TY - JOUR
T1 - The ventral fiber pathway for pantomime of object use
AU - Vry, Magnus Sebastian
AU - Tritschler, Linda C.
AU - Hamzei, Farsin
AU - Rijntjes, Michel
AU - Kaller, Christoph P.
AU - Hoeren, Markus
AU - Umarova, Roza
AU - Glauche, Volkmar
AU - Hermsdoerfer, Joachim
AU - Goldenberg, Georg
AU - Hennig, Juergen
AU - Weiller, Cornelius
N1 - Publisher Copyright:
© 2014 Elsevier Inc.
PY - 2015/2/1
Y1 - 2015/2/1
N2 - The current concept of a dual loop system of brain organization predicts a domain-general dual-pathway architecture involving dorsal and ventral fiber connections. We investigated if a similar dichotomy of brain network organization applies for pantomime (P) and imitation of meaningless gestures (I). Impairments of these tasks occur after left hemispheric brain lesions causing apraxia. Isolated impairments and double-dissociations point towards an anatomical segregation. Frontal and parietal areas seem to contribute differently. A special role of the inferior frontal gyrus and underlying fiber pathways was suggested recently. Using a combined fMRI/DTI-approach, we compared the fiber pathway architecture of left hemispheric frontal, temporal and parietal network components of pantomime and imitation. Thereby, we separated object effects from pantomime-specific effects. P and I both engage a fronto-temporo-parietal network of cortical areas interconnected by a dorsal fiber system (superior longitudinal fascicle) for direct sensory-motor interactions. The pantomime-specific effect additionally involved the triangular part of the inferior frontal gyrus, the middle temporal gyrus, the inferior parietal cortex and the intraparietal sulcus, interconnected by ventral fibers of the extreme capsule, likely related to higher-order conceptual and semantic operations. We discuss this finding in the context of the dual loop model and recent anatomical concepts.
AB - The current concept of a dual loop system of brain organization predicts a domain-general dual-pathway architecture involving dorsal and ventral fiber connections. We investigated if a similar dichotomy of brain network organization applies for pantomime (P) and imitation of meaningless gestures (I). Impairments of these tasks occur after left hemispheric brain lesions causing apraxia. Isolated impairments and double-dissociations point towards an anatomical segregation. Frontal and parietal areas seem to contribute differently. A special role of the inferior frontal gyrus and underlying fiber pathways was suggested recently. Using a combined fMRI/DTI-approach, we compared the fiber pathway architecture of left hemispheric frontal, temporal and parietal network components of pantomime and imitation. Thereby, we separated object effects from pantomime-specific effects. P and I both engage a fronto-temporo-parietal network of cortical areas interconnected by a dorsal fiber system (superior longitudinal fascicle) for direct sensory-motor interactions. The pantomime-specific effect additionally involved the triangular part of the inferior frontal gyrus, the middle temporal gyrus, the inferior parietal cortex and the intraparietal sulcus, interconnected by ventral fibers of the extreme capsule, likely related to higher-order conceptual and semantic operations. We discuss this finding in the context of the dual loop model and recent anatomical concepts.
KW - DTI
KW - Dual loop model
KW - FMRI
KW - Fiber network
KW - Imitation
KW - Pantomime
UR - http://www.scopus.com/inward/record.url?scp=84920138387&partnerID=8YFLogxK
U2 - 10.1016/j.neuroimage.2014.11.002
DO - 10.1016/j.neuroimage.2014.11.002
M3 - Article
C2 - 25462791
AN - SCOPUS:84920138387
SN - 1053-8119
VL - 106
SP - 252
EP - 263
JO - NeuroImage
JF - NeuroImage
ER -