - 954
EP - 955
JO - Angewandte Chemie International Edition in English
JF - Angewandte Chemie International Edition in English
IS - 8
ER -