TY - GEN
T1 - Therapeutic drug monitoring for a personalized antibiotherapy
AU - Bruch, R.
AU - Chatelle, C.
AU - Kling, A.
AU - Dincer, C.
AU - Wirth, S.
AU - Schumann, S.
AU - Weber, W.
AU - Urban, G.
N1 - Publisher Copyright:
© 17CBMS-0001.
PY - 2020
Y1 - 2020
N2 - For the therapeutic drug monitoring (TDM) of β-lactam antibiotics at the patient's bedside, a novel approach of an electrochemical, microfluidic platform is presented. Herein, a highly sensitive, low-cost and versatile biosensor is combined with an enzyme linked assay (ELA), using the penicillin binding protein 3 (PBP-3) for a fast and facile detection of ß-lactams (less than 1 hour) from very low sample volumes (580 nl). The system applicability is successfully demonstrated by monitoring the antibiotic blood concentration of patients, receiving antibiotherapy (cefuroxime and cefazolin), while undergoing surgery.
AB - For the therapeutic drug monitoring (TDM) of β-lactam antibiotics at the patient's bedside, a novel approach of an electrochemical, microfluidic platform is presented. Herein, a highly sensitive, low-cost and versatile biosensor is combined with an enzyme linked assay (ELA), using the penicillin binding protein 3 (PBP-3) for a fast and facile detection of ß-lactams (less than 1 hour) from very low sample volumes (580 nl). The system applicability is successfully demonstrated by monitoring the antibiotic blood concentration of patients, receiving antibiotherapy (cefuroxime and cefazolin), while undergoing surgery.
KW - Electrochemical Biosensor
KW - Microfluidic
KW - Personalized Antibiotherapy
KW - Point-Of-Care
KW - ß-Lactams
UR - https://www.scopus.com/pages/publications/85079596904
M3 - Conference contribution
AN - SCOPUS:85079596904
T3 - 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017
SP - 1189
EP - 1190
BT - 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017
PB - Chemical and Biological Microsystems Society
T2 - 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017
Y2 - 22 October 2017 through 26 October 2017
ER -